Recombinant Cricetulus Griseus P4HB Protein (20-509 aa), His-tagged

Cat.No. : P4HB-2042C
Product Overview : Recombinant Cricetulus Griseus (Chinese hamster) (Cricetulus barabensis griseus) P4HB Protein (20-509 aa) is produced by E. coli expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Signal Transduction. Protein Description: Full Length of Mature Protein.
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Description : This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration.
Source : E. coli
Species : Cricetulus Griseus
Tag : His
Form : Tris-based buffer,50% glycerol
Molecular Mass : 59.0 kDa
Protein length : 20-509 aa
AA Sequence : DAPEEEDNVLVLKKSNFAEALAAHN YLLVEFYAPWCGHCKALAPEYAKAA AKLKAEGSEIRLAKVDATEESDLAQ QYGVRGYPTIKFFKNGDTASPKEYT AGREADDIVNWLKKRTGPAATTLSD TAAAETLIDSSEVAVIGFFKDVESD SAKQFLLAAEAVDDIPFGITSNSGV FSKYQLDKDGVVLFKKFDEGRNNFE GEVTKEKLLDFIKHNQLPLVIEFTE QTAPKIFGGEIKTHILLFLPKSVSD YDGKLGNFKKAAEGFKGKILFIFID SDHTDNQRILEFFGLKKEECPAVRL ITLEEEMTKYKPESDELTAEKITEF CHRFLEGKIKPHLMSQELPEDWDKQ PVKVLVGKNFEEVAFDEKKNVFVEF YAPWCGHCKQLAPIWDKLGETYKDH ENIIIAKMDSTANEVEAVKVHSFPT LKFFPATADRTVIDYNGERTLDGFK KFLESGGQDGAGDDDDVDLEEALEP DMEEDDDQKAVKDEL
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with reconstitution instruction is sent along with the products.
SDS-PAGE: (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Gene Name : P4hb prolyl 4-hydroxylase subunit beta [ Cricetulus griseus (Chinese hamster) ]
Official Symbol : P4HB
Synonyms : PDI; p58; PDIA1;
Gene ID : 100689433
UniProt ID : Q8R4U2

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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