| Description : |
This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration. |
| Source : |
Insect cell |
| Species : |
Mouse |
| Tag : |
His |
| Form : |
Liquid |
| Molecular Mass : |
56.1 kDa |
| Protein length : |
20-509 |
| AA Sequence : |
DALEEEDNVLVLKKSNFEEALAAHK YLLVEFYAPWCGHCKALAPEYAKAA AKLKAEGSEIRLAKVDATEESDLAQ QYGVRGYPTIKFFKNGDTASPKEYT AGREADDIVNWLKKRTGPAATTLSD TAAAESLVDSSEVTVIGFFKDVESD SAKQFLLAAEAIDDIPFGITSNSGV FSKYQLDKDGVVLFKKFDEGRNNFE GEITKEKLLDFIKHNQLPLVIEFTE QTAPKIFGGEIKTHILLFLPKSVSD YDGKLSSFKRAAEGFKGKILFIFID SDHTDNQRILEFFGLKKEECPAVRL ITLEEEMTKYKPESDELTAEKITEF CHRFLEGKIKPHLMSQEVPEDWDKQ PVKVLVGANFEEVAFDEKKNVFVEF YAPWCGHCKQLAPIWDKLGETYKDH ENIIIAKMDSTANEVEAVKVHSFPT LKFFPASADRTVIDYNGERTLDGFK KFLESGGQDGAGDDEDLDLEEALEP DMEEDDDQKAVKDELLEHHHHHH |
| Endotoxin : |
< 1.0 EU/μg of protein (determined by LAL method) |
| Purity : |
> 95 % by SDS-PAGE |
| Stability : |
Shelf life: one year from despatch. |
| Storage : |
Store undiluted at 2-8 centigrade for one week or (in aliquots) at -20 to -80 centigrade for longer. Avoid repeated freezing and thawing. |
| Concentration : |
0.5 mg/mL (determined by absorbance at 280nm) |
| Storage Buffer : |
Phosphate Buffered Saline (pH 7.4) containing 10 % glycerol. |
