Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Mouse P4hb Protein, His-tagged

Cat.No. : P4hb-7294M
Product Overview : Recombinant Mouse P4hb protein with a His tag was expressed in insect cells.
  • Specification
  • Gene Information
  • Related Products
Description : This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration.
Source : Insect cell
Species : Mouse
Tag : His
Form : Liquid
Molecular Mass : 56.1 kDa
Protein length : 20-509
AA Sequence : DALEEEDNVLVLKKSNFEEALAAHK YLLVEFYAPWCGHCKALAPEYAKAA AKLKAEGSEIRLAKVDATEESDLAQ QYGVRGYPTIKFFKNGDTASPKEYT AGREADDIVNWLKKRTGPAATTLSD TAAAESLVDSSEVTVIGFFKDVESD SAKQFLLAAEAIDDIPFGITSNSGV FSKYQLDKDGVVLFKKFDEGRNNFE GEITKEKLLDFIKHNQLPLVIEFTE QTAPKIFGGEIKTHILLFLPKSVSD YDGKLSSFKRAAEGFKGKILFIFID SDHTDNQRILEFFGLKKEECPAVRL ITLEEEMTKYKPESDELTAEKITEF CHRFLEGKIKPHLMSQEVPEDWDKQ PVKVLVGANFEEVAFDEKKNVFVEF YAPWCGHCKQLAPIWDKLGETYKDH ENIIIAKMDSTANEVEAVKVHSFPT LKFFPASADRTVIDYNGERTLDGFK KFLESGGQDGAGDDEDLDLEEALEP DMEEDDDQKAVKDELLEHHHHHH
Endotoxin : < 1.0 EU/μg of protein (determined by LAL method)
Purity : > 95 % by SDS-PAGE
Stability : Shelf life: one year from despatch.
Storage : Store undiluted at 2-8 centigrade for one week or (in aliquots) at -20 to -80 centigrade for longer. Avoid repeated freezing and thawing.
Concentration : 0.5 mg/mL (determined by absorbance at 280nm)
Storage Buffer : Phosphate Buffered Saline (pH 7.4) containing 10 % glycerol.
Gene Name : P4hb prolyl 4-hydroxylase, beta polypeptide [ Mus musculus (house mouse) ]
Official Symbol : P4hb
Synonyms : P4hb; prolyl 4-hydroxylase, beta polypeptide; P; Pd; ERp; PDI; Thb; Thbp; ERp59; Pdia1; protein disulfide-isomerase; ER protein 59; cellular thyroid hormone-binding protein; endoplasmic reticulum resident protein 59; p55; prolyl 4-hydroxylase subunit beta; EC 5.3.4.1
Gene ID : 18453
mRNA Refseq : NM_011032
Protein Refseq : NP_035162
UniProt ID : P09103

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

0

Inquiry Basket

cartIcon
logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends