Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953


  • Official Full Name

    protein arginine methyltransferase 5

  • Overview

    Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. Methylates RPS10.
  • Synonyms

    PRMT5; protein arginine methyltransferase 5; JBP1; SKB1; IBP72; SKB1Hs; HRMT1L5; protein arginine N-methyltransferase 5; SKB1 homolog; jak-binding protein 1; 72 kDa ICln-binding protein; HMT1 hnRNP methyltransferase-like 5; shk1 kinase-binding protein 1 homolog; histone-arginine N-methyltransferase PRMT5;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • Free Style 293-F Cell
  • HEK293
  • HEK293T
  • Human Cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Flag
  • Flag|His
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PRMT5-2321H Recombinant Human PRMT5 protein, His&FLAG-tagged HEK293 His/Flag Ala2-Leu637
Human PRMT5-1969H Recombinant Human PRMT5, GST-tagged E.coli GST 283-637aa
Human PRMT5-6962H Recombinant Human PRMT5, GST-tagged Sf9 Insect Cell GST Full length
Human PRMT5-1618H Recombinant Human Protein Arginine Methyltransferase 5, GST-tagged Sf9 Insect Cell GST
Human PRMT5-177H Recombinant Human PRMT5 Protein, Flag-tagged Insect Cell Flag 2-637
Human PRMT5&MEP50-315H Recombinant Human PRMT5&MEP50 protein, Flag/His-tagged Insect Cell Flag/His
Human PRMT5-452H Recombinant Human Protein Arginine Methyltransferase 5 Free Style 293-F Cell N/A
Human PRMT5-178H Recombinant Human PRMT5/MEP50 complex Protein, Flag/His-tagged Insect Cell Flag/His PRMT5 2-637(C-term.), MEP50 2-342 (C-term.)
Human PRMT5-32H Recombinant Human PRMT5/WDR77 protein, FLAG/His-tagged HEK293 Flag/His
Human PRMT5-2577HCL Recombinant Human PRMT5 cell lysate Human Cell N/A
Human PRMT5-3004H Recombinant Human PRMT5 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PRMT5-3632H Recombinant Human PRMT5 protein, GST-tagged E.coli GST 1-280 aa
Human PRMT5-301624H Recombinant Human PRMT5 protein, GST-tagged E.coli GST Tyr283-Leu637
Human PRMT5-4447H Recombinant Human PRMT5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PRMT5-1771H Recombinant Human PRMT5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PRMT5-3528H Recombinant Human PRMT5 protein, His-tagged E.coli His 283-637 aa
Human PRMT5-688HFL Recombinant Full Length Human PRMT5 Protein, C-Flag-tagged Mammalian cells Flag
Human PRMT5-1771H-B Recombinant Human PRMT5 Protein Pre-coupled Magnetic Beads HEK293
Mouse PRMT5-13419M Recombinant Mouse PRMT5 Protein Mammalian Cell His
Mouse PRMT5-7125M-B Recombinant Mouse PRMT5 Protein Pre-coupled Magnetic Beads HEK293
Mouse PRMT5-7125M Recombinant Mouse PRMT5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Prmt5-5133M Recombinant Mouse Prmt5 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rhesus Macaque PRMT5-3614R Recombinant Rhesus monkey PRMT5 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PRMT5-3432R Recombinant Rhesus Macaque PRMT5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PRMT5-3432R-B Recombinant Rhesus Macaque PRMT5 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PRMT5-1659Z Recombinant Zebrafish PRMT5 Mammalian Cell His
Kit-1858 PRMT5 Chemiluminescent Assay Kit N/A
Kit-1859 PRMT5 Homogeneous Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PRMT5 Related Articles
  • PRMT5 Related Research Area

PRMT5 involved in several pathways and played different roles in them. We selected most pathways PRMT5 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, E2F transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRMT5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chromatin modifying enzymesSMARCB1;KAT6B;KANSL2;HIST2H3C;PRMT7;VPS72;ARID4A;BRMS1;KDM7AB
E2F transcription factor networkTRIM28;DHFR;RYBP;HIC1;RBBP8;UXT;HBP1;CES3;E2F4
Metabolism of non-coding RNADDX20;SNUPN;WDR77;PEAK1;PRMT5;CLNS1A
Signaling events mediated by HDAC Class IGATA2;FKBP3;SIRT2;PRMT5;SIRT4;NR2C1;SIRT5;SIRT7;WDR77

PRMT5 has several biochemical functions, for example, core promoter sequence-specific DNA binding, histone-arginine N-methyltransferase activity, methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRMT5 itself. We selected most functions PRMT5 had, and list some proteins which have the same functions with PRMT5. You can find most of the proteins on our site.

Function Related Protein
core promoter sequence-specific DNA bindingNRF1;PROX1;CREM;SOX4;REST;PDX1;MEOX1;CHD2;ATF4
histone-arginine N-methyltransferase activityPRMT6;PRMT8;PRMT5;PRMT3;CARM1;PRMT2;PRMT7
methyltransferase activityNSUN3;MLL1;C9orf114;METTL22;NSUN6;SETD1B;METTL17;THUMPD2;SETDB1B
protein complex bindingNDUFA8;CRIPT;VAMP2;STRN;YWHAB;KRAS;RNF40;CRHR1;EP300
protein heterodimerization activityTAF9;PML;GRIN2A;TPD52L1;SOX32;NEFH;BOKA;HIST1H2AG;P2RY1
protein-arginine N-methyltransferase activityMETTL21D;DIMT1;PRDM13;FBXO11;TRMT10C;CARM1;FAM86;METTL21A;METTL7B
protein-arginine omega-N symmetric methyltransferase activityPRMT7;PRMT5
ribonucleoprotein complex bindingPRMT7;PES;CKAP5;RNASEL;SECISBP2;PPIH;PRMT5;PIGC;ITCH
transcription corepressor activityBATF3;ZHX3;YWHAB;ZFPM1;ID4;RLIM;E2F7;MXD1;HOMEZB

PRMT5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRMT5 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRMT5.


Uzdensky, A; Demyanenko, S; et al. Expression of proteins involved in epigenetic regulation in human cutaneous melanoma and peritumoral skin. TUMOR BIOLOGY 35:8225-8233(2014).
McLaughlin, N; Wang, FL; et al. In situ histone landscape of nephrogenesis. EPIGENETICS 9:222-235(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there any ongoing clinical trials targeting PRMT5? 05/31/2021

Yes, there are ongoing clinical trials investigating the efficacy of PRMT5 inhibitors in various cancer types.

How does PRMT5 affect cellular differentiation? 12/10/2019

PRMT5 influences cellular differentiation by regulating the expression of genes involved in the process.

Can PRMT5 inhibitors be used in combination therapies? 07/05/2018

Yes, there is interest in exploring combination therapies involving PRMT5 inhibitors with other anticancer agents to enhance treatment efficacy.

How does PRMT5 contribute to epigenetic regulation? 04/26/2016

PRMT5 methylates histone proteins, leading to changes in chromatin structure and gene expression, thus playing a crucial role in epigenetic regulation.

How does PRMT5 influence neurodegenerative diseases? 01/04/2016

PRMT5 has been implicated in neurodegenerative diseases, and understanding its role may provide insights into developing therapies for conditions like Alzheimer's and Parkinson's disease.

Customer Reviews (3)

Write a review

    Great performance in ELISA.


      Its purity and functionality ensure precise and reproducible results, enabling me to achieve my research objectives with confidence.


        The PRMT5 protein demonstrates exceptional quality, making it an ideal candidate to fulfill my experimental requirements.

        Ask a Question for All PRMT5 Products

        Required fields are marked with *

        My Review for All PRMT5 Products

        Required fields are marked with *


        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends