Active Recombinant Human PROM1 Full Length Transmembrane protein(VLPs)

• Cat.No.: PROM1-712H
• Product Overview: Active Recombinant Human PROM1 Full Length Transmembrane protein(VLPs)(O43490-1)(Gly 20 - His 865) is expressed from human 293 cells (HEK293).

Specification

• Source: HEK293
• Species: Human
• Tag: Non
• Form: Supplied as 0.2 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
• Bio-activity: Immobilized Human CD133 Full Length-VLP at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human CD133 Antibody,Mouse IgG1 with a linear range of 0.2-4 ng/mL.
• Protein length: Gly 20 - His 865
• Endotoxin: Less than 1.0 EU per μg by the LAL method.
• Storage: This product is stable after storage at:
  The product MUST be stored at -70°C or lower upon receipt;
  -70°C for 12 months under sterile conditions.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: PROM1 prominin 1 [ Homo sapiens ]
• Official Symbol: PROM1
• Synonyms: PROM1; prominin 1; macular dystrophy, retinal 2 , MCDR2, prominin (mouse) like 1 , PROML1, Stargardt disease 4 (autosomal dominant) , STGD4; prominin-1; AC133; CD133; RP41; hProminin; antigen AC133; prominin-like protein 1; hematopoietic stem cell antigen; MCDR2; STGD4; CORD12; PROML1; MSTP061
• Gene ID: 8842
• mRNA Refseq: NM_001145847
• Protein Refseq: NP_001139319
• MIM: 604365
• UniProt ID: O43490

Reviews

05/01/2021

They can offer detailed characterization data, including purity, stability, and functional assessments, to support researchers' confidence in using the protein in their trials.

10/01/2017

Manufacturers can support researchers in developing assays to measure PROM1 protein levels or activity specific to their clinical trial settings.

12/14/2016

This may involve guidance in selecting appropriate detection methods, providing assay components, or optimizing protocols for optimal performance and sensitivity.

Q&As

Are there specific diseases where PROM1 protein is extensively studied?

Yes, PROM1's role is widely studied in various cancers, including brain, breast, colon, and pancreatic cancers.

What methods are used to study PROM1 protein in clinical settings?

Various laboratory techniques, such as flow cytometry, immunohistochemistry, and molecular biology assays, are employed to study PROM1 expression and function.

Is PROM1 exclusively related to cancer and regenerative medicine?

No, PROM1 is also associated with certain eye disorders and is being researched for potential applications in retinal diseases.

Can PROM1 be a potential target for therapeutic interventions?

Research suggests that it could be a target for treatments aimed at eliminating cancer stem cells and potentially preventing cancer relapse.

Are there any side effects associated with targeting PROM1 in therapies?

The potential impact on normal stem cells and unintended consequences on healthy tissues are areas of concern when targeting PROM1 for therapies.