RELA

  • Official Full Name

    v-rel reticuloendotheliosis viral oncogene homolog A

  • Overview

    Transcription factor p65 is a protein that in humans is encoded by the RELA gene. NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NF-κB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NF-κB. The NF-κB complex is inhibited by IκB (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NF-κB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-κB complex. Activated NF-κB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]
  • Synonyms

    RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian); NFKB3; p65; Nuclear factor NF-kappa-B p65 subunit; MGC131774; transcription factor p65; OTTHUMP00000233473; OTHUMP00000233474; OTTHUMP00000233475; OTTHUMP00000233476; OTTHUMP00000233900; nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65; v-rel avian reticuloendotheliosis; viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (p65));

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Bacillus subtilis
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E. coli
  • E. coli or Yeast
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • N/A
  • Sf21 Insect Cell
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RELA-627TH Recombinant Human RELA, C-Terminal Truncated N/A N/A
Human RELA-30384TH Recombinant Human RELA Wheat Germ N/A
Human RELA-634H Recombinant Human RELA, His-tagged Sf21 Insect Cell His
Human RELA-7009H Recombinant Human RELA protein, GST-tagged E.coli GST
Human RELA-622H Recombinant Human RELA Protein, GST-tagged E.coli GST
Human RELA-30386TH Recombinant Human RELA Wheat Germ N/A
Human RELA-611H Recombinant Human RELA protein, His & T7-tagged E.coli His/T7
Human RELA-2423HCL Recombinant Human RELA 293 Cell Lysate HEK293 N/A
Human RELA-729H Recombinant Human RELA Protien, GST-tagged E. coli GST
Human RELA-333H Recombinant Human NFκB3 (RELA/p65) Protein, Flag-tagged Insect Cells Flag
Human RELA-11HFL Active Recombinant Full Length Human RELA Protein, C-Flag-tagged Mammalian cells Flag
Human RELA-2484H Recombinant Human RELA Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human RELA-1878H Recombinant Human RELA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human RELA-3019H Recombinant Human RELA protein, GST-tagged E.coli GST
Human RELA-6166H Recombinant Human RELA Protein (Met1-Gln220), N-His tagged E.coli N-His
Human RELA-1878H-B Recombinant Human RELA Protein Pre-coupled Magnetic Beads HEK293
Human RELA-6165H Recombinant Human RELA Protein (Pro19-Asp291), C-His tagged E.coli C-His
Mouse Rela-15M Recombinant Mouse Rela protein E.coli N/A
Mouse Rela-612M Recombinant Mouse Rela protein, His & T7-tagged E.coli His/T7
Mouse Rela-5456M Recombinant Mouse Rela Protein, Myc/DDK-tagged HEK293T Myc/DDK
Bacillus subtilis RELA-0549B Recombinant Bacillus subtilis RELA protein, His-tagged E. coli or Yeast His
Zebrafish RELA-248Z Recombinant Zebrafish RELA Mammalian Cell His
Zebrafish rela-2736Z Recombinant Zebrafish rela Protein, His-tagged E.coli N-His
Chicken RELA-6686C Recombinant Chicken RELA Mammalian Cell His
Kit-1652 HEK 293 RELA Nuclear Translocation Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RELA Related Articles
  • RELA Related Research Area
  • RELA Related Signal Pathway

RELA involved in several pathways and played different roles in them. We selected most pathways RELA participated on our site, such as MAPK signaling pathway, Ras signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RELA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayPRKCA;JUND;ATF4B1;PDGFRB;RAC2;TRP53;FGF1A;CACNA1H;RAF1A
Ras signaling pathwayKitl;RRAS;HRAS;MET;RASSF1;CALML3;RRAS2;GNG13;FGF17
cAMP signaling pathwayRYR2;CAMK2A;NFATC1;MAPK10;FSHB;GRIA3;VIPR2;PLD1;ATP1A2
Chemokine signaling pathwayCCL3;Ccl9;CCR7;RLN1;PIK3CD;ARRB2;CCL28;PRKCB;RELA
NF-kappa B signaling pathwayGADD45B;DDX58;PIAS4;UBE2I;CD40LG;CCL4;IKBKG;IKBKB;LBP
HIF- signaling pathwayHIF1A;VHL;PIK3CG;PIK3CB;TEK;SLC2A1;RPS6KB2;TCEB1;STAT3
Sphingolipid signaling pathwayPRKCA;GNAI2;PPP2R3C;OPRD1;RAC3;MAPK10;MAPK1;SMPD1;FYN
PIK-Akt signaling pathwayGNG4;GNG12;FGF20;FLT4;GNG10;LAMC1;IL4R;GNG3;BRCA1
ApoptosisHMGB2A;DSG2;TICAM1;FADD;DAPK1;BADB;PPP3CCA;TP53;BOKA
Osteoclast differentiationLILRB2;MAPK13;LCP2;FCGR3;TGFBR1;IFNG;TGFB2;FCGR4;OSCAR
Toll-like receptor signaling pathwayIFNA7;IFNB;IRF5;TLR4BA;IFNA5;RIPK1L;IL8L2;CRFB2;MAPK8A
NOD-like receptor signaling pathwayTNFAIP3;MAPK11;IKBKG;Ccl12;NFKBIAA;PSTPIP1;HSP90AB1;TAB2;CASPA
RIG-I-like receptor signaling pathwayCXCL10;IFNA13;IFNA8;IL12B;IKBKB;NFKBIAB;IFNA16;MAP3K1;TBKBP1
Cytosolic DNA-sensing pathwayIKBKB;POLR3E;IFNB1;AIM2;IFNA10;RIPK1;OSTN;PYCARD;TMEM173
T cell receptor signaling pathwayPAK3;GSK3B;PAK1;PIK3R1;CDC42;LCK;CD40LG;PPP3CA;NRAS
B cell receptor signaling pathwayIKBKG;PLEKHA2;PTPN6;LIME1;PDK2B;CR2;PIK3CD;NFATC3;GRB2
TNF signaling pathwayBIRC2;MAPK13;CXCL5;RIPK1;CREB3L2;LTA;MLKL;MMP3;NFKB1
Neurotrophin signaling pathwayMAPK7;NTRK1;IRAK2;NTF4;CAMK4;SH2B3;RPS6KA2;KIDINS220;CAMK2B
Prolactin signaling pathwayMAPK8;PIK3CD;PIK3R2;SHC3;SIRPA;SLC2A2;AKT2;FOS;MAPK13
Adipocytokine signaling pathwayIKBKG;ADIPOR1;AKT1;LEPB;PRKCQ;RXRAA;CPT1A;PPARGC1A;PRKAA2
Insulin resistancePPARAB;PRKAG3B;INS2;PIK3CA;PTENA;IL6;TBC1D4;INSRB;GSK3AA
Non-alcoholic fatty liver disease (NAFLD)COX5A;PIK3CA;UQCR11;NDUFS3;INS;NDUFA4L2;DDIT3;PPARA;BAX
Cocaine addictionGNAI1;GRIN2D;PRKACB;GRIN2B;GPSM1;GRIN3A;PDYN;CREB3L4;CDK5R1
Epithelial cell signaling in Helicobacter pylori infectionCDC42;RELA;JAM3;ATP6V1F;ATP6V1B1;CXCL1;MAPK11;TJP1;ATP6V1E2
ShigellosisVCL;ELMO1;IKBKB;IL-8;ROCK1;HCLS1;MAPK3;PFN1;MAPK1
Salmonella infectionMAPK12;RAB7;TJP1;ROCK2;IFNGR1;PFN4;MYH10;IFNG1-2;PKN2
PertussisIRF3;GNAI2;IRAK4;MAPK13;MAPK10;MAPK11;CALM1;NLRP3;C1R
LegionellosisCXCL3;MYD88;NAIP1;ITGB2L;NAIP6;NLRC4;NFKB2;ITGB2;HSPA1A
LeishmaniasisCYBA;HLA-DOA;TGFB2;ITGB1;IFNGR2;HLA-DQA1;NCF1;Itgam&Itgb2;ITGB2
Chagas disease (American trypanosomiasis)FOS;TICAM1;FAS;CFLAR;GNAI3;TLR4;CALR;PIK3R2;IRAK4
ToxoplasmosisHSPA1L;HLA-DRA;IL10RA;PDPK1;LAMC2;MAPK11;BIRC2;CD40LG;XIAP
AmoebiasisARG1;CXCL1;GM-CSF;RAB7;Casp3;C9;LAMA1;LAMC2;C8G
TuberculosisCAP18;CAMK2D;VDR;TNFRSF1A;ITGAX;IFNA2;KSR1;BAD;IFNA8
Hepatitis CTNFRSF1A;CLDN10;RIPK1;PIK3CD;OAS1A;RNASEL;KRAS;PPP2R2C;PIAS1
Hepatitis BIFNA17;CREB3L1;ATP6AP1;STAT5B;CCNE1;MAVS;Ifna11;CCNA2;KRAS
MeaslesOAS1A;IFNA13;CD28;FCGR2B;EIF2AK1;IFNA14;CCND3;EIF3H;TNFRSF10D
Influenza ALOC780933;ACTB;GSK3B;EP300;PABPN1;PIK3CG;ADAR;TYK2;PRKCB
HTLV-I infectionCD3E;WNT3;Fzd4;SLC25A6;FZD1;CDC23;ATF3;TCF3;NFKB2
Herpes simplex infectionMAPK8A;HLA-DQA2;CYCS;HLA-DOB;H2-AB1;RELA;IFNA1;SRSF6B;PVRL1B
Epstein-Barr virus infectionTRP53;TRAF2;RBPJ;TBPL1;TBK1;POLR3F;CD58;AKAP8L;SKP2
Pathways in cancerFGF6;TRAF1;PLCG1;ITGA2;FGF8;Casp3;GNG7;ARAF;HGF
Transcriptional misregulation in cancerNFKBIZ;Aff1;MAX;ZEB1;NGFR;SPINT1;FUS;PFTK1;CLSTN2
Viral carcinogenesisMDM2;GTF2H3;PXN;HIST1H4F;GTF2E1;HLA-C;CCNE1;GTF2A1;NRAS
Pancreatic cancerBRCA2;SMAD3;PIK3R1;BCL2L1;MAPK1;RELA;PLD1;RALGDS;CDC42
Prostate cancerCCND1;PDPK1;HSP90AA1;IKBKG;HSP90AB1;CPN1;AKT1;PIK3R1;FGFR2
Chronic myeloid leukemiaPIK3CD;KRAS;PIK3R5;TRP53;TGFB1;CCND1;RELA;RAF1;IKBKG
Acute myeloid leukemiaAKT2;MYC;SOS1;LEF1;PIK3R5;SFPI1;IKBKB;SPI1;CEBPA
Small cell lung cancerBCL2L1;ITGB1;IKBKB;TRAF6;PIK3CD;PIK3R5;BIRC2;ITGA6;TRAF5
Inflammatory bowel disease (IBD)HLA-DQA2;IL23;IL17A;IL4;TGFB2;IFNGR2;HLA-DQA1;HLA-DQB1;RORC

RELA has several biochemical functions, for example, DNA binding, NF-kappaB binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RELA itself. We selected most functions RELA had, and list some proteins which have the same functions with RELA. You can find most of the proteins on our site.

Function Related Protein
DNA bindingMXD3;HIST2H2AC;KIN;DNAJB6;ZNF266;CTC1;MSXB;HIST1H4L;ZNF358
NF-kappaB bindingCDK5RAP3;HDAC2;EP300;SNAI1A;HIF1AN;MTDH;AP1S2;BCL10;BRMS1
RNA polymerase II core promoter proximal region sequence-specific DNA bindingMSX2;ZNF100;HOXA5;FEZF2;AKNA;RBPJL;BATF2;SRF;FOXJ1
RNA polymerase II distal enhancer sequence-specific DNA bindingHNRNPC;SPI1;SFPQ;NR5A1;CDX1;NR5A2;GZF1;CDX2;ZBTB16
RNA polymerase II regulatory region sequence-specific DNA bindingHES6;KLF12;ALX1;IKZF5;ATF4B1;TBX5;SOX13;GFI1AA;CREB3
actinin bindingPKD2;MICALL2;NFKB1;TTN;PDLIM5;PROM1;CSRP3;RELA
activating transcription factor bindingTAF9;MEF2A;EP300;HDAC1;HDAC7A;RELA;SMAD2;ZFP516;GATA4
ankyrin repeat bindingRELA;SHANK1;HIF1AN
chromatin DNA bindingAPEX1;RARA;PPARGC1A;GRHL3;HIST1H1E;INSM1B;RELA;AASS;H2AFZ
chromatin bindingLDB1;BAZ1B;NEUROD1;PAX3;NOC3L;RBPJL;HMGXB4;BAHD1;NFATC3
histone deacetylase bindingNKX3;MAGEA2;CEBPA;BCOR;KLF4;HDAC3;PKN1;HDAC1;BRMS1LA
identical protein bindingGOT1;CCT7;RELA;BTK;BNIP3;KDM6A;ALS2CL;ATXN10;SCUBE1
phosphate ion bindingSH2B3;G6PC;RELA;RPH3A;MTHFD2;CHST14;ADSS;SLC34A2;OTC
protein N-terminus bindingSTX5A;TAF11;SMARCE1;ACOX1;SERPINB1A;CSNK2A2;NIPBL;CHMP6;SCT
protein bindingMKKS;LINGO1B;NCOA5;KCNA3;INTS7;SPAT-1;IMP3;Artn;Icosl
protein complex bindingCDH2;FYB;NASP;ATP6V0D1;FADD;HTR2A;DLG4;NCKAP1;NCKAP1L
protein heterodimerization activityHIST1H2BA;GM5506;SIM1;BHLHE40;PVALB;TRP53;H2AFX;ITGB1A;ATF4
protein homodimerization activityAGXT;ERCC5;GSTA4;LRRK2;GPD1L;MCL1;CBLN1;SLC6A4;SNX9
protein kinase bindingEEF1A2;RB1CC1;MAVS;GCSAM;AGTR1A;RAB8A;CAMK2N2;VRK1;FGR
repressing transcription factor bindingARNTL;HHEX;MYC;EIF4E;SRI;CBX5;NOC2L;TLE4;RELA
transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingNKX2;CEBPB;MYOD1;FOXC2;T;POU3F1;NFATC1;ZFHX3;SFPI1
transcription factor activity, sequence-specific DNA bindingZFP11;TEAD4;MEF2D;NFIL3-3;NR2F2;NR2F1B;HOMEZB;OTX1B;POU5F2
transcription factor bindingNR0B1;PIANP;SMARCA4;TCF7L2;MDFIC;MED25;RARA;TRIB1;CEBPA
transcription regulatory region DNA bindingTAL1;TCF7L1B;CREB3L2;ERBB4;H2AFY2;FOXA2;CTCF;TAF9;ZNF831
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingATF2;HOXA10;ARNT2;MEIS3;GRHL1;PITX2;RFX4;LEF1;NR4A1
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific bindingARID3B;BACH1;REL;MEOX2;NFKB1;FUBP1;PROP1;TARDBP;PBX3
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific bindingBATF3;NFIL3-6;NFATC4;CC2D1B;NKX6-2;PRDM5;SNAI1;YY1;SNAI2
ubiquitin protein ligase bindingRELA;UBE2KB;TMBIM6;ABI2;CUL1;TRIOBP;HSPA9;CUL3B;TCEB2

RELA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RELA here. Most of them are supplied by our site. Hope this information will be useful for your research of RELA.

NFKBIA

Yang, HJ; Wang, M; et al. NF-kappa B Regulates Caspase-4 Expression and Sensitizes Neuroblastoma Cells to Fas-Induced Apoptosis. PLOS ONE 10:-(2015).
Chen, Y; Lu, RQ; et al. The NFKB1 polymorphism (rs4648068) is associated with the cell proliferation and motility in gastric cancer. BMC GASTROENTEROLOGY 15:-(2015).
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