STAT6

  • Official Full Name

    signal transducer and activator of transcription 6, interleukin-4 induced

  • Overview

    The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
  • Synonyms

    STAT6; signal transducer and activator of transcription 6, interleukin-4 induced; STAT6B; STAT6C; D12S1644; IL-4-STAT; signal transducer and activator of transcription 6; STAT, interleukin4-induced; transcription factor IL-4 STAT;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human Cells
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|MBP
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human STAT6-344H Recombinant Human STAT6 protein, His/MBP-tagged E.coli His/MBP
Human STAT6-4889H Recombinant Human Signal Transducer And Activator Of Transcription 6, GST-tagged Sf9 Insect Cell GST
Human STAT6-7039H Recombinant Human STAT6, His tagged Insect Cell His
Human STAT6-30854TH Recombinant Human STAT6, His-tagged E.coli His
Human STAT6-707H Recombinant Human STAT6 Protein, His-tagged E.coli His
Human STAT6-481HCL Recombinant Human STAT6 cell lysate Insect Cell N/A
Human STAT6-6368H Recombinant Human STAT6 Protein (Ser627-Ser837), C-His tagged E.coli C-His
Human STAT6-2916H Recombinant Human STAT6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human STAT6-151H Recombinant Human STAT6 Protein, His-tagged Human Cells His
Human STAT6-2897H Recombinant Human STAT6 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human STAT6-888HFL Recombinant Full Length Human STAT6 Protein, C-Flag-tagged Mammalian cells Flag
Human STAT6-2119H Recombinant Human STAT6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human STAT6-2119H-B Recombinant Human STAT6 Protein Pre-coupled Magnetic Beads HEK293
Mouse Stat6-1731M Recombinant Mouse Stat6 protein, His & T7-tagged E.coli His/T7
Mouse STAT6-16113M Recombinant Mouse STAT6 Protein Mammalian Cell His
Mouse STAT6-8789M Recombinant Mouse STAT6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse STAT6-8789M-B Recombinant Mouse STAT6 Protein Pre-coupled Magnetic Beads HEK293
Mouse Stat6-6174M Recombinant Mouse Stat6 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Stat6-1732R Recombinant Rat Stat6 protein, His & T7-tagged E.coli His/T7
Rat Stat6-4312R Recombinant Rat Stat6 Protein (Gly557-Trp841), N-His tagged E.coli N-His
Rhesus Macaque STAT6-4519R Recombinant Rhesus monkey STAT6 Protein, His-tagged Mammalian Cell His
Rhesus Macaque STAT6-4335R-B Recombinant Rhesus Macaque STAT6 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque STAT6-4335R Recombinant Rhesus Macaque STAT6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish STAT6-7074Z Recombinant Zebrafish STAT6 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • STAT6 Related Articles
  • STAT6 Related Gene Family
  • STAT6 Related Research Area
  • STAT6 Related Signal Pathway

STAT6 involved in several pathways and played different roles in them. We selected most pathways STAT6 participated on our site, such as Jak-STAT signaling pathway, Hepatitis B, Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with STAT6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Jak-STAT signaling pathwayCCND2;IFNAR2;SOCS5B;IFNGR1;IL12BA;EPOR;Il23a; Il12b;SOCS3;IL29
Hepatitis BCREB3L2;KRAS;PIK3R1;IFNA5;CASP10;Casp3;TLR2;PIK3R2;YWHAZ
Inflammatory bowel disease (IBD)HLA-DRB3;IL21R;HLA-DQA2;HLA-DPB1;FOXP3;IFNG;TBX21;HLA-DMA;HLA-DOA

STAT6 has several biochemical functions, for example, RNA polymerase II core promoter sequence-specific DNA binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STAT6 itself. We selected most functions STAT6 had, and list some proteins which have the same functions with STAT6. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II core promoter sequence-specific DNA bindingTCF7L2;TAL1;WBP2;ZFP335;SP3;ZNF335;H2AFZ;SMAD5;H2AFY
identical protein bindingHOMER1;GOT2A;ZNF703;VWA1;NQO1;BNIP3L;RBM10;CCL4;CORO1B
protein bindingVAMP5;ORAI2;RPS6KB1;TLR2;ADAMTS10;ICK;CLPX;FKBP7;C12orf68
protein phosphatase bindingSNX3;PPP1R3G;VCAN;TRP53;HSF4;VCP;PIK3R1;PPARG;SHOC2
signal transducer activityOLFR8;DKKL1;C18orf32;PLEKHB1;SECTM1;STAT1B;CXCR4A;IL10RA;TRIM54
transcription factor activity, sequence-specific DNA bindingZNF215;MAFBB;ZFP1;ZNF43;KLF4;HOXB3A;BTBD8;ZNF155;GTF2IRD1

STAT6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STAT6 here. Most of them are supplied by our site. Hope this information will be useful for your research of STAT6.

IL4R; TMEM173; TBK1

van Slambrouck, C; Huh, J; et al. Nuclear Staining for Stat6 With the YE361 Monoclonal Antibody Is Restricted To Classical Hodgkin Lymphoma. MODERN PATHOLOGY 28:382A-383A(2015).
van Slambrouck, C; Huh, J; et al. Nuclear Staining for Stat6 With the YE361 Monoclonal Antibody Is Restricted To Classical Hodgkin Lymphoma. LABORATORY INVESTIGATION 95:382A-383A(2015).
  • Q&As
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Reviews
10/23/2018

    I am particularly impressed by STAT6 protein's versatility and reliability across different experimental techniques, showcasing its robustness and suitability for a wide range of research applications.

    11/20/2016

      Its excellent performance in this application makes it a valuable asset in immunoassays and other biochemical studies.

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