|Official Full Name||signal transducer and activator of transcription 6, interleukin-4 induced|
|Background||The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]|
|Synonyms||STAT6; signal transducer and activator of transcription 6, interleukin-4 induced; STAT6B; STAT6C; D12S1644; IL-4-STAT; signal transducer and activator of transcription 6; STAT, interleukin4-induced; transcription factor IL-4 STAT;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
stat6 involved in several pathways and played different roles in them. We selected most pathways stat6 participated on our site, such as Jak-STAT signaling pathway, Hepatitis B, Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with stat6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Jak-STAT signaling pathway||IL24; JAK2A; PRP2; RNF207B; IFNA16; FHL1; PIAS4; PRLRA; GHR; CSH2|
|Hepatitis B||EGR3; STAT6; NFATC2; EGR2; FADD; IFNA13; STAT4; CXCL8; TGFB2; CASP12|
|Inflammatory bowel disease (IBD)||TBX21; IL12RB2; SMAD3; RORA; IL23R; HLA-DRA; IL5; IL18; IL23; STAT6|
stat6 has several biochemical functions, for example, RNA polymerase II core promoter sequence-specific DNA binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by stat6 itself. We selected most functions stat6 had, and list some proteins which have the same functions with stat6. You can find most of the proteins on our site.
|RNA polymerase II core promoter sequence-specific DNA binding||RUVBL2; FOS; SP3; SOX8; HNF4A; TRP53; EP300; SUZ12; ZNF335; RBPJ|
|identical protein binding||VWA2; TRAF6; PPP5C; PAFAH1B3; ERBB3; TYROBP; CLDN11; C1QTNF9; ANXA4; ERBB2|
|protein binding||C14orf135; PGM1; PRPF6; UBXN1; POU3F2; TGFBI; INTS10; GPR125; EIF1AD; CPT1C|
|protein phosphatase binding||PARD3; RPA2; JUPA; VRK3; GRB2; PPP1R3C; IRS2; ANAPC7; STAT3; PIK3R1|
|signal transducer activity||OLFR480; MIER1A; TAAR12J; OLFR491; LPAR2B; GPR183A; OLFCW1; TRHRB; ATP2C1; OLFR24|
|transcription factor activity, sequence-specific DNA binding||SLC26A3; ZFP30; FOXG1B; MYOG; ZFP367; HOXB4A; SNAPC4; ZNF207; ZXDC; MYC|
stat6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with stat6 here. Most of them are supplied by our site. Hope this information will be useful for your research of stat6.
IL4R; TMEM173; TBK1