STAT6 Protein


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Official Full Name signal transducer and activator of transcription 6, interleukin-4 induced
Background The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Synonyms STAT6; signal transducer and activator of transcription 6, interleukin-4 induced; STAT6B; STAT6C; D12S1644; IL-4-STAT; signal transducer and activator of transcription 6; STAT, interleukin4-induced; transcription factor IL-4 STAT;
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cells
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • MBP
    • T7
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human STAT6-30854TH Recombinant Human STAT6, His-tagged E.coli His
    Human STAT6-344H Recombinant Human STAT6 protein, His/MBP-tagged E.coli His/MBP
    Human STAT6-4889H Recombinant Human Signal Transducer And Activator Of Transcription 6, GST-tagged Sf9 Insect Cell GST
    Human STAT6-7039H Recombinant Human STAT6, His tagged Insect Cell His
    Human STAT6-707H Recombinant Human STAT6 Protein, His-tagged E.coli His
    Mouse STAT6-16113M Recombinant Mouse STAT6 Protein Mammalian Cell His
    Mouse Stat6-1731M Recombinant Mouse Stat6 protein, His & T7-tagged E.coli His/T7
    Rat Stat6-1732R Recombinant Rat Stat6 protein, His & T7-tagged E.coli His/T7
    Rhesus Macaque STAT6-4519R Recombinant Rhesus monkey STAT6 Protein, His-tagged Mammalian Cell His
    Zebrafish STAT6-7074Z Recombinant Zebrafish STAT6 Mammalian Cell His
    Human STAT6-481HCL Recombinant Human STAT6 cell lysate Insect Cell N/A
    Human STAT6-151H Recombinant Human STAT6 Protein, His-tagged Human Cells His
    Human STAT6-2897H Recombinant Human STAT6 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human STAT6-2916H Recombinant Human STAT6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Stat6-6174M Recombinant Mouse Stat6 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    STAT6 involved in several pathways and played different roles in them. We selected most pathways STAT6 participated on our site, such as Jak-STAT signaling pathway, Hepatitis B, Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with STAT6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Jak-STAT signaling pathway SOCS3B; IL12B; IL15RA; IL11RA2; CRFB16; IL20RB; PTPN2B; PIK3R3A; IFNA10; IL22RA1
    Hepatitis B PIK3R2; DDB2; AKT1; IFNA12; IFIH1; IFNA1; STAT2; RELA; GRB2; IFNA2
    Inflammatory bowel disease (IBD) HLA-DQA1; HLA-DMB; NFATC1; Il4ra; Il2; TLR2; IL23R; NFKB1; IL23; RORA

    STAT6 has several biochemical functions, for example, RNA polymerase II core promoter sequence-specific DNA binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STAT6 itself. We selected most functions STAT6 had, and list some proteins which have the same functions with STAT6. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter sequence-specific DNA binding STAT6; GATA6; SMYD3; ZFP335; H3F3B; FOS; SUZ12; SOX3; GATA1; GATA3
    identical protein binding RASSF1; TRAF2; UBQLN4; VEGFA; NPR2; L1CAM; APLP2; ZHX2; GRIK5; GBP1
    protein binding ALAS1; FOXP2; FBXO44; JUB; IRF7; ALOX15; IL12A; TSGA10IP; ANXA2; FBXO32
    protein phosphatase binding PPARG; RPA3; RPA2; CSK; Itga10&Itgb1; ANAPC4; PIK3R2; ITPR1; TP53; KAT2A
    signal transducer activity MRGPRB8; PLCH1; GNG12A; OLFR477; CTNNB1; PLCZ1; GPR177; GNG11; S1PR5A; SLC35B2
    transcription factor activity, sequence-specific DNA binding RAB11FIP4A; JUNBB; HMGA1; ZNF7; POU2F2; NTNG1; SS18L1; RARAA; ZFP518A; MEF2B

    STAT6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STAT6 here. Most of them are supplied by our site. Hope this information will be useful for your research of STAT6.

    IL4R; TMEM173; TBK1

    van Slambrouck, C; Huh, J; et al. Nuclear Staining for Stat6 With the YE361 Monoclonal Antibody Is Restricted To Classical Hodgkin Lymphoma. MODERN PATHOLOGY 28:382A-383A(2015).
    van Slambrouck, C; Huh, J; et al. Nuclear Staining for Stat6 With the YE361 Monoclonal Antibody Is Restricted To Classical Hodgkin Lymphoma. LABORATORY INVESTIGATION 95:382A-383A(2015).

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