THBS1

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THBS1

Official Full Name thrombospondin 1
Background The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]
Synonyms THBS1; thrombospondin 1; TSP; THBS; TSP1; TSP-1; THBS-1; thrombospondin-1; thrombospondin-1p180
    • Species :
    • Cattle
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human plasma
    • Human Platelet
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Tag :
    • His
    • T7
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human THBS1-1101HCL Recombinant Human THBS1 293 Cell Lysate HEK293 N/A
    Human THBS1-185H Recombinant Human Thrombospondin 1 Insect Cell N/A
    Human THBS1-2657H Recombinant Human THBS1 protein, His-tagged E.coli His
    Human THBS1-31513TH Recombinant Human THBS1 protein, glycosylated Insect Cell N/A
    Human THBS1-31514TH Native Human THBS1 N/A
    Human THBS1-31515TH Native Human THBS1 N/A
    Human THBS1-31516TH Recombinant Human THBS1 E.coli N/A
    Human THBS1-355H Recombinant Human THBS1 Protein, His-tagged HEK293 His
    Human THBS1-4946H Native Human Thrombospondin protein Human Platelet N/A
    Human THBS1-5524H Natve Human Thrombospondin Human plasma N/A
    Human THBS1-894H Recombinant Human THBS1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse Thbs1-2658M Recombinant Mouse Thbs1 protein, His-tagged E.coli His
    Mouse Thbs1-2659M Recombinant Mouse Thbs1 protein, His-tagged E.coli His
    Mouse Thbs1-2660M Recombinant Mouse Thbs1 protein, His-tagged E.coli His
    Mouse Thbs1-6407M Recombinant Mouse Thbs1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Thbs1-659M Recombinant Mouse Thbs1 Mammalian cells N/A
    Rat Thbs1-2661R Recombinant Rat Thbs1 protein, His-tagged E.coli His
    Rat Thbs1-2662R Recombinant Rat Thbs1 protein, His-tagged E.coli His
    Rat Thbs1-2663R Recombinant Rat Thbs1 protein, His-tagged E.coli His
    Rat Thbs1-2664R Recombinant Rat Thbs1 protein, His-tagged E.coli His
    Chicken THBS1-4319C Recombinant Chicken THBS1 Mammalian Cell His
    Cattle THBS1-2656C Recombinant Cattle THBS1 protein, His & T7-tagged E.coli His/T7
    CDA101 Thrombospondin-1 Peptide Antigen N/A

    THBS1 involved in several pathways and played different roles in them. We selected most pathways THBS1 participated on our site, such as Rap signaling pathway, p signaling pathway, Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with THBS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Rap signaling pathway GNAI3; RAP1GAP; MAPK13; FGF13; MAGI1; FGFR2; CALML3; PIK3R1; CALM4; Itgam&Itgb2
    p signaling pathway CCNB3; TP53; ZMAT3; PTEN; SESN2; STEAP3; CCND2; CCNE1; Casp3; PTENA
    Phagosome TUBA3B; ATP6V0E1; ATP6V1F; THBS2; ATP6V0C; ATP6V0CB; TFR1A; CALRL2; CD209B; RAC1B
    PIK-Akt signaling pathway FGF8; ITGA5; GNGT1; TLR2; SGK3; CREB3L3; THBS3; PPP2R5A; PPP2R2C; IL2RB
    TGF-beta signaling pathway TNF; TGFBR2; EP300; CUL1B; NOG3; BMP7B; SMAD2; INHBAB; TGFB1A; SMURF1
    Focal adhesion LAMB3; IBSP; COL2A1B; MYLPF; MAPK1; PIK3CD; COL6A1; ITGB7; MYL2; ITGB1A
    ECM-receptor interaction SDC4; ITGA6; COL11A1A; CD44; TNW; ITGA8; COL4A3; ITGB5; ITGAV; GP1BB
    Malaria IL-8; LRP1; CD81; MYD88; THBS2; TGFB3; HBB-B2; ITGAL; CCL2; IL6
    Proteoglycans in cancer DROSHA; MAPK1; CBL; MAPK12; CBLC; PAK1; ITGB5; GRB2; Fasl; PPP1R12C
    MicroRNAs in cancer APC; MAP2K2; IKBKB; ABCC1; CCND1; EP300; HMOX1; CCND2; TTC6; PRKCG
    Bladder cancer MMP1; TP53; MMP1A; MAP2K1; MYC; IL-8; CDK4; MAPK3; ERBB2; RB1

    THBS1 has several biochemical functions, for example, calcium ion binding, collagen V binding, fibrinogen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by THBS1 itself. We selected most functions THBS1 had, and list some proteins which have the same functions with THBS1. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding ZZEF1; SLC24A2; aLA; LPCAT2; KCNIP3; SNCB; RCVRN; VCAN; SPARCL1; GSN
    collagen V binding ECM2; THBS1
    fibrinogen binding FBLN1; THBS1; ITGA2B; MFAP2
    fibroblast growth factor binding FGFR2; KLB; SCN5A; HSPA9; GLG1; RPS19; FIBPA; CXCL13; Api5; FIBPB
    fibronectin binding ITGB3; CTGF; THBS1; IGFBP3; VEGFA; HSD17B12; LACRT; IGFBP5; CTSL1; CTSS
    glycoprotein binding TFR2; ITGB2; SERPINA1; SDC1; IGF2R; Itgam&Itgb2; F7; SELP; ERLEC1; FBXO17
    heparin binding CTGFB; ZFP207; HRG; SLIT1; KNG1; CXCL10; FMODA; APOA5; CCL15; APLP1
    identical protein binding ADIPOR1; CORO1B; BAX; PCBD1; SRPX2; GRIN3A; HJURP; SOD1; STAC3; CCT7
    integrin binding S1PR2; ITGB5; EGFL6; CXADR; GFAP; ACTN2; FERMT3; FBN1; PTPN2; TSPAN8
    laminin binding NID1; CTSS; LGALS3; ACHE; GPC1; BCAM; RPSA; NCL; ITGB1; ITGA9
    low-density lipoprotein particle binding LDLR; CDH13; COLEC12; LIPC; ANKRA2; PCSK9; SCARB1; SCARF1; MSR1; THBS1
    phosphatidylserine binding SDPR; RASGRP1; CD300A; THBS1; GAP43; AXL; CPNE6; JPH2; SCARB1; ANXA9
    protein binding BRD7; RAB13; MLF1IP; TUFT1; ZNF193; NR5A1; CLK1; TBC1D7; PTS; TOP2A
    proteoglycan binding SLIT2; CTSL1; FCN2; CTSK; CTSS; CECR1A; CTSB; UBE4A; COL5A1; THBS1
    transforming growth factor beta binding VASN; LTBP4; ITGAV; HYAL2; TGFBR2; LTBP1; TGFBR1; ACVR1; CD109; ACVRL1

    THBS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with THBS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of THBS1.

    PCOLCE; TGFB1; PLEK; chondroitin_sulfate; dermatan_sulfate; heparin; heparan_sulfate; collagen_i_human; collagen_xi_human; collagen_vi_human; FN1; APP; Col11a1; BGN; TGM2

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