Recombinant Mouse Tnfrsf11b Protein, His-tagged

• Cat.No.: Tnfrsf11b-7291M
• Product Overview: Recombinant Mouse Tnfrsf11b Protein with a His tag.

Specification

• Description: Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
• Species: Mouse
• Tag: His
• Form: Liquid
• Molecular Mass: 44.4 kDa
• Protein length: 22-401
• AA Sequence: ETLPPKYLHYDPETGHQLLCDKCAP GTYLKQHCTVRRKTLCVPCPDHSYT DSWHTSDECVYCSPVCKELQSVKQE CNRTHNRVCECEEGRYLEIEFCLKH RSCPPGSGVVQAGTPERNTVCKKCP DGFFSGETSSKAPCIKHTNCSTFGL LLIQKGNATHDNVCSGNREATQKCG IDVTLCEEAFFRFAVPTKIIPNWLS VLVDSLPGTKVNAESVERIKRRHSS QEQTFQLLKLWKHQNRDQEMVKKII QDIDLCESSVQRHLGHSNLTTEQLL ALMESLPGKKISPEEIERTRKTCKS SEQLLKLLSLWRIKNGDQDTLKGLM YALKHLKTSHFPKTVTHSLRKTMRF LHSFTMYRLYQKLFLEMIGNQVQSV KISCLLEHHHHHH
• Endotoxin: < 1.0 EU/μg of protein (determined by LAL method)
• Purity: > 90 % by SDS-PAGE
• Stability: Shelf life: one year from despatch.
• Storage: Store undiluted at 2-8 centigrade for one week or (in aliquots) at -20 to -80 centigrade for longer. Avoid repeated freezing and thawing.
• Concentration: 0.25 mg/mL (determined by absorbance at 280nm)
• Storage Buffer: Phosphate Buffered Saline (pH 7.4) containing 10 % glycerol.

Gene Information

• Gene Name: Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) [ Mus musculus (house mouse) ]
• Official Symbol: Tnfrsf11b
• Synonyms: Tnfrsf11b; tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin); O; OC; TR; Opg; TR1; OCIF; tumor necrosis factor receptor superfamily member 11B; osteoclastogenesis inhibitory factor; osteoprotegerin
• Gene ID: 18383
• mRNA Refseq: NM_008764
• Protein Refseq: NP_032790
• UniProt ID: O08712