| Species : |
Human |
| Source : |
Mammalian Cells |
| Tag : |
Fc |
| Description : |
Transmembrane activator & calcium modulator and cyclophilin ligand (CAML) interactor (TACI) is lymphocyte specific member of the tumor necrosis factor-receptor superfamily and is expressed in B-lymphocytes and may act to regulate humoral immunity. TACI also serves as a receptor for B-cell activating factor of the TNF family (BAFF) and as a proliferation-inducing ligand (APRIL). |
| Molecular Weight : |
The recombinant mature human TACI/Fc is a disulfide-linked homodimeric protein. Based on N-terminal sequencing, the recombinant protein has Ser 2 of human TACI at the amino-terminus. The reduced human TACI/Fc monomer has a calculated molecular mass of 45.2 kDa. In SDS-PAGE, the recombinant TACI/Fc preparation showed an approximately 51 kDa band and an approximately 40 kDa doublet. The presence of multiple bands in the preparation is likely the result of heterogenous glycosylation. |
| State Of Matter : |
Lyophilized. |
| Purity : |
>90% by SDS Page and analyzed by silver stain. |
| Endotoxin : |
<0.1 ng per 1 µg as determined by the LAL method. |
| Biological Activity : |
The biological activity of Human Transmembrane Activator and CAML Interactor is determined by its ability to block human BAFF induced T2B cell survival assay using a concentration range of 1.0-3.0 ug/ml. |
| Storage And Stability : |
This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. |
