Recombinant Human TACI, Fc-tagged (Atacicept)

• Cat.No.: TNFRSF13B-P05H
• Product Overview: The protein combines the binding site for two cytokines that regulate maturation, function, and survival of B cells, B-lymphocyte stimulator (BLyS) and a proliferation-inducing ligand (APRIL), with the constant region of immunoglobin. It blocks activation of B cells by the tumor necrosis factor receptor superfamily member 13B (more commonly known as TACI), a transmembrane receptor protein found predominantly on the surface of B cells. Like the monoclonal antibody belimumab, atacicept blocks the binding of BLyS, but it also blocks APRIL. Binding of these TACI ligands induces proliferation, activation, and longevity of B cells and thus their production of autoantibodies. The protein is thought to selectively impair mature B cells and plasma cells with less impact on progenitor cells and memory B cells.

Specification

• Species: Human
• Tag: Fc
• CAS number: 845264-92-8
• Endotoxin: < 0.1 eu per μg of the
• Purity: >95%

Gene Information

• Gene Name: TNFRSF13B tumor necrosis factor receptor superfamily, member 13B [ Homo sapiens ]
• Official Symbol: TNFRSF13B
• Synonyms: TNFRSF13B; tumor necrosis factor receptor superfamily, member 13B; tumor necrosis factor receptor superfamily member 13B; CD267; TACI; tumor necrosis factor receptor 13B; transmembrane activator and CAML interactor; CVID; CVID2; TNFRSF14B; FLJ39942; MGC39952; MGC133214
• Gene ID: 23495
• mRNA Refseq: NM_012452
• Protein Refseq: NP_036584
• MIM: 604907
• UniProt ID: O14836
• Chromosome Location: 17p11.2
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem; Primary immunodeficiency, organism-specific biosystem; Primary immunodeficiency, conserved biosystem; Syndecan-2-mediated signaling events, organism-specific biosystem
• Function: protein binding; receptor activity