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Recombinant Human TACI, Fc-tagged (Atacicept)

Cat.No. : TNFRSF13B-P05H
Product Overview : The protein combines the binding site for two cytokines that regulate maturation, function, and survival of B cells, B-lymphocyte stimulator (BLyS) and a proliferation-inducing ligand (APRIL), with the constant region of immunoglobin. It blocks activation of B cells by the tumor necrosis factor receptor superfamily member 13B (more commonly known as TACI), a transmembrane receptor protein found predominantly on the surface of B cells. Like the monoclonal antibody belimumab, atacicept blocks the binding of BLyS, but it also blocks APRIL. Binding of these TACI ligands induces proliferation, activation, and longevity of B cells and thus their production of autoantibodies. The protein is thought to selectively impair mature B cells and plasma cells with less impact on progenitor cells and memory B cells.
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  • Gene Information
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Species : Human
CAS number : 845264-92-8
Endotoxin : < 0.1 eu per μg of the
Purity : >95%
Gene Name : TNFRSF13B tumor necrosis factor receptor superfamily, member 13B [ Homo sapiens ]
Official Symbol : TNFRSF13B
Synonyms : TNFRSF13B; tumor necrosis factor receptor superfamily, member 13B; tumor necrosis factor receptor superfamily member 13B; CD267; TACI; tumor necrosis factor receptor 13B; transmembrane activator and CAML interactor; CVID; CVID2; TNFRSF14B; FLJ39942; MGC39952; MGC133214;
Gene ID : 23495
mRNA Refseq : NM_012452
Protein Refseq : NP_036584
MIM : 604907
UniProt ID : O14836
Chromosome Location : 17p11.2
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem; Primary immunodeficiency, organism-specific biosystem; Primary immunodeficiency, conserved biosystem; Syndecan-2-mediated signaling events, organism-specific biosystem;
Function : protein binding; receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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