Recombinant Monkey TNFSF4 Protein, Fc-tagged, Alexa Fluor 555 conjugated

• Cat.No.: TNFSF4-67CAF555
• Product Overview: Alexa Fluor 555 conjugated recombinant Monkey TNFSF4 (F7FL80) (Gln51-Leu183), fused with the Fc region of mouse IgG1 at the N-terminus, was produced in Human Cells.

Specification

• Source: HEK293
• Species: Monkey
• Tag: Fc
• Form: Lyophilized
• Molecular Mass: The recombinant cynomolgus TNFSF4 is a disulfide-linked homodimer. The reduced monomer comprises 369 amino acids and has a calculated molecular mass of 42 kDa.The apparent molecular mass of it is approximately 48 kDa respectively in SDS-PAGE.
• Protein length: 369
• N-terminal Sequence Analysis: Asp
• Endotoxin: < 1.0 EU/ μg of the protein as determined by the LAL method.
• Purity: > 85 % as determined by SDS-PAGE
• Characteristic: Disulfide-linked homodimer
  Labeled with Alexa Fluor 555 via amines
  With an excitation and emission maximum of 555/565 nm, Alexa Fluor 555 can be efficiently excited using a 543 nm He-Ne laser line and detected under standard TRITC/Cy3 filters.
• Stability: Samples are stable for up to 12 months from date of receipt at -70 centigrade.
• Storage: Store it under sterile conditions at -20 to -70 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution. Centrifuge the vial at 4 centigrade before opening to recover the entire contents.

Gene Information

• Gene Name: TNFSF4tumor necrosis factor (ligand) superfamily, member 4 [Macaca fascicularis(crab-eating macaque) ]
• Official Symbol: TNFSF4
• Gene ID: 102141877
• mRNA Refseq: XM_005540022
• Protein Refseq: XP_005540079

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Q&As

How do genetic variations in TNFSF4 affect immune function?

Genetic changes in TNFSF4 affect immune regulation and autoimmune disease susceptibility.

What is the primary role of TNFSF4 in immune system regulation?

TNFSF4 (OX40L) regulates immune responses and T-cell activation.

How does TNFSF4 contribute to inflammatory responses?

It activates T-cells, stimulating inflammatory cytokine production.

What role does TNFSF4 play in autoimmune disorders?

TNFSF4 is implicated in autoimmune disease development by promoting immune cell activation.

How does TNFSF4 interact with other cytokines and receptors in the immune system?

TNFSF4 interacts with OX40 and other receptors, influencing immune signaling.

What potential therapeutic applications arise from targeting TNFSF4 in immune-related diseases?

Targeting TNFSF4 could treat autoimmune and inflammatory diseases by modulating the immune system.

What is the impact of altered TNFSF4 activity on chronic inflammation?

Altered TNFSF4 activity contributes to chronic inflammation.