Recombinant Human TNFSF4 Protein, Fc-tagged, FITC conjugated

• Cat.No.: TNFSF4-491HF
• Product Overview: FITC conjugated recombinant human TNFSF4(Gln51-Leu183) fused with Fc region of human IgG1 at the N-terminus was expressed in HEK293.

Specification

• Description: OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecule that plays a crucial role in the regulation of T-cell-mediated immunity. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. OX-40L is a ligand for receptor TNFRSF4/OX4. It is found to play a role in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.
• Source: HEK293
• Species: Human
• Tag: Fc
• Form: Lyophilized
• Molecular Mass: 46.6 kDa
• Protein length: Gln51-Leu183， 412
• N-terminal Sequence Analysis: Glu
• Endotoxin: < 1.0 EU/ μg protein as determined by the LAL method.
• Purity: > 95 % as determined by SDS-PAGE
• Characteristic: Disulfide-linked homodimer
  Labeled with FITC via amines
  Excitation source: 488 nm spectral line, argon-ion laser
  Excitation Wavelength: 488 nm
  Emission Wavelength: 535 nm
• Stability: Samples are stable for up to 12 months from date of receipt at -70 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
• Shipping: Shipped at ambient temperature.
  Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Gene Information

• Gene Name: TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 [ Homo sapiens ]
• Official Symbol: TNFSF4
• Synonyms: TNFSF4; tumor necrosis factor (ligand) superfamily, member 4; tax transcriptionally activated glycoprotein 1, 34kD , TXGP1; tumor necrosis factor ligand superfamily member 4; CD252; gp34; OX 40L; OX40L; CD134 ligand; glycoprotein Gp34; OX40 antigen ligand; TAX transcriptionally-activated glycoprotein 1; tax-transcriptionally activated glycoprotein 1 (34kD); GP34; OX4OL; TXGP1; CD134L; OX-40L
• Gene ID: 7292
• mRNA Refseq: NM_003326
• Protein Refseq: NP_003317
• MIM: 603594
• UniProt ID: P23510

Reviews

12/28/2022

Efficient service, accelerates research productivity.

05/13/2018

Outstanding accuracy, essential for research quality.

02/12/2018

Trusted for research integrity, a critical research asset.

Q&As

How do genetic variations in TNFSF4 affect immune function?

Genetic changes in TNFSF4 affect immune regulation and autoimmune disease susceptibility.

What is the primary role of TNFSF4 in immune system regulation?

TNFSF4 (OX40L) regulates immune responses and T-cell activation.

How does TNFSF4 contribute to inflammatory responses?

It activates T-cells, stimulating inflammatory cytokine production.

What role does TNFSF4 play in autoimmune disorders?

TNFSF4 is implicated in autoimmune disease development by promoting immune cell activation.

How does TNFSF4 interact with other cytokines and receptors in the immune system?

TNFSF4 interacts with OX40 and other receptors, influencing immune signaling.

What potential therapeutic applications arise from targeting TNFSF4 in immune-related diseases?

Targeting TNFSF4 could treat autoimmune and inflammatory diseases by modulating the immune system.

What is the impact of altered TNFSF4 activity on chronic inflammation?

Altered TNFSF4 activity contributes to chronic inflammation.