TNNI3
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Official Full Name
troponin I type 3 (cardiac)
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Overview
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008] -
Synonyms
TNNI3; troponin I type 3 (cardiac); CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF; troponin I, cardiac muscle; cardiomyopathy, dilated 2A (autosomal recessive);
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- HEK293F
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- Human cardiac tissue
- Human Heart
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- Mammalian cells
- Flag
- His
- Fc
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- SUMO
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- DDK
- N
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- Involved Pathway
- Protein Function
- Interacting Protein
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TNNI3 involved in several pathways and played different roles in them. We selected most pathways TNNI3 participated on our site, such as cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNNI3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cAMP signaling pathway | RAF1;NFKBIA;PRKACB;ATP1A1;PRKACG;FSHR;CALML5;GRIN2C;MAPK1 |
| Cardiac muscle contraction | CACNA2D1;UQCR10;ATP1B1B;CACNG2A;ATP1A1;UQCRQ;MYH7;FXYD2;UQCRH |
| Adrenergic signaling in cardiomyocytes | MAPK12A;PRKACAB;PPP2R5D;GNA15.4;ATP1B1B;CALM1A;CACNG7;SCN1BB;ACTC1 |
| Hypertrophic cardiomyopathy (HCM) | ITGA7;DES;ITGAV;LMNA;ATP2A2;ITGB5;ITGA2;CACNB2;PRKAA2 |
| Dilated cardiomyopathy | Adcy4;SGCD;CACNB4;GNAS;MYL3;ITGB1;CACNG6;MYH7;CACNB1 |
TNNI3 has several biochemical functions, for example, actin binding, calcium channel inhibitor activity, calcium-dependent protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNNI3 itself. We selected most functions TNNI3 had, and list some proteins which have the same functions with TNNI3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| actin binding | EMD;CAPZA1;HCLS1;SYNPO2L;MPRIP;LIMCH1A;ACE;DIAPH1;LMOD2 |
| calcium channel inhibitor activity | CCDC109B;PHPT1;PACSIN3;STX1A;SLC30A1A;FKBP1AB;FKBP1B;AMBP;SLC30A1 |
| calcium-dependent protein binding | NRXN1;VLDLR;TNNT3;SYT1;MMP13;S100A4;CPNE3;S100B;SYN1 |
| metal ion binding | LMO7B;PAPD4;MOBKL1A;ADAMTS16;TRIM3B;TRIM35-36;ZNF771;NUDT13;RNF149 |
| protein binding | CLN6;NGB;PIM1;TAL2;ENOX1;SEC61G;SPARC;NDUFAF3;TMEM30B |
| protein domain specific binding | HMGB2;WNT5A;PLG;HOMER3;HIST1H4C;ESRRA;FOXA1;SLC34A2;ARFIP1 |
| protein kinase binding | RAB11FIP2;ATP1A1;MAP2K3;DNM2;ZFP36;VRK1;BORA;USP37;SPDYE2 |
| troponin C binding | TNNT3;TNNI3 |
| troponin T binding | TNNC1;TNNI3;TNNT1;TNNI2 |
TNNI3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNNI3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNNI3.
RCAN3; RCAN3; TNNI3K; PDE4DIP; TNNC1; TNNI3K; TRIM21; TRIM63; SMURF2
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