Recombinant Human TNNI3, His-tagged

• Cat.No.: TNNI3-27665H
• Product Overview: Recombinant Human TNNI3 was expressed as 6*his-tagged fusion protein by E.Coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
• Antigen peptideregion: 1-110aa
• Storagebuffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
• Storage: The protein is stored in PBS buffer at -20 oC. Repeated freezethaw cycles should be avoided.
• OfficialSymbol: TNNI3

Gene Information

• Gene Name: TNNI3 troponin I type 3 (cardiac) [ Homo sapiens ]
• Synonyms: TNNI3; troponin I type 3 (cardiac); CMH7; RCM1; cTnI; CMD2A; TNNC1; MGC116817; CMD1FF; troponin I, cardiac; Troponin I, cardiac muscle; Cardiac troponin I; familial hypertrophic cardiomyopathy 7
• Gene ID: 7137
• mRNA Refseq: NM_000363
• Protein Refseq: NP_000354
• MIM: 191044
• UniProt ID: P19429
• Chromosome Location: 19q13.4
• Pathway: Hypertrophic cardiomyopathy (HCM); Muscle contraction; Cardiac muscle contraction
• Function: actin binding; calcium-dependent protein binding; protein domain specific binding; protein kinase binding; troponin C binding; troponin T binding; calcium channel inhibitor activity