Recombinant Full Length Human TNNI3 Protein, C-Flag-tagged
Cat.No. : | TNNI3-809HFL |
Product Overview : | Recombinant Full Length Human TNNI3 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
- Specification
- Gene Information
- Related Products
Description : | Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 23.8 kDa |
AA Sequence : | MADGSSDAAREPRPAPAPIRRRSSN YRAYATEPHAKKKSKISASRKLQLK TLLLQIAKQELEREAEERRG EKGRALSTRCQPLELAGLGFAELQD LCRQLHARVDKVDEERYDIEAKVTK NITEIADLTQKIFDLRGKFK RPTLRRVRISADAMMQALLGARAKE SLDLRAHLKQVKKEDTEKENREVGD WRKNIDALSGMEGRKKKFESTRTRP LEQKLISEEDLAANDILDYKDDDDK V |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Druggable Genome, ES Cell Differentiation/IPS, Stem cell - Pluripotency |
Protein Pathways : | Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM) |
Gene Name : | TNNI3 troponin I3, cardiac type [ Homo sapiens (human) ] |
Official Symbol : | TNNI3 |
Synonyms : | CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF |
Gene ID : | 7137 |
mRNA Refseq : | NM_000363.5 |
Protein Refseq : | NP_000354.4 |
MIM : | 191044 |
UniProt ID : | P19429 |
Products Types
◆ Recombinant Protein | ||
TNNI3-2254H | Recombinant Human TNNI3 Protein, MYC/DDK-tagged | +Inquiry |
Tnni3-6569M | Recombinant Mouse Tnni3 Protein, Myc/DDK-tagged | +Inquiry |
TNNI3-2683H | Recombinant Human TNNI3 protein(11-130 aa), N-SUMO & N-His-tagged | +Inquiry |
TNNI3-0060H | Recombinant Human TNNI3 Protein | +Inquiry |
TNNI3-008H | Recombinant Human TNNI3 Protein | +Inquiry |
◆ Native Protein | ||
TNNI3-223H | Native Human Troponin I Type 3 (Cardiac) | +Inquiry |
Tnni3-7423M | Native Mouse Tnni3 Protein | +Inquiry |
TNNI3-01H | Native Human TNNI3 Protein | +Inquiry |
◆ Lysates | ||
TNNI3-1803HCL | Recombinant Human TNNI3 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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