Active Recombinant Human CCL20 Protein (70 aa)
Cat.No. : | CCL20-327C |
Product Overview : | Recombinant Human MIP-3α/CCL20 produced in E. coliis a single non-glycosylated polypeptide chain containing 70 amino acids. A fully biologically active molecule, rhMIP-3α/CCL20has a molecular mass of 8.0 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques. |
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Description : | Chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family. It is strongly chemotactic for lymphocytes and weakly attracts neutrophils, also known as LARC (Liver and Activation-regulated Chemokine) and as Exodus. It can signal through the CCR6 receptor. MIP-3 alpha is chemotactic towards lymphocytes and dendritic cells. Additionally, it promotes the adhesion of memory CD4+ T cells and inhibits colony formation of bone marrow myeloid immature progenitors. |
Source : | E. coli |
Species : | Human |
Form : | Sterile Filtered White lyophilized (freeze-dried) powder. |
Bio-activity : | The EC50 value of humanMIP-3 alpha/CCL20 on Ca^2+ mobilization assay in CHO-K1/Gα15/hCCR6 cells (human Gα15 and human CCR6 stably expressed in CHO-K1 cells) is less than 200 ng/mL. |
Molecular Mass : | 8.0 kDa, observed by reducing SDS-PAGE. |
Protein Length : | 70 |
AA Sequence : | ASNFDCCLGYTDRILHPKFIVGFTR QLANEGCDINAIIFHTKKKLSVCAN PKQTWVKYIVRLLSKKVKNM |
Endotoxin : | < 0.2 EU/μg, determined by LAL method. |
Purity : | > 95% as analyzed by SDS-PAGE. |
Storage : | Lyophilized recombinant Human MIP- 3α/CCL20 remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, recombinant human MIP-3α/CCL20 should be stable up to 1 week at 4 centigrade or up to 2 months at -20 centigrade. |
Storage Buffer : | Lyophilized after extensive dialysis against 53mM Na2HPO4, 147 mM NaH2PO4, 300 mM NaCl, pH6.5. |
Reconstitution : | Reconstituted in ddH2O or PBS at 100 μg/mL. |
Gene Name : | CCL20 chemokine (C-C motif) ligand 20 [ Homo sapiens ] |
Official Symbol : | CCL20 |
Synonyms : | CCL20; chemokine (C-C motif) ligand 20; SCYA20, small inducible cytokine subfamily A (Cys Cys), member 20; C-C motif chemokine 20; CKb4; exodus 1; LARC; MIP 3a; ST38; exodus-1; MIP-3-alpha; CC chemokine LARC; beta chemokine exodus-1; beta-chemokine exodus-1; small-inducible cytokine A20; macrophage inflammatory protein 3 alpha; liver and activation-regulated chemokine; small inducible cytokine subfamily A (Cys-Cys), member 20; MIP3A; MIP-3a; SCYA20; |
Gene ID : | 6364 |
mRNA Refseq : | NM_001130046 |
Protein Refseq : | NP_001123518 |
MIM : | 601960 |
UniProt ID : | P78556 |
Products Types
◆ Recombinant Protein | ||
CCL20-17H | Recombinant Human CCL20 Protein | +Inquiry |
CCL20-641H | Recombinant Human CCL20 Protein, GST-tagged | +Inquiry |
CCL20-870R | Recombinant Rat CCL20 Protein, His (Fc)-Avi-tagged | +Inquiry |
CCL20-073C | Active Recombinant Human CCL20 Protein (70 aa) | +Inquiry |
CCL20-1082B | Recombinant Bovine CCL20 Protein (27-96 aa), His-SUMO-tagged | +Inquiry |
◆ Lysates | ||
CCL20-447MCL | Recombinant Mouse CCL20 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Write a reviewExpert protein engineering support, essential for our projects' progress.
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Q&As (7)
Ask a questionCCL20 influences dendritic cell migration and differentiation, crucial for initiating immune responses.
CCL20 contributes to cancer progression by shaping the tumor microenvironment and aiding tumor cell invasion.
CCL20 plays a significant role in autoimmune diseases by attracting inflammatory cells to affected joints.
CCL20 is involved in wound healing and tissue repair, facilitating immune cell migration and tissue regeneration.
Changes in CCL20 expression impact skin health, potentially contributing to the development of skin disorders.
CCL20 recruits and activates immune cells to sites of inflammation, coordinating the immune response.
CCL20 impacts mucosal immunity, playing a critical role in immune defense in the gut and respiratory system.
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