Active Recombinant Human IL11 Protein
|Product Overview :||The mature recombinant human IL-11 protein consists of 179 amino acids (19-178) without tag was expressed in E. coli.|
- Gene Information
- Related Products
|Description :||The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.|
|Source :||E. coli|
|Bio-activity :||Measured in a cell proliferation assay using T11 mouse plasmacytoma cells. The ED50 for this effect is 0.02-0.12 ng/mL.|
|Molecular Mass :||19.3 kDa|
|Product-Related Proteins :||19-178|
|Endotoxin :||< 1.0 EU/μg of the protein as determined by the LAL method|
|Purity :||> 95 % as determined by SDS-PAGE|
|Storage :||At -80 centigrade. Avoid repeated freeze-thaw cycles.|
|Storage Buffer :||PBS|
|Gene Name :||IL11 interleukin 11 [ Homo sapiens (human) ]|
|Official Symbol :||IL11|
|Synonyms :||IL11; interleukin 11; AGIF; IL-11; interleukin-11; adipogenesis inhibitory factor; oprelvekin|
|Gene ID :||3589|
|mRNA Refseq :||NM_000641|
|Protein Refseq :||NP_000632|
|UniProt ID :||P20809|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
Transgenic mice and knockdown models explore IL11's impact on tissue regeneration.
Site-directed mutagenesis identifies key residues in IL11's interaction with IL11RA.
Chromatin immunoprecipitation and DNA methylation analysis decipher IL11's regulatory mechanisms.
Proteomics identifies IL11-interacting proteins and potential cross-talk partners.
Cell-based and luciferase reporter assays elucidate IL11's JAK-STAT signaling activation.
RNA sequencing uncovers IL11-induced gene expression changes across different cell types.
X-ray crystallography and NMR spectroscopy reveal structural details of the IL11-IL11RA complex.
Confocal and super-resolution microscopy visualize IL11 localization in tissues.
Techniques like surface plasmon resonance measure IL11-IL11RA binding affinity and kinetics.
CRISPR screening unveils genes and pathways influenced by IL11 signaling.
Customer Reviews (3)Write a review
Potent in bone regeneration models. -
Suitable for cell culture. -
High yield in expression. -
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