Active Recombinant Human IL11 Protein

• Cat.No.: IL11-953H
• Product Overview: Recombinant Human IL11(Pro22-Leu199) was expressed in Pichia Pastoris.

Specification

• Description: The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
• Source: Pichia Pastoris
• Form: Lyophilized from a 0.2 µM filtered solution of 20mM Phosphate buffer, 2% Glycine, pH 7.2. Stable for at least 6 months from date of receipt under proper storage and handling conditions.
• Bio-activity: ED50 is less than 0.2 ng/ml as determined by the dose-dependent stimulation of murine 7TD1 proliferation. Specific Activity of 8.0 x 10⁶ IU/ mg.
• Molecular Mass: 19.1 kDa
• Endotoxin: < 0.1 EU per µg protein as determined by LAL test
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: Resuspend the protein to the desired concentration in proper buffer.

Gene Information

• Gene Name: IL11 interleukin 11 [ Homo sapiens ]
• Official Symbol: IL11
• Synonyms: IL11; interleukin 11; interleukin-11; adipogenesis inhibitory factor; AGIF; IL 11; oprelvekin; IL-11
• Gene ID: 3589
• mRNA Refseq: NM_000641
• Protein Refseq: NP_000632
• MIM: 147681
• UniProt ID: P20809