Active Recombinant Human IL27, Fc-tagged
|Product Overview :||The human IL-27 complex composed of the Ebi3 subunit (aa 21-229) and the p28 subunit (aa 26-243) is fused through a polypeptide linker to the Fc portion of a mutant human IgG1.|
- Gene Information
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|Description :||Interleukin-27 (IL-27) is a heterodimeric group 2 receptor ligand molecule that belongs to the IL-6/IL-12 family of long type I cytokines. It is composed of EBI3 (EBV-induced gene 3), a 34 kDa glycoprotein that is related to the p40 subunit of IL-12 and IL-23, and p28, the cloned 28 kDa glycoprotein that is related to the p35 chain of IL-12. IL-27 is expressed by monocytes, endothelial cells and dendritic cells. IL-27 binds to and signals through a heterodimeric receptor complex composed of WSX1 (TCCR) and gp130. Evidence suggests IL-27 interacts only with WSX-1. IL-27 has both anti- and proinflammatory properties. As an antiinflammatory, IL-27 seems to induce a general negative feedback program that limits T and NK-T cell activity. At the onset of infection, IL-27 induces an IL-12 receptor on na?e CD4+ T cells, making them susceptible to subsequent IL-12 activity (and possible Th1 development). Notably, IL-12 family cytokines are both induced and inhibited by bacterial products. Microbes promote IL-27 secretion through TLR4, and also block IL-27 production via C5a induction.|
|Source :||CHO Cells|
|Form :||Lyophilized from 0.2μm-filtered solution in PBS.|
|Bio-activity :||Bioactivity was measured in a cell proliferation assay using anti-CD3 activated human peripheral mononuclear cells.|
|Purity :||≥98% (SDS-PAGE)|
|Stability :||Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.|
|Storage :||Short Term Storage: +4°C; Long Term Storage: -20°C. Avoid freeze/thaw cycles.|
|Gene Name :||IL27 interleukin 27 [ Homo sapiens ]|
|Official Symbol :||IL27|
|Synonyms :||IL27; interleukin 27;|
|Gene ID :||144841|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
The current challenges in the study of Il27 include potential side effects, preparation purity and other challenges.
The potential application of Il27 in tumor immunotherapy and autoimmune diseases is being deeply studied in the scientific research field.
The production of Il27 is related to genetic factors, and the expression level and polymorphism of genes may affect its production and function.
Studies have shown that Il27 may have an anti-inflammatory effect in inflammatory diseases, regulating the degree of inflammatory response.
Current studies have shown that Il27 has potential application value in enhancing anti-tumor immunity and alleviating tumor invasion and metastasis.
Il27 can enhance the activation and proliferation of specific immune cells and regulate the intensity and direction of immune response.
Customer Reviews (3)Write a review
The purity is very high, no impurities. -
Biological activity is very strong and can be used in various biological experiments. -
Stability is very good, and it will not denaturate at high temperatures. -
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