Active Recombinant Human IL27, Fc-tagged
Cat.No. : | IL27-349H |
Product Overview : | The human IL-27 complex composed of the Ebi3 subunit (aa 21-229) and the p28 subunit (aa 26-243) is fused through a polypeptide linker to the Fc portion of a mutant human IgG1. |
- Specification
- Gene Information
- Related Products
Description : | Interleukin-27 (IL-27) is a heterodimeric group 2 receptor ligand molecule that belongs to the IL-6/IL-12 family of long type I cytokines. It is composed of EBI3 (EBV-induced gene 3), a 34 kDa glycoprotein that is related to the p40 subunit of IL-12 and IL-23, and p28, the cloned 28 kDa glycoprotein that is related to the p35 chain of IL-12. IL-27 is expressed by monocytes, endothelial cells and dendritic cells. IL-27 binds to and signals through a heterodimeric receptor complex composed of WSX1 (TCCR) and gp130. Evidence suggests IL-27 interacts only with WSX-1. IL-27 has both anti- and proinflammatory properties. As an antiinflammatory, IL-27 seems to induce a general negative feedback program that limits T and NK-T cell activity. At the onset of infection, IL-27 induces an IL-12 receptor on na?e CD4+ T cells, making them susceptible to subsequent IL-12 activity (and possible Th1 development). Notably, IL-12 family cytokines are both induced and inhibited by bacterial products. Microbes promote IL-27 secretion through TLR4, and also block IL-27 production via C5a induction. |
Source : | CHO Cells |
Species : | Human |
Tag : | Fc |
Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
Bio-activity : | Bioactivity was measured in a cell proliferation assay using anti-CD3 activated human peripheral mononuclear cells. |
Purity : | ≥98% (SDS-PAGE) |
Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Storage : | Short Term Storage: +4°C; Long Term Storage: -20°C. Avoid freeze/thaw cycles. |
Gene Name : | IL27 interleukin 27 [ Homo sapiens ] |
Official Symbol : | IL27 |
Synonyms : | IL27; interleukin 27; |
Gene ID : | 144841 |
Products Types
◆ Recombinant Protein | ||
Il27-2307M | Recombinant Mouse Il27 Protein, His-tagged | +Inquiry |
Il27-185M | Recombinant Active Mouse IL27 Protein, His-tagged(C-ter) | +Inquiry |
IL27-2306H | Recombinant Human IL27 Protein, His-tagged | +Inquiry |
IL27-1033H | Recombinant Human IL27 Protein, His-tagged | +Inquiry |
Il27-3518M | Active Recombinant Mouse Il27 Protein | +Inquiry |
◆ Lysates | ||
IL27-1309MCL | Recombinant Mouse IL27 cell lysate | +Inquiry |
IL27-001HCL | Recombinant Human IL27 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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