Active Recombinant Human IL34 Protein (Asn21-Pro242), C-His tagged, Animal-free, Carrier-free

Cat.No. : IL34-31H
Product Overview : Recombinant Human IL34 Protein (Asn21-Pro242) with C-His tag was expressed in E. coli and Animal-free as well as Carrier-free.
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Description : Interleukin-34 (IL-34) is a 30 kDa cytokine with 223 amino acid residues. IL-34 is a ligand of CSF-1R and secreted from CSF-1R expressing cells like myeloid cells, epithelial cells, endothelial cells, fibroblasts, and neurons. IL-34 mediates cell survival, proliferation, cytokine/chemokine expression, and migration via activating several signaling pathways. Moreover, it also plays a critical role in developing and maintaining the mononuclear phagocytic system.
Source : E. coli
Species : Human
Tag : His
Form : Lyophilized
Bio-activity : Measure by its ability to induce human peripheral blood monocytes (PBMCs) proliferation. The ED50 for this effect is < 30 pg/mL.
Molecular Mass : The protein has a calculated MW of 26.17 kDa.
The protein migrates as 30 kDa under reducing condition (SDS-PAGE analysis).
Protein Length : Asn21-Pro242
Endotoxin : < 0.1 EU/μg of the protein by the LAL method.
Purity : >98% as determined by SDS-PAGE analysis.
Storage : This product is stable after storage at:
-20 centigrade for 12 months in lyophilized state from date of receipt.
-20 or -80 centigrade for 1 month under sterile conditions after reconstitution.
Avoid repeated freeze/thaw cycles.
Storage Buffer : Lyophilized from a 0.2 μm filtered solution of PBS, pH 8.0.
Reconstitution : It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.
Shipping : The product is shipped with polar packs. Upon receipt, store it immediately at -20 centigrade or lower for long term storage.
Gene Name : IL34 interleukin 34 [ Homo sapiens (human) ]
Official Symbol : IL34
Synonyms : IL34; interleukin 34; C16orf77, chromosome 16 open reading frame 77; interleukin-34; IL 34; MGC34647; IL-34; C16orf77;
Gene ID : 146433
mRNA Refseq : NM_001172771
Protein Refseq : NP_001166242
MIM : 612081
UniProt ID : Q6ZMJ4

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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Customer Reviews (3)

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    IL34 has shown good biocompatibility and safety in related experiments.


      When using IL34 for experiments, the experimental conditions and results are highly repeatable.


        Quality is stable and reliable, with no significant differences between batches.

        Q&As (6)

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        What is the effect of IL34 on tumor prognosis? 09/19/2022

        There are no clear studies showing the effect of IL34 on tumor prognosis.

        What are the advantages of IL34 over other treatments? 05/14/2022

        Can fight disease by modulating the immune system and may have better efficacy and fewer side effects than other treatments.

        What is the mechanism of action of IL34 in the treatment of tumor? 07/09/2020

        May inhibit tumor growth and metastasis by enhancing immune cells' ability to attack tumor cells.

        How is the clinical trial of IL34 progressing? 04/02/2020

        No large-scale clinical trials have been reported, but some early studies have shown a potential therapeutic effect.

        How does IL34 affect the immune system? 03/26/2020

        Regulate the function of macrophages and dendritic cells and affect the immune response of the immune system.

        How to evaluate the efficacy of IL34? 01/31/2019

        The evaluation of the efficacy of IL34 usually requires a comprehensive evaluation of clinical symptoms, biochemical indicators, imaging and other indicators.

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