Recombinant Human IL34 Protein, His-tagged

• Cat.No.: IL34-001H
• Product Overview: Recombinant human IL34 (21-242aa), fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Specification

• Description: IL34, also known as interleukin-34 isoform 1, is a secreted cytokine. This protein is expressed in a variety of tissues richest in the spleen and stimulates the proliferation of monocytes. In a functional study, IL-34, such as CSF-1, another ligand for CSF-1R, stimulated phosphorylation of extracellular signal-regulated kinase-1 and -2 (ERK1 / 2) in human monocytes. In addition, it promoted the formation of macrophage precursor colonization units-macrophages (CFU-M) in human bone marrow cultures.
• Source: Insect cell
• Species: Human
• Tag: His
• Form: Liquid
• Molecular Mass: 26.3 kDa
• AASequence: ADPNEPLEMWPLTQNEECTVTGFLR DKLQYRSRLQYMKHYFPINYKISVP YEGVFRIANVTRLQRAQVSERELRY LWVLVSLSATESVQDVLLEGHPSWK YLQEVQTLLLNVQQGLTDVEVSPKV ESVLSLLNAPGPNLKLVRPKALLDN CFRVMELLYCSCCKQSSVLNWQDCE VPSPQSCSPEPSLQYAATQLYPPPP WSPSSPPHSTGSVRPVRAQGEGLLP HHHHHH
• N-terminal Sequence Analysis: Ala
• Endotoxin: < 1.0 EU per 1 μg of protein (determined by LAL method)
• Purity: > 90% by SDS - PAGE
• Storage: Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 0.25 mg/mL (determined by Absorbance at 280nm)
• Storage Buffer: In 20mM Tris-Hcl buffer (pH 8.5) containing 1mM DTT, 0.15M NaCl, 01mM PMSF, 1mM EDTA, 30% glycerol.
• Warning: For research use only. This product is not intended or approved for human, diagnostics or veterin
• Protein length: 21-242

Gene Information

• Gene Name: IL34 interleukin 34 [ Homo sapiens (human) ]
• Official Symbol: IL34
• Synonyms: IL34; interleukin 34; IL-34; C16orf77; interleukin-34
• Gene ID: 146433
• mRNA Refseq: NM_152456
• Protein Refseq: NP_689669
• MIM: 612081
• UniProt ID: Q6ZMJ4

Reviews

05/10/2021

IL34 has shown good biocompatibility and safety in related experiments.

01/19/2020

When using IL34 for experiments, the experimental conditions and results are highly repeatable.

10/24/2019

Quality is stable and reliable, with no significant differences between batches.

Q&As

What is the effect of IL34 on tumor prognosis?

There are no clear studies showing the effect of IL34 on tumor prognosis.

What are the advantages of IL34 over other treatments?

Can fight disease by modulating the immune system and may have better efficacy and fewer side effects than other treatments.

What is the mechanism of action of IL34 in the treatment of tumor?

May inhibit tumor growth and metastasis by enhancing immune cells' ability to attack tumor cells.

How is the clinical trial of IL34 progressing?

No large-scale clinical trials have been reported, but some early studies have shown a potential therapeutic effect.

How does IL34 affect the immune system?

Regulate the function of macrophages and dendritic cells and affect the immune response of the immune system.

How to evaluate the efficacy of IL34?

The evaluation of the efficacy of IL34 usually requires a comprehensive evaluation of clinical symptoms, biochemical indicators, imaging and other indicators.