Active Recombinant Mouse Il34 Protein, His-tagged
|Product Overview :||Purified recombinant protein of Mouse interleukin 34 (Il34), transcript variant 1 with a C-His tag was expressed in CHO.|
- Gene Information
- Related Products
|Description :||Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.|
|Bio-activity :||The ED50 is 20 - 30 ng/mL, corresponding to a specific activity of 3.3 - 5 × 10^4 units/mg, determined by M-NFS-60 cell proliferation induction in a dose dependent manner.|
|Molecular Mass :||26 kDa|
|Protein length :||Met1- Pro235|
|Endotoxin :||Less than 0.01 ng/μg protein as determined by the LAL method|
|Purity :||> 98%, as determined by Coomassie stained SDS-PAGE.|
|Stability :||Unopened vial can be stored between 2 and 8 centigrade for up to 2 weeks, at -20 centigrade for up to 6 months, or at -70 centigrade or below until the expiration date. Aliquots can be stored between 2 and 8 centigrade for up to one week and stored at -20 centigrade or colder for up to 3 months. Avoid repeated freeze/thaw cycles.|
|Storage :||Store at -80 centigrade.|
|Concentration :||Protein formulated and vialed at >50 μg/mL in specified buffer|
|Storage Buffer :||10 mM NaH2PO4, 0.5 M NaCl, pH 7.4|
|Gene Name :||Il34 interleukin 34 [ Mus musculus (house mouse) ]|
|Official Symbol :||Il34|
|Synonyms :||IL34; interleukin 34; interleukin-34; IL-34; AI593503; 2010004A03Rik|
|Gene ID :||76527|
|mRNA Refseq :||NM_001135100|
|Protein Refseq :||NP_001128572|
|UniProt ID :||Q8R1R4|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
There are no clear studies showing the effect of IL34 on tumor prognosis.
Can fight disease by modulating the immune system and may have better efficacy and fewer side effects than other treatments.
May inhibit tumor growth and metastasis by enhancing immune cells' ability to attack tumor cells.
No large-scale clinical trials have been reported, but some early studies have shown a potential therapeutic effect.
Regulate the function of macrophages and dendritic cells and affect the immune response of the immune system.
The evaluation of the efficacy of IL34 usually requires a comprehensive evaluation of clinical symptoms, biochemical indicators, imaging and other indicators.
Customer Reviews (3)Write a review
IL34 has shown good biocompatibility and safety in related experiments. -
When using IL34 for experiments, the experimental conditions and results are highly repeatable. -
Quality is stable and reliable, with no significant differences between batches. -
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