Rabbit Anti-Mouse Cathepsin D Monoclonal Antibody


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Rabbit Anti-Mouse Cathepsin D Monoclonal Antibody

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Cat.No. : CAB11522RM
Product Overview : Rabbit Monoclonal Antibody to Mouse Cathepsin D
Antigen Description : Cathepsin D (CTSD) is a well known lysosomal aspartyl protease and is a member of the peptidase C1 family found in almost all cells and tissues of mammals. It has a specificity similar to but narrower than that of pepsin A. Cathepsin D plays an important role in the degradation of proteins, the generation of bioactive proteins, antigen processing, etc. Cathepsin D is an important regulator of apoptotic pathways in cells. It acts at different stage of intrinsic and extrinsic pathway of apoptosis, and can also induce apoptosis in presence of cytotoxic factors. However, on contrast, in certain studies an inhibitory role of CTSD in apoptosis was also reviewed. In addition, CTSD secreted from human prostate carcinoma cells are responsible for the generation of angiostatin, a potent endogenous inhibitor of angiogenesis, suggesting its contribution to the prevention of tumor growth and angiogenesis-dependent growth of metastases.
Specificity : Mouse Cathepsin D / CTSD. No cross-reactivity with human cell lysate ( 293 cell line ) in WB and ELISA.
Immunogen : Recombinant Mouse Cathepsin D / CTSD Protein
Host : Rabbit
Isotype : Rabbit IgG
Species : Mouse
Clone : A103
Applications : WB; ELISA
Dilution : Western blot: This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Mouse CTSD in WB. Using a DAB detection system, the detection limit for Mouse CTSD is approximately 1 ng/lane under non-reducing conditions and 0.5 ng/lane under reducing conditions.ELISA: This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse CTSD. The detection limit for Mouse CTSD is approximately 0.00975 ng/well.
Preparation : This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant Mouse Cathepsin D / CTSD
Format : 0.2 μm filtered solution in PBS with 5% trehalose
Storage : This antibody can be stored at 2-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 to -70°C. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Gene Name : Ctsd cathepsin D [ Mus musculus ]
Official Symbol : Ctsd
Synonyms : CTSD; cathepsin D; CD; CatD;
Gene ID : 13033
mRNA Refseq : NM_009983
Protein Refseq : NP_034113
Pathway : Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; Tuberculosis, organism-specific biosystem; Tuberculosis, conserved biosystem;
Function : aspartic-type endopeptidase activity; endopeptidase activity; hydrolase activity; peptidase activity; peptide binding;

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