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Recombinant Human SRC, GST-tagged

Cat. No.: SRC-191H
Description: Src (p60c-src) is a 60 kDa cytoplasmic tyrosine kinase with functions in the regulation of cell division, cell-matrix adhesion, and cell-cellcell adhesion. Src-GST family tyrosine kinases participate in signal transduction of different classes of membrane receptors, including receptor tyrosine kinases and G-protein coupeled receptors. The SrcGST has been generated by fusing GST N-terminal to human c-Src allowing expression inE. coliand purification by affinity chromatography with GSHbeads. The preparation is >90% homogenous in SDS-PAGE and has a specific activity of >3000 U/mg (1 U is defined as transfer of 1 pMol phosphate to the substrate peptide AAEEEIYGEFEAKKKK per minute at 30°C). The fusion protein has been successfully used to label phosphatase substrates. The GST-Tag facilitates the protein's application in typical GST pull-down assays.
Source: E. coli.
Form: Liquid. Supplied in 50 mM Tris-HCl pH 8.0, 100 mM NaCl and 1 mM DTT.
Purity: ≥90% by SDS-PAGE.
Application: > 650 U/µg (1 U is defined as transfer of 1 pMol phosphate to the substrate peptide AAEEEIYG-EFEAKKKK per minute at 30°C).
Usage: For in vitro use only.
Storage: Quality guaranteed for 12 months store at -80°C. Avoid freeze / thaw cycles.
Gene Name: SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [ Homo sapiens ]
Synonyms: SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); ASV; SRC1; c-SRC; p60-Src; proto-oncogene tyrosine-protein kinase SRC; OTTHUMP00000174476; OTTHUMP00000174477; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; protooncogene SRC, Rous sarcoma; EC 2.7.10.2; pp60c-src; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogenehomolog
Gene ID: 6714
mRNA Refseq: NM_005417
Protein Refseq: NP_005408
MIM: 190090
UniProt ID: P12931
Chromosome Location: 20q12-q13
Pathway: Adherens junction; Endocytosis; Epithelial cell signaling in Helicobacter pylori infection; ErbB signaling pathway; Focal adhesion; Gap junction; GnRH signaling pathway; Tight junction; VEGF signaling pathway
Function: ATP binding; SH2 domain binding; SH3/SH2 adaptor activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; transferase activity

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