Recombinant Human v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) Protein, His-tagged
Cat.No. : | SRC-001H |
Product Overview : | Recombinant Human SRC Protein (1-79aa) with C-His-tag was expressed in E. coli. |
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Description : | This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. |
Source : | E. coli |
Species : | Human |
Tag : | C-His |
Protein length : | 1-79aa |
Molecular Mass : | 9 kDa |
AA Sequence : | MGSNKSKPKDASQRRRSLEPAENVH GAGGGAFPASQTPSKPASADGHRGP SAAFAPAAAEPKLFGGFNSSDTVTS PQRAHHHHHHHH |
Endotoxin : | < 1 EU/μg by LAL. |
Purity : | > 90 % by SDS-PAGE |
Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Concentration : | 1 mg/mL by BCA |
Storage Buffer : | Sterile PBS, pH7.4 |
Gene Name : | SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [Homo sapiens (human)] |
Official Symbol : | SRC |
Synonyms : | SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); SRC1, v src avian sarcoma (Schmidt Ruppin A 2) viral oncogene homolog; proto-oncogene tyrosine-protein kinase Src; ASV; c src; proto-oncogene c-Src; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; protooncogene SRC, Rous sarcoma; SRC1; c-SRC; p60-Src |
Gene ID : | 6714 |
mRNA Refseq : | NM_005417 |
Protein Refseq : | NP_005408 |
MIM : | 190090 |
UniProt ID : | P12931 |
Products Types
◆ Native Protein | ||
SRC-29697TH | Native Human SRC | +Inquiry |
◆ Lysates | ||
SRC-487HCL | Recombinant Human SRC cell lysate | +Inquiry |
SRC-585MCL | Recombinant Mouse SRC cell lysate | +Inquiry |
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Q&As (7)
Ask a questionChanges in SRC expression or kinase activity can lead to drug resistance in cancer treatment.
SRC regulates cell proliferation and survival through its kinase activity, influencing various signaling pathways.
SRC is involved in bone remodeling, regulating osteoclast activity and bone resorption.
SRC plays a crucial role in cancer progression, particularly in enhancing metastatic potential of tumor cells.
SRC influences key cellular signaling pathways like Ras/MAPK and PI3K/Akt, affecting cell growth and survival.
SRC modulates cellular adhesion and migration, playing a role in tissue repair and cancer metastasis.
SRC inhibition is a target in cancer therapy, potentially reducing tumor growth and metastasis.
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