Native Human APOC2

• Cat.No.: APOC2-27332TH
• Product Overview: Full length Human Apolipoprotein CII mature protein purified from Human Plasma, Very Low Density Lipoprotein.

Specification

• Description: This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene.
• Form: Lyophilised:Reconstitute with 32.7ul distilled water.
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10mM Ammonium bicarbonate, pH 7.4
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

Gene Information

• Gene Name: APOC2 apolipoprotein C-II [ Homo sapiens ]
• Official Symbol: APOC2
• Synonyms: APOC2; apolipoprotein C-II
• Gene ID: 344
• mRNA Refseq: NM_000483
• Protein Refseq: NP_000474
• MIM: 608083
• Uniprot ID: P02655
• Chromosome Location: 19q13.2
• Pathway: Chylomicron-mediated lipid transport, organism-specific biosystem; HDL-mediated lipid transport, organism-specific biosystem; Lipid digestion, mobilization, and transport, organism-specific biosystem; Lipoprotein metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem
• Function: enzyme activator activity; lipase inhibitor activity; lipid binding; lipoprotein lipase activator activity; phospholipase activator activity