Native Human APOC2

Cat.No. : APOC2-27332TH
Product Overview : Full length Human Apolipoprotein CII mature protein purified from Human Plasma, Very Low Density Lipoprotein.
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  • Gene Information
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Description : This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene.
Form : Lyophilised:Reconstitute with 32.7ul distilled water.
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 10mM Ammonium bicarbonate, pH 7.4
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Gene Name : APOC2 apolipoprotein C-II [ Homo sapiens ]
Official Symbol : APOC2
Synonyms : APOC2; apolipoprotein C-II;
Gene ID : 344
mRNA Refseq : NM_000483
Protein Refseq : NP_000474
MIM : 608083
Uniprot ID : P02655
Chromosome Location : 19q13.2
Pathway : Chylomicron-mediated lipid transport, organism-specific biosystem; HDL-mediated lipid transport, organism-specific biosystem; Lipid digestion, mobilization, and transport, organism-specific biosystem; Lipoprotein metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem;
Function : enzyme activator activity; lipase inhibitor activity; lipid binding; lipoprotein lipase activator activity; phospholipase activator activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (24)

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What happens in the absence of functional APOC2 protein? 04/16/2023

Without functional APOC2 protein, the activation of lipoprotein lipase is compromised, leading to elevated levels of triglycerides in the blood, a condition known as hypertriglyceridemia.

Can lifestyle modifications, such as exercise, impact APOC2 protein levels or function? 11/26/2022

Regular exercise has been shown to improve lipid metabolism and positively affect APOC2 protein activity, resulting in lower triglyceride levels in the blood.

Are there any disorders or diseases associated with abnormalities in APOC2 protein? 10/18/2022

Yes, mutations or deficiencies in the APOC2 gene can lead to various lipid metabolism disorders, including familial hypercholesterolemia and familial chylomicronemia syndrome.

Can variations or mutations in the APOC2 gene affect its protein function? 09/30/2022

Yes, variations or mutations in the APOC2 gene can affect the structure or function of the APOC2 protein, leading to altered lipid metabolism and potentially causing lipid-related disorders.

Are there any dietary factors that influence APOC2 protein and its function? 09/04/2022

High-fat diets and excessive consumption of saturated fats are known to influence APOC2 protein activity and triglyceride levels in the body.

Can APOC2 protein be targeted for therapeutic interventions? 05/24/2022

Yes, targeting APOC2 protein has been explored as a potential therapeutic strategy for the treatment of hypertriglyceridemia and related disorders. Inhibitors or modulators of APOC2 protein activity are currently under investigation.

Are there any known natural compounds or supplements that can influence APOC2 protein function? 03/28/2022

Some natural compounds, such as omega-3 fatty acids and polyphenols found in certain foods, have been reported to modulate APOC2 protein activity and lipid metabolism. However, more research is required to fully understand their effects and establish appropriate dosage recommendations.

Are there any known drugs or medications that target APOC2 protein? 12/10/2021

Currently, there are no medications specifically approved for targeting APOC2 protein. However, certain lipid-lowering medications, such as fibrates and omega-3 fatty acid supplements, indirectly affect APOC2 protein activity by modulating lipid metabolism.

Can APOC2 protein levels be measured in the blood? 09/29/2020

Yes, APOC2 protein levels can be measured in blood samples using immunoassays.

Are there any genetic tests available to screen for APOC2 gene mutations? 03/13/2020

Yes, genetic tests can be used to screen for mutations in the APOC2 gene, particularly in individuals with a family history of lipid metabolism disorders. These tests can help identify individuals at risk and guide treatment options.

Is there ongoing research on APOC2 and its potential therapeutic applications? 02/06/2020

Yes, researchers are studying the role of APOC2 in lipid metabolism disorders and exploring potential therapeutic strategies targeting this protein. Additionally, some studies are investigating the use of APOC2-modulating therapies for the treatment of hypertriglyceridemia.

Can APOC2 protein levels be used as a biomarker for cardiovascular diseases? 09/05/2019

APOC2 protein levels have been associated with increased risk of cardiovascular diseases, particularly hypertriglyceridemia-associated conditions. However, further research is needed to establish its utility as a reliable biomarker.

Does the APOC2 protein have any other biological functions apart from lipid metabolism? 08/31/2019

Apart from its role in lipid metabolism, the APOC2 protein has been implicated in inflammation, immune response, and cell proliferation processes, although further research is needed to fully understand these functions.

What are the potential side effects of APOC2-targeting therapies or interventions? 07/15/2019

The potential side effects of APOC2-targeting therapies or interventions may vary depending on the specific treatment approach. However, some common side effects associated with lipid-lowering medications or interventions include gastrointestinal issues, muscle pain, liver problems, and allergic reactions. It is essential to consult with a healthcare professional for personalized information and guidance.

Are there any genetic disorders associated with APOC2 protein? 07/19/2018

Yes, there are rare genetic disorders associated with APOC2 protein, such as familial chylomicronemia syndrome (FCS) and lipoprotein lipase deficiency (LPLD), which result in severe hypertriglyceridemia.

Is the APOC2 protein targeted by any current medications? 07/09/2018

Yes, some medications, such as fibrates and omega-3 fatty acids, can help regulate APOC2 protein activity and reduce triglyceride levels in individuals with hypertriglyceridemia.

Is there any relationship between APOC2 protein and obesity? 05/02/2018

Studies have suggested a potential association between APOC2 protein and obesity, as higher levels of APOC2 have been observed in individuals with obesity, contributing to elevated triglyceride levels.

Is there any association between APOC2 protein and cardiovascular diseases? 12/18/2017

Elevated levels of triglycerides, caused by dysfunction of APOC2 protein, have been associated with an increased risk of cardiovascular diseases such as coronary artery disease and atherosclerosis.

Can APOC2 gene therapy be a potential treatment approach for lipid metabolism disorders? 11/05/2017

APOC2 gene therapy is being explored as a potential treatment for certain lipid metabolism disorders, aiming to correct genetic mutations or deficiencies in the APOC2 gene and restore normal protein function. However, this approach is still in the experimental stages and requires further research.

Are there any support groups or resources available for individuals and families affected by APOC2-related disorders? 10/25/2017

There are several support groups and resources available for individuals and families affected by lipid metabolism disorders, including those associated with APOC2 abnormalities. These organizations provide information, advocacy, and support to help individuals navigate their conditions. Examples include the National Lipid Association and the National Organization for Rare Disorders (NORD).

How is the APOC2 protein produced in the body? 09/12/2017

The APOC2 protein is synthesized in the liver and intestine.

Are there any known interactions or associations of APOC2 protein with other proteins or molecules? 06/11/2017

APOC2 protein interacts with various proteins and lipoproteins, including apolipoprotein C-III (APOC3) and apolipoprotein E (APOE), to regulate lipid metabolism and transport.

Can lifestyle modifications, such as diet and exercise, help manage APOC2-related disorders? 07/21/2016

Yes, lifestyle modifications, including a healthy diet and regular physical activity, play a crucial role in managing APOC2-related disorders. These interventions can help control lipid levels and improve overall cardiovascular health. However, they may not be sufficient as standalone treatments, and medical interventions may be necessary in some cases.

How prevalent are APOC2 gene mutations in the general population? 07/13/2016

APOC2 gene mutations are relatively rare in the general population. They are typically inherited in an autosomal recessive manner, meaning that individuals need to inherit mutated copies of the APOC2 gene from both parents to develop the associated disorders.

Customer Reviews (4)

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Reviews
07/03/2021

    The APOC2 protein offered by the manufacturer exhibits exceptional quality and is precisely tailored to meet my experimental requirements.

    03/21/2020

      Its purity, stability, and functionality make it an ideal choice for my research endeavors.

      04/25/2017

        In addition to the remarkable quality of the protein, the manufacturer's support extends beyond the provision of the product itself.

        11/13/2016

          With their meticulous documentation and support, I am confident that my utilization of APOC2 protein in clinical trials will meet all necessary regulations and guidelines.

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