| Cat. No.: | S100A12-3096H |
| Product Overview: | Recombinant Human S100A12 (N-terminal segment, Met 1-Glu 92), was expressed in E.coli. |
| Description: | S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S100 proteins have been implicated in a variety of intracellular and extracellular functions. They are involved in regulation of protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response. Protein S100-A12, also known as S100 calcium-binding protein A12, Calcium-binding protein in amniotic fluid 1, Calgranulin-C, and S100A12, is a member of the S-101 family. Like the majority of S100 proteins, S100A12 is a dimer, with the interface between the two subunits being composed mostly of hydrophobic residues. The fold of S100A12 is similar to the other known crystal and solution structures of S100 proteins, except for the linker region between the two EF-hand motifs. S100A12 plays an important role in the inflammatory response. |
| Source: | E.coli. |
| Purity: | > 98% as determined by SDS-PAGE. |
| Endotoxin: | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Predicted N Terminal: | Met 1. |
| Formulation: | Lyophilized from sterile PBS, pH 7.4. |
| Stability: | Samples are stable for up to twelve months from date of receipt at -70℃. |
| Storage: | Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Molecular Mass: | The recombinant human S100A12 consisting of 92 amino acids and has a calculated molecular mass of 10.6 kDa. It migrates as an 10 kDa band in SDS-PAGE under reducing conditions as predicted. |
| Gene Name: | S100A12 S100 calcium binding protein A12 [ Homo sapiens ] |
| Synonyms: | S100 calcium binding protein A12;p6; CAGC; CGRP; MRP6; CAAF1; ENRAGE; S100A12; protein S100-A12; EN-RAGE; calgranulin-C; neutrophil S100 protein; calcium-binding protein in amniotic fluid 1; S100 calcium-binding protein A12 (calgranulin C); extracellular newly identified RAGE-binding protein; Extracellular newly identified RAGE-binding protein; Calcium-binding protein in amniotic fluid 1; Neutrophil S100 protein; Calgranulin-C |
| Gene ID: | 6283 |
| mRNA Refseq: | NM_005621 |
| Protein Refseq: | NP_005612 |
| MIM: | 603112 |
| UniProt ID: | P80511 |
| Chromosome Location: | 1q21 |
| Function: | RAGE receptor binding; calcium ion binding; protein binding; zinc ion binding |
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