Native Human BGLAP protein
| Cat.No. : | BGLAP-60H |
| Product Overview : | Native Human BGLAP was purified from Human blood/plasma. |
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- Gene Information
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| Description : | This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. |
| Source : | Human blood/plasma |
| Species : | Human |
| Form : | 20 mM Tris, 150 mM NaCl, pH 7.4 |
| Molecular Mass : | 5,800 |
| Purity : | >95% by SDS-PAGE |
| Characteristic : | Single chain, one intrachain disulfide bond, Cys 23-29. Three gla residues, 17, 21, 24. Isoelectric Point: 4.0-4.5. |
| Notes : | Although the starting material was tested prior to initiation of the manufacturing process, and was found negative or nonreactive for anti-HIV-1/2, HIV-1 antigen(s), HBsAg, STS, antiHCV, anti-HBcore and anti-HTLV I & II, extreme caution should be used when handling this material as there is a margin of error in all tests. |
| Storage : | Store product at or below –80 centigrade. |
| Concentration : | 0.68 mg/ml |
| Gene Name : | BGLAP bone gamma-carboxyglutamate (gla) protein [ Homo sapiens ] |
| Official Symbol : | BGLAP |
| Synonyms : | BGLAP; bone gamma-carboxyglutamate (gla) protein; osteocalcin; bone Gla protein; gamma-carboxyglutamic acid-containing protein; bone gamma-carboxyglutamate (gla) protein (osteocalcin); OC; BGP; |
| Gene ID : | 632 |
| mRNA Refseq : | NM_199173 |
| Protein Refseq : | NP_954642 |
| MIM : | 112260 |
| UniProt ID : | P02818 |
| Chromosome Location : | 1q25-q31 |
| Pathway : | Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; DNA Replication, organism-specific biosystem; FGF signaling pathway, organism-specific biosystem; Glucocorticoid receptor regulatory network, organism-specific biosystem; M Phase, organism-specific biosystem; Mitotic M-M/G1 phases, organism-specific biosystem; |
| Function : | calcium ion binding; hydroxyapatite binding; structural constituent of bone; structural molecule activity; |
Products Types
| ◆ Recombinant Protein | ||
| BGLAP-364R | Recombinant Rhesus Macaque BGLAP Protein, His (Fc)-Avi-tagged | +Inquiry |
| Bglap-1143R | Recombinant Rat Bglap Protein, GST-tagged | +Inquiry |
| BGLAP-1263P | Recombinant Pig BGLAP Protein, His&GST-tagged | +Inquiry |
| BGLAP-2543H | Recombinant Human BGLAP Protein, His (Fc)-Avi-tagged | +Inquiry |
| Bglap-1262M | Recombinant Mouse Bglap Protein, His-tagged | +Inquiry |
| ◆ Native Protein | ||
| BGLAP-59B | Native Bovine Osteocalcin | +Inquiry |
| BGLAP-8519B | Native Bovine BGLAP | +Inquiry |
| BGLAP-57H | Native Human Osteocalcin | +Inquiry |
| ◆ Lysates | ||
| BGLAP-8460HCL | Recombinant Human BGLAP 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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