Native Bovine BGLAP BGLAP-8519B

Native Bovine BGLAP


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Native Bovine BGLAP

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Cat.No. : BGLAP-8519B Optional Service: Optional requirements on this protein
Product Overview : Native Bovine BGLAP is purified from Osteocalcin is prepared from bovine bone generally as described by Price et al. This involves demineralization in EDTA, size exclusion and ion exchange chromatography.
Description : Osteocalcin, also known as Bone-Gla-Protein (BGP), is a single chain (Mr=5800) vitamin K dependent protein produced by osteoblasts and found in high concentrations in bone. Post-translational modification by a vitamin K dependent carboxylase produces three g-carboxyglutamic acid residues at positions 17, 21 and 24. The mature protein contains 49 amino acids and a single intrachain disulfide bond joining Cys23 to Cys29. The secondary structure is highly calcium dependent and contains 14% α-helix, 20% β-sheet and 67% random form in the presence of calcium, and 1% α-helix, 20% β-sheet and 79% random form in the absence of calcium.
Source : Bovine
Species : Bovine
Form : 50% glycerol/H2O (v/v)
Molecular Mass : 5,800
Purity : >95% by SDS-PAGE
Storage : -80℃ aqueous; -20℃ glycerol
Gene Name : BGLAP bone gamma-carboxyglutamate (gla) protein [ Bos taurus ]
Official Symbol : BGLAP
Synonyms : BGLAP; BOS_2768; BGP; bone Gla protein; gamma-carboxyglutamic acid-containing protein; osteocalcin
Gene ID : 281646
mRNA Refseq : NM_174249.2
Protein Refseq : NP_776674.1
UniProt ID : P02820
Function : calcium ion binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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