Native Bovine Osteocalcin

• Cat.No.: BGLAP-286B

Specification

• Description: Osteocalcin, also known as Bone-Gla-Protein (BGP), is a single chain (Mr=5800) vitamin K dependent protein produced by osteoblasts and found in high concentrations in bone. Post-translational modification by a vitamin K dependent carboxylase produces three g-carboxyglutamic acid residues at positions 17, 21 and 24. The mature protein contains 49 amino acids and a single intrachain disulfide bond joining Cys23 to Cys29. The secondary structure is highly calcium dependent and contains 14% α-helix, 20% β-sheet and 67% random form in the presence of calcium, and 1% α-helix, 20% β-sheet and 79% random form in the absence of calcium.
• Source: Plasma
• Species: Bovine
• Form: 50% (vol/vol) glycerol/H2O
• Molecular Mass: 5800
• Characteristic: Extinction coefficient:13.3, Isoelectric point:4.0-4.5, Percent carbohydrate:0, Structure: Single chain, one intrachain disulfide bond, Cys 23-29.
• Storage: -20°C