Native Human Transferring

• Cat.No.: TF-5341H
• Product Overview: Native human TFexpressed by Human Plasma is a 76.5 kDa protein.

Specification

• Cat. No.: TF-5341H
• Description: Transferrin(TF) is a glycoprotein thought to have been created as a result of an ancient geneduplication event that led to generation of homologous C- and N-terminaldomainseachof which binds one ion of Ferric Iron. Therefore, each Human TF molecule hastheabilityto carry two Iron ions in the Ferric form (Fe3+). The function of TF is totransport Iron fromthe intestine, reticuloendothelial system, and liver parenchymal cells to all proliferatingcells in the body. TF may also have a physiologic role as Granulocyte/Pollen-BindingProtein (GPBP) involved in the removal of certain organic matterand allergens from serum. Apo-Transferrin designates the form of the molecule withoutIron bound. Like TF, APO-TF has a physiological role in the transportationanddistributionof Iron among the body organs. It is also an important transport factor used indefined culture media.
• Source: Human Plasma
• Species: Human
• Form: Lyophilized fromAmmonium Bicarbonate pH 7.2.
• Molecular Weight: 76.5 kDa
• Reconstitution: Centrifugevial prior to opening. Add deionized water to a concentration of10 mg/Ml, aliquotand freeze unused portion.
• Purity: > 95% by SDS-PAGE; Purifiedto have < 0.02 mgIron/g TF.
• Storage: Store at -70°C. 3years from delivery. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: TF
• Tag: Non

Gene Information

• Gene Name: TF transferrin [ Homo sapiens]
• Synonyms: TF; transferring; TFQTL1;PRO1557; PRO2086; DKFZp781D0156; serotransferrin; siderophilin; OTTHUMP00000197155;beta-1 metal-binding globulin
• Gene ID: 7018
• mRNA Refseq: NM_001063
• Protein Refseq: NP_001054
• MIM: 190000
• UniProt ID: P02787
• Chromosome Location: 3q22.1
• Pathway: EPHB forwardsignaling; HIF-1-alpha transcription factor network; Hemostasis; Iron uptakeand transport; Mineral absorption; Platelet activation; Plateletdegranulation; Response to elevated platelet cytosolic Ca2+; Transferrinendocytosis and recycling; Transmembrane transport of small molecules
• Function: ferric iron binding;metal ion binding; protein binding; ubiquitin protein ligase binding

Reviews

08/01/2020

Their team of experts is not only knowledgeable about the TF protein but is also dedicated to assisting researchers like myself in overcoming any challenges that may arise.

01/22/2018

This high-quality protein is crucial for the success of my experiments, ensuring that I obtain reliable and meaningful scientific findings.

04/11/2016

The TF protein is of exceptional quality, making it a perfect fit for my experimental needs.

Q&As

Can TF proteins be used for diagnosing diseases?

Yes, abnormalities in TF proteins can serve as diagnostic markers for certain diseases.

Are there any approved drugs that target TF proteins?

Yes, some drugs target TF proteins, especially in the treatment of cancer.

How do TF proteins contribute to autoimmune diseases?

TF proteins can trigger or suppress immune responses, making them relevant in understanding autoimmune diseases.

How do TF proteins play a crucial role in clinical applications?

TF proteins are vital for understanding disease mechanisms and can be targeted for therapeutic purposes.

Are there any clinical tests or assays that measure TF protein levels?

Yes, various assays, like ELISA and Western blot, can be used to quantify TF protein levels.