Recombinant Feline SAA1 Protein

• Cat.No.: SAA1-04H
• Product Overview: Recombinant feline serum amyloid A (SAA) consists of 112 amino acid residues (Contains an additional N-terminal methionine residue) without tag was expressed in E. coli. Theoretical pI is 5.50.

Specification

• Description: Major acute phase reactant. Apolipoprotein of the HDL complex.
• Source: E.coli
• Species: Feline
• Molecular Mass: 12.679 kDa
• Protein length: 112
• Purity: > 95% (Tricine-SDS-PAGE), affinity and ion-exchange chromatography.
• Applications: Can be used as a control in immunoassays.
• Stability: Avoid repeated freezing and thawing. It is recommended to aliquot the product after reconstitution.
• Storage: Lyophilized: -20 centigrade.
  Reconstituted: -70 centigrade.
• Storage Buffer: Lyophilized from 0.02 M Tris-HCl, pH 7.8, 0.15 M NaCl, 0.05% Tween 20
• Reconstitution: It is recommended to reconstitute this product with deionized water to its initial concentration. After reconstitution it is recommended to dilute feline SAA in a buffer containing a detergent compatible with the desired application.

Gene Information

• Gene Name: SAA1 serum amyloid A1 [ Felis catus (domestic cat) ]
• Official Symbol: SAA1
• Synonyms: SAA1; serum amyloid A1; SAA; serum amyloid A protein; serum amyloid A
• Gene ID: 678660
• mRNA Refseq: NM_001040198
• Protein Refseq: NP_001035288
• UniProt ID: Q1T772

Reviews

06/05/2022

Gel electrophoresis consistently displayed well-defined bands, affirming the product's purity and reliability.

09/21/2018

The product's manufacturer went above and beyond to ensure our satisfaction, strengthening our trust in the brand.

09/15/2018

The value derived from the product's usage made the investment worthwhile, considering the insights acquired.

Q&As

Are there specific stimuli or triggers that induce the expression and secretion of SAA1, influencing its role in the acute-phase response?

Specific stimuli or triggers, such as infection or tissue damage, induce the expression and secretion of SAA1, influencing its role in the acute-phase response.

What diseases or conditions are associated with dysregulation or abnormal expression of SAA1, especially in the context of inflammatory disorders?

Dysregulation or abnormal expression of SAA1 is associated with various inflammatory disorders, including rheumatoid arthritis and atherosclerosis.

In which cellular compartments is SAA1 predominantly synthesized and secreted?

SAA1 is predominantly synthesized in the liver and secreted into the bloodstream, serving as a major acute-phase protein.

What is the primary role of Serum Amyloid A1 (SAA1) in cellular processes and acute-phase responses?

Serum Amyloid A1 (SAA1) plays a crucial role in cellular processes, primarily contributing to acute-phase responses and inflammatory reactions.

How does SAA1 contribute to inflammation, particularly in the context of acute-phase reactions?

SAA1 contributes to inflammation by actively participating in acute-phase reactions, amplifying the immune response during various challenges.

Are there therapeutic implications or potential targets related to SAA1 in diseases involving acute-phase responses and chronic inflammation?

There are potential therapeutic implications related to SAA1 in diseases involving acute-phase responses and chronic inflammation, making it a target for drug development.

How does SAA1 participate in modulating immune responses and influencing the progression of inflammatory conditions?

SAA1 actively modulates immune responses, influencing the progression of inflammatory conditions and contributing to tissue repair.