SAA1

  • Official Full Name

    serum amyloid A1

  • Overview

    This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.
  • Synonyms

    SAA1; serum amyloid A1; SAA; serum amyloid A protein; PIG4; TP53I4; tumor protein p53 inducible protein 4; SAA2; MGC111216;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Transfected Stable Cell Lines
  • Bovine
  • Cat
  • Dog
  • Feline
  • Horse
  • Human
  • Monkey
  • Mouse
  • Rabbit
  • Rhesus
  • Rhesus Macaque
  • Sheep
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Mammalian Cell
  • Mammalian cells
  • Yeast
  • C
  • His
  • DEEP1
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|B2M
  • His|GST
  • His|SUMO|Myc
  • SUMO
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SAA1-2497H Recombinant Human SAA1, GST-tagged E.coli GST 23-122aa
Human Apo-SAA-3552H Recombinant Human Apo-SAA E.coli N/A 122
Human SAA1-31166TH Recombinant Human SAA1, His-tagged E.coli His
Human SAA1-31162TH Recombinant Human SAA1 N/A
Human Apo-SAA1-3553H Recombinant Human Apo-SAA1 E.coli N/A 122
Human SAA1-1403H Recombinant Human Serum Amyloid A1 E.coli N/A
Human SAA1-2668H Recombinant Human SAA1 protein E.coli N/A 104
Human SAA1-5110H Recombinant Human Serum Amyloid A1, His-tagged Human His
Human SAA1-2080HCL Recombinant Human SAA1 293 Cell Lysate HEK293 N/A
Human SAA1-2081HCL Recombinant Human SAA1 293 Cell Lysate HEK293 N/A
Human SAA1-3463H Recombinant Human SAA1 protein, His-tagged E.coli His 23-122 aa
Human SAA1-1052H Recombinant Human SAA Protein E.coli His
Human SAA1-1012H Recombinant Human SAA1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SAA1-3692H Recombinant Human SAA1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SAA1-73HFL Recombinant Full Length Human SAA1 Protein, C-Flag-tagged Mammalian cells Flag
Human SAA1-1947H Recombinant Human SAA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SAA1-6231H Recombinant Human SAA1 Protein (Ser20-Tyr122), N-His tagged E.coli N-His Ser20-Tyr122
Human SAA1-1947H-B Recombinant Human SAA1 Protein Pre-coupled Magnetic Beads HEK293
Human SAA1-6233H Recombinant Human SAA1 Protein (Arg19-Tyr122), N-His tagged E.coli N-His Arg19-Tyr122
Human SAA1-6232H Recombinant Human SAA1 Protein (Met1-Tyr122), C-His tagged Mammalian cells C-His Met1-Tyr122
Human SAA1-23H Active Human SAA Reference Standard N/A
Mouse Saa1-185M Active Recombinant Mouse Saa1 Protein E.coli N/A
Mouse Saa1-7876M Recombinant Mouse Saa1 protein, His-tagged E.coli His Gly20~Tyr122 (Accession# P05366)
Mouse SAA1-14633M Recombinant Mouse SAA1 Protein Mammalian Cell His
Mouse SAA1-71M Recombinant Mouse SAA1 Protein E.coli
Mouse Saa1-3468M Recombinant Mouse Saa1 protein, His-SUMO-tagged E.coli His-SUMO 20-122aa
Mouse SAA1-7876M-B Recombinant Mouse SAA1 Protein Pre-coupled Magnetic Beads HEK293
Monkey SAA1-4941M Recombinant Monkey Serum Amyloid A1 E.coli N/A
Rabbit SAA1-2375R Recombinant Rabbit SAA1 Protein (20-122 aa), His-SUMO-Myc-tagged E.coli His/SUMO/Myc 20-122 aa
Dog SAA1-1364D Recombinant Dog SAA1 Protein, His-GST-tagged E.coli His/GST
Bovine SAA1-4540B Recombinant Bovine SAA1 protein, His-tagged E.coli His 19-130aa
Bovine SAA1-3467B Recombinant Bovine SAA1 protein, His-SUMO & Myc-tagged E.coli His-SUMO & Myc 19-130aa
Cat SAA1-1363C Recombinant Cat SAA1 Protein, His-B2M-tagged E.coli His/B2M
Cat SAA1-1512C Recombinant Cat SAA1 Protein (1-90 aa), His-tagged Yeast His 1-90 aa
Feline SAA1-15F Recombinant Feline SAA1 Protein (1-111) E.coli 1-111
Feline SAA1-14F Recombinant Feline SAA1 Protein E.coli
Feline SAA1-04H Recombinant Feline SAA1 Protein E.coli 112
Horse SAA1-2345H Recombinant Horse SAA1 Protein (1-110 aa), His-tagged Yeast His 1-110 aa
Horse SAA1-795H Recombinant Horse SAA1 Protein (1-110 aa), His-tagged E.coli His 1-110 aa
Rhesus SAA1-5197R Recombinant Rhesus SAA1 protein E.coli N/A 104
Rhesus Macaque SAA1-001S Active Recombinant Rhesus Macaque SAA1 Protein (104 aa) E.coli 104
Sheep SAA1-1355S Recombinant Sheep SAA1 protein, His-tagged E.coli His 1-112aa
Sheep SAA1-4539S Recombinant Sheep SAA1 protein, DEEP1-tagged Yeast DEEP1 1-112aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

SAA1 involved in several pathways and played different roles in them. We selected most pathways SAA1 participated on our site, such as Activated TLR4 signalling, Advanced glycosylation endproduct receptor signaling, Amyloid formation, which may be useful for your reference. Also, other proteins which involved in the same pathway with SAA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activated TLR4 signallingAPPA;CHUK;DHX9;JUN;MAP3K8;ATF2;TANK;PELI3;CREB1B
Advanced glycosylation endproduct receptor signalingAPPA;S100A12;APPB;AGER;DDOST;S100B;ALCAMB;LGALS3;SAA1
Amyloid formationMFGE8;CALCA;HIST3H2BB;TTR;NAT8;TGFBI;CEACAM21;HIST2H3C;SEMG1
Binding and Uptake of Ligands by Scavenger ReceptorsIGKC;SPARC;APOBB.1;HP;LOC479668;CD163;COL1A2;COL3A1;HYOU1
Class A/1 (Rhodopsin-like receptors)GPR68;OPN1SW1;KEL;CHRM2;POMCB;SST1.1;PPY;GPR37L1;MLN
Cytosolic sensors of pathogen-associated DNALRRFIP1;NLRP4;POLR3F;TREX1;AGER;APPB;RIPK3;APPA;IFI16
DEx/H-box helicases activate type I IFN and inflammatory cytokines productionS100B;APPA;ALCAMB;AGER;CHST13;APPB;DHX9;S100A12;SAA1
Folate MetabolismABCA1;SAA2;SAA2-SAA4;SAA4;SAA1;AHCY

SAA1 has several biochemical functions, for example, G-protein coupled receptor binding, chemoattractant activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SAA1 itself. We selected most functions SAA1 had, and list some proteins which have the same functions with SAA1. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled receptor bindingNPB;RLN3;ITGB4;GNA15.4;GNAT2;GNA15;GNA13A;RSPO4;UCN2
chemoattractant activityCCL15;CXCL12B;NTF3;SAA1;CXCL12;SCG2;CCL5;FIGF;CCL16
heparin bindingCTGF;GPNMB;Itgam&Itgb2;LXN;C6orf25;APOH;NRP2;ECM2;SLIT3

SAA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SAA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SAA1.

d-mannose

Research Area

Related articles

Gouwy, M; De Buck, M; et al. Serum amyloid A chemoattracts immature dendritic cells and indirectly provokes monocyte chemotaxis by induction of cooperating CC and CXC chemokines. EUROPEAN JOURNAL OF IMMUNOLOGY 45:101-112(2015).
Matsui, S; Yamane, T; et al. Calcitonin Gene-Related Peptide Upregulates Serum Amyloid A Synthesis through Activation of Interleukin-6. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 77:2151-2153(2013).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
Are there specific stimuli or triggers that induce the expression and secretion of SAA1, influencing its role in the acute-phase response? 11/24/2021

Specific stimuli or triggers, such as infection or tissue damage, induce the expression and secretion of SAA1, influencing its role in the acute-phase response.

What diseases or conditions are associated with dysregulation or abnormal expression of SAA1, especially in the context of inflammatory disorders? 12/15/2020

Dysregulation or abnormal expression of SAA1 is associated with various inflammatory disorders, including rheumatoid arthritis and atherosclerosis.

In which cellular compartments is SAA1 predominantly synthesized and secreted? 10/05/2020

SAA1 is predominantly synthesized in the liver and secreted into the bloodstream, serving as a major acute-phase protein.

What is the primary role of Serum Amyloid A1 (SAA1) in cellular processes and acute-phase responses? 09/10/2017

Serum Amyloid A1 (SAA1) plays a crucial role in cellular processes, primarily contributing to acute-phase responses and inflammatory reactions.

How does SAA1 contribute to inflammation, particularly in the context of acute-phase reactions? 02/26/2017

SAA1 contributes to inflammation by actively participating in acute-phase reactions, amplifying the immune response during various challenges.

Are there therapeutic implications or potential targets related to SAA1 in diseases involving acute-phase responses and chronic inflammation? 01/21/2017

There are potential therapeutic implications related to SAA1 in diseases involving acute-phase responses and chronic inflammation, making it a target for drug development.

How does SAA1 participate in modulating immune responses and influencing the progression of inflammatory conditions? 03/05/2016

SAA1 actively modulates immune responses, influencing the progression of inflammatory conditions and contributing to tissue repair.

Customer Reviews (3)

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Reviews
06/05/2022

    Gel electrophoresis consistently displayed well-defined bands, affirming the product's purity and reliability.

    09/21/2018

      The product's manufacturer went above and beyond to ensure our satisfaction, strengthening our trust in the brand.

      09/15/2018

        The value derived from the product's usage made the investment worthwhile, considering the insights acquired.

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