SAA1
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Official Full Name
serum amyloid A1
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Overview
This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11. -
Synonyms
SAA1; serum amyloid A1; SAA; serum amyloid A protein; PIG4; TP53I4; tumor protein p53 inducible protein 4; SAA2; MGC111216;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Transfected Stable Cell Lines
- Bovine
- Cat
- Dog
- Feline
- Horse
- Human
- Monkey
- Mouse
- Rabbit
- Rhesus
- Rhesus Macaque
- Sheep
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Yeast
- Flag
- GST
- His
- B2M
- Fc
- Avi
- Myc
- SUMO
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
SAA1 involved in several pathways and played different roles in them. We selected most pathways SAA1 participated on our site, such as Activated TLR4 signalling, Advanced glycosylation endproduct receptor signaling, Amyloid formation, which may be useful for your reference. Also, other proteins which involved in the same pathway with SAA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activated TLR4 signalling | SIGIRR;PELI1;S100B;AGER;DUSP4;TANK;MAPK14;TLR6;DUSP3B |
| Advanced glycosylation endproduct receptor signaling | AGER;S100A12;APPB;SAA1;ALCAMB;APPA;LGALS3;DDOST;S100B |
| Amyloid formation | TGFBI;ODAM;NAT8B;APCS;HIST4H4;NAT8;HIST3H2BB;CST3;LTF |
| Binding and Uptake of Ligands by Scavenger Receptors | COL3A1;APOBB.1;SCGB3A2;HPX;SPARC;AMBP;HP;COL1A1;IGKC |
| Class A/1 (Rhodopsin-like receptors) | APLNR;PROK1;PENK;NMBB;ADRA2A;APLN;CCR3;AGTR2;DRD1 |
| Cytosolic sensors of pathogen-associated DNA | TREX1;LRRFIP1;POLR3C;DDX41;S100A12;NLRP4B;CHST13;ALCAMB;APPB |
| DEx/H-box helicases activate type I IFN and inflammatory cytokines production | DHX9;APPA;APPB;S100B;CHST13;SAA1;S100A12;ALCAMB;AGER |
| Folate Metabolism | SAA2;SAA4;ABCA1;SAA2-SAA4;AHCY;SAA1 |
SAA1 has several biochemical functions, for example, G-protein coupled receptor binding, chemoattractant activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SAA1 itself. We selected most functions SAA1 had, and list some proteins which have the same functions with SAA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor binding | ADORA1;GNA15.1;PICK1;SAA1;UCN2;GNAI2;SFTPB;PACRG;UCN3L |
| chemoattractant activity | FGF10;CCL16;VHL;NTF3;CCL5;VEGFA;CCL15;CXCL12B;SAA1 |
| heparin binding | NRP2;SERPIND1;ADAMTS3;LPL;CYR61L1;NRP1;PF4V1;WISP3;TENM1 |
SAA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SAA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SAA1.
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Customer Reviews (3)
Write a reviewGel electrophoresis consistently displayed well-defined bands, affirming the product's purity and reliability.
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Q&As (7)
Ask a questionSpecific stimuli or triggers, such as infection or tissue damage, induce the expression and secretion of SAA1, influencing its role in the acute-phase response.
Dysregulation or abnormal expression of SAA1 is associated with various inflammatory disorders, including rheumatoid arthritis and atherosclerosis.
SAA1 is predominantly synthesized in the liver and secreted into the bloodstream, serving as a major acute-phase protein.
Serum Amyloid A1 (SAA1) plays a crucial role in cellular processes, primarily contributing to acute-phase responses and inflammatory reactions.
SAA1 contributes to inflammation by actively participating in acute-phase reactions, amplifying the immune response during various challenges.
There are potential therapeutic implications related to SAA1 in diseases involving acute-phase responses and chronic inflammation, making it a target for drug development.
SAA1 actively modulates immune responses, influencing the progression of inflammatory conditions and contributing to tissue repair.
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