CCL20-327C
Optional Service: Optional requirements on this protein
Product Overview :
Recombinant Human MIP-3α/CCL20 produced in E. coliis a single non-glycosylated polypeptide chain containing 70 amino acids. A fully biologically active molecule, rhMIP-3α/CCL20has a molecular mass of 8.0 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
Description :
Chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family. It is strongly chemotactic for lymphocytes and weakly attracts neutrophils, also known as LARC (Liver and Activation-regulated Chemokine) and as Exodus. It can signal through the CCR6 receptor. MIP-3 alpha is chemotactic towards lymphocytes and dendritic cells. Additionally, it promotes the adhesion of memory CD4+ T cells and inhibits colony formation of bone marrow myeloid immature progenitors.
Source :
E. coli
Species :
Human
Form :
Sterile Filtered White lyophilized (freeze-dried) powder.
Bio-activity :
The EC50 value of humanMIP-3 alpha/CCL20 on Ca^2+ mobilization assay in CHO-K1/Gα15/hCCR6 cells (human Gα15 and human CCR6 stably expressed in CHO-K1 cells) is less than 200 ng/mL.
Lyophilized recombinant Human MIP- 3α/CCL20 remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, recombinant human MIP-3α/CCL20 should be stable up to 1 week at 4 centigrade or up to 2 months at -20 centigrade.
Storage Buffer :
Lyophilized after extensive dialysis against 53mM Na2HPO4, 147 mM NaH2PO4, 300 mM NaCl, pH6.5.
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.