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Recombinant Human F11 Protein, GST-tagged

Cat.No. : F11-3602H
Product Overview : Human F11 full-length ORF ( NP_000119.1, 1 a.a. - 625 a.a.) recombinant protein with GST-tag at N-terminal.
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Description : This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 96.5 kDa
AA Sequence : MIFLYQVVHFILFTSVSGECVTQLL KDTCFEGGDITTVFTPSAKYCQVVC TYHPRCLLFTFTAESPSEDPTRWFT CVLKDSVTETLPRVNRTAAISGYSF KQCSHQISACNKDIYVDLDMKGINY NSSVAKSAQECQERCTDDVHCHFFT YATRQFPSLEHRNICLLKHTQTGTP TRITKLDKVVSGFSLKSCALSNLAC IRDIFPNTVFADSNIDSVMAPDAFV CGRICTHHPGCLFFTFFSQEWPKES QRNLCLLKTSESGLPSTRIKKSKAL SGFSLQSCRHSIPVFCHSSFYHDTD FLGEELDIVAAKSHEACQKLCTNAV RCQFFTYTPAQASCNEGKGKCYLKL SSNGSPTKILHGRGGISGYTLRLCK MDNECTTKIKPRIVGGTASVRGEWP WQVTLHTTSPTQRHLCGGSIIGNQW ILTAAHCFYGVESPKILRVYSGILN QSEIKEDTSFFGVQEIIIHDQYKMA ESGYDIALLKLETTVNYTDSQRPIC LPSKGDRNVIYTDCWVTGWGYRKLR DKIQNTLQKAKIPLVTNEECQKRYR GHKITHKMICAGYREGGKDACKGDS GGPLSCKHNEVWHLVGITSWGEGCA QRERPGVYTNVVEYVDWILEKTQAV
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : F11 coagulation factor XI [ Homo sapiens ]
Official Symbol : F11
Synonyms : F11; coagulation factor XI; FXI; plasma thromboplastin antecedent; PTA; MGC141891;
Gene ID : 2160
mRNA Refseq : NM_000128
Protein Refseq : NP_000119
MIM : 264900
UniProt ID : P03951

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
11/12/2021

    The structure of the recombinant protein was analyzed by nuclear magnetic resonance (NMR), X-ray crystallography or electron microscopy, and the results showed that the protein was stable.

    05/24/2021

      In the process of purification, the removal of impurities is good.

      05/17/2021

        There are no structural or functional defects.

        Q&As (6)

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        Does F11 play a role in diabetes? 11/08/2022

        F11 plays an important role in diabetes, and abnormal levels may lead to insulin resistance and lipid metabolism disorders, which can lead to diabetes.

        What are the mutation types of F11? 04/15/2022

        The mutation types of F11 include point mutations, insertions/deletions, duplications, etc., which may cause structural and functional abnormalities of the protein.

        How to study the regulatory mechanism of F11? 10/27/2021

        Studying the regulatory mechanism of F11 requires the comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, protein interaction, etc.

        What disease might abnormal F11 levels suggest? 09/02/2021

        Abnormal F11 levels may indicate some diseases related to lipid metabolism, such as diabetes, obesity, hyperlipidemia, etc.

        How can the disease be treated by regulating F11 levels? 12/20/2020

        There are no drugs that directly regulate F11 levels, but they can be affected by lifestyle adjustments such as diet and exercise.

        What is the relationship between F11 and other genes or proteins? 08/05/2020

        F11 has a complex relationship with other genes or proteins, and can interact with other genes or proteins and participate in a variety of biochemical reactions.

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