Recombinant Human F11 Protein, GST-tagged

• Cat.No.: F11-3602H
• Product Overview: Human F11 full-length ORF ( NP_000119.1, 1 a.a. - 625 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 96.5 kDa
• AA Sequence: MIFLYQVVHFILFTSVSGECVTQLL KDTCFEGGDITTVFTPSAKYCQVVC TYHPRCLLFTFTAESPSEDPTRWFT CVLKDSVTETLPRVNRTAAISGYSF KQCSHQISACNKDIYVDLDMKGINY NSSVAKSAQECQERCTDDVHCHFFT YATRQFPSLEHRNICLLKHTQTGTP TRITKLDKVVSGFSLKSCALSNLAC IRDIFPNTVFADSNIDSVMAPDAFV CGRICTHHPGCLFFTFFSQEWPKES QRNLCLLKTSESGLPSTRIKKSKAL SGFSLQSCRHSIPVFCHSSFYHDTD FLGEELDIVAAKSHEACQKLCTNAV RCQFFTYTPAQASCNEGKGKCYLKL SSNGSPTKILHGRGGISGYTLRLCK MDNECTTKIKPRIVGGTASVRGEWP WQVTLHTTSPTQRHLCGGSIIGNQW ILTAAHCFYGVESPKILRVYSGILN QSEIKEDTSFFGVQEIIIHDQYKMA ESGYDIALLKLETTVNYTDSQRPIC LPSKGDRNVIYTDCWVTGWGYRKLR DKIQNTLQKAKIPLVTNEECQKRYR GHKITHKMICAGYREGGKDACKGDS GGPLSCKHNEVWHLVGITSWGEGCA QRERPGVYTNVVEYVDWILEKTQAV
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: F11 coagulation factor XI [ Homo sapiens ]
• Official Symbol: F11
• Synonyms: F11; coagulation factor XI; FXI; plasma thromboplastin antecedent; PTA; MGC141891
• Gene ID: 2160
• mRNA Refseq: NM_000128
• Protein Refseq: NP_000119
• MIM: 264900
• UniProt ID: P03951