Recombinant Human FLT3 protein, His & T7-tagged
Cat.No. : | FLT3-763H |
Product Overview : | Recombinant Human FLT3 aa. (Lys334~Ser543 (Accession # P36888)) fused with N-terminal His & T7 tag was produced in E. coli cells. |
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Description : | This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. |
Source : | E. coli |
Species : | Human |
Tag : | His&T7 |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 26.9kDa |
Protein length : | Lys334~Ser543 |
Endotoxin : | <1.0EU per 1µg (determined by the LAL method) |
Purity : | > 95% |
Characteristic : | The isoelectric point is 8.3. |
Applications : | SDS-PAGE; WB; ELISA; IP |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Storage buffer : | Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl |
Reconstitution : | Reconstitute in sterile PBS, pH7.2-pH7.4 |
Gene Name : | FLT3 fms related tyrosine kinase 3 [ Homo sapiens (human) ] |
Official Symbol : | FLT3 |
Synonyms : | FLT3; fms related tyrosine kinase 3; FLK2; STK1; CD135; FLK-2; receptor-type tyrosine-protein kinase FLT3; CD135 antigen; FL cytokine receptor; fetal liver kinase 2; fms-like tyrosine kinase 3; growth factor receptor tyrosine kinase type III; stem cell tyrosine kinase 1 |
Gene ID : | 2322 |
mRNA Refseq : | NM_004119.2 |
Protein Refseq : | NP_004110.2 |
UniProt ID : | P36888 |
Products Types
◆ Recombinant Protein | ||
FLT3-3434H | Recombinant Human FLT3 protein, His-tagged | +Inquiry |
FLT3-6334H | Recombinant Human FLT3 protein, His-tagged | +Inquiry |
FLT3-4371H | Recombinant Human FLT3 Protein, GST-tagged | +Inquiry |
FLT3-4370H | Active Recombinant Human FLT3 Protein, GST-tagged | +Inquiry |
FLT3-97P | Active Recombinant Porcine FLT-3 Ligand Protein | +Inquiry |
◆ Lysates | ||
FLT3-2561HCL | Recombinant Human FLT3 cell lysate | +Inquiry |
FLT3-970MCL | Recombinant Mouse FLT3 cell lysate | +Inquiry |
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewExcellent product, great price.
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Q&As (7)
Ask a questionFLT3 is frequently mutated in AML, contributing to uncontrolled cell growth and poor prognosis.
FLT3 is predominantly expressed in hematopoietic stem cells and progenitor cells.
It is essential for hematopoiesis, particularly in the proliferation of early progenitor cells.
Therapeutic strategies include FLT3 inhibitors, showing effectiveness in treating AML patients with FLT3 mutations.
FLT3 is a receptor tyrosine kinase that plays a crucial role in cell survival, proliferation, and differentiation.
It stimulates the proliferation and differentiation of hematopoietic stem cells, guiding their development into various blood cell types.
Common mutations include internal tandem duplications (ITD) and tyrosine kinase domain (TKD) mutations, leading to constitutive activation of FLT3.
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