Recombinant Human FLT3, GST-His
Cat.No. : | FLT3-688H |
Product Overview : | Recombinant human Flt-3 fused at the N-terminus to a GST-His6 thrombin cleavage site sequence was expressed inS. frugiperdainsect cells using a baculovirus expression system. MW = 82076 Da. |
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Cat. No. : | FLT3-688H |
Description : | Flt-3 belongs to the class III receptor tyrosine kinase family that is closely related to c-Kit and c-Fms. It is expressed in primitive hematopoietic cells and its ligand exerts proliferative effects on these cells in vitro in cooperation with other cytokines. Flt-3 is also expressed in the placenta, testis, spleen, thymus, bone marrow, brain and in cerebellar Purkinje cells. |
Source : | S. frugiperda. |
Form : | Liquid. In 100 mM NaCl, 50 mM Tris-HCl, 15 mM reduced glutathione, 5 mM DTT, 20% glycerol, pH 8.0. Please refer to vial label for lot-specific concentration. |
Unit Definition : | One unit is defined as the amount of enzyme required to transfer 1 nmol phosphate to Poly(Glu,Tyr)4:1 per min at 30°C, using variable concentrations of ATP (0.1-12.6 µM). |
Specific Activity : | ≥28 U/mg protein. |
Toxicity : | Standard Handling (MSDS available upon request). |
Storage : | ≤ -70°C. Avoid freeze/thaw Following initial thaw, aliquot and freeze (-70°C). |
Gene Name : | FLT3 fms-related tyrosine kinase 3 [ Homo sapiens ] |
Synonyms : | FLT3; fms-related tyrosine kinase 3; FLK2; STK1; CD135; CD135 antigen; fetal liver kinase 2; FL cytokine receptor; tal liver kinase 2; stem cell tyrosine kinase 1; FLT3 receptor tyrosine kinase; tyrosine-protein kinase receptor FLT3; growth factor receptor tyrosine kinase type III; C 2.7.10.1; OTTHUMP00000042340; fetal liver kinase 2 |
Gene ID : | 2322 |
mRNA Refseq : | NM_004119 |
Protein Refseq : | NP_004110 |
MIM : | 136351 |
UniProt ID : | P36888 |
Chromosome Location : | 13q12 |
Pathway : | ute myeloid leukemia; Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Pathways in cancer |
Function : | ATP binding; nucleotide binding; osphoinositide 3-kinase binding; protein binding; receptor activity; transferase activity; vascular endothelial growth factor receptor activity |
Products Types
◆ Recombinant Protein | ||
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FLT3-1507C | Recombinant Cynomolgus FLT3 protein, hFc-tagged | +Inquiry |
FLT3-1155R | Recombinant Rhesus Monkey FLT3 Protein, His-tagged | +Inquiry |
FLT3-4370H | Active Recombinant Human FLT3 Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
FLT3-2561HCL | Recombinant Human FLT3 cell lysate | +Inquiry |
FLT3-970MCL | Recombinant Mouse FLT3 cell lysate | +Inquiry |
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Not For Human Consumption!
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Q&As (7)
Ask a questionFLT3 is frequently mutated in AML, contributing to uncontrolled cell growth and poor prognosis.
FLT3 is predominantly expressed in hematopoietic stem cells and progenitor cells.
It is essential for hematopoiesis, particularly in the proliferation of early progenitor cells.
Therapeutic strategies include FLT3 inhibitors, showing effectiveness in treating AML patients with FLT3 mutations.
FLT3 is a receptor tyrosine kinase that plays a crucial role in cell survival, proliferation, and differentiation.
It stimulates the proliferation and differentiation of hematopoietic stem cells, guiding their development into various blood cell types.
Common mutations include internal tandem duplications (ITD) and tyrosine kinase domain (TKD) mutations, leading to constitutive activation of FLT3.
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