Recombinant Human IL17RA Protein, His-tagged
| Cat.No. : | IL17RA-312H |
| Product Overview : | Recombinant human IL17RA protein with His tag was expressed in HEK293. |
- Specification
- Gene Information
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| Description : | Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Source : | HEK293 |
| Species : | Human |
| Tag : | His |
| Form : | Lyophilized |
| Molecular Mass : | 34.3 kDa |
| Protein Length : | 866 |
| AA Sequence : | MGAARSPPSAVPGPLLGLLLLLLGV LAPGGASLRLLDHRALVCSQPGLNC TVKNSTCLDDSWIHPRNLTPSSPKD LQIQLHFAHTQQGDLFPVAHIEWTL QTDASILYLEGAELSVLQLNTNERL CVRFEFLSKLRHHHRRWRFTFSHFV VDPDQEYEVTVHHLPKPIPDGDPNH QSKNFLVPDCEHARMKVTTPCMSSG SLWDPNITVETLEAHQLRVSFTLWN ESTHYQILLTSFPHMENHSCFEHMH HIPAPRPEEFHQRSNVTLTLRNLKG CCRHQVQIQPFFSSCLNDCLRHSAT VSCPEMPDTPEPIPDYMPLWVYWFI TGISILLVGSVILLIVCMTWRLAGP GSEKYSDDTKYTDGLPAADLIPPPL KPRKVWIIYSADHPLYVDVVLKFAQ FLLTACGTEVALDLLEEQAISEAGV MTWVGRQKQEMVESNSKIIVLCSRG TRAKWQALLGRGAPVRLRCDHGKPV GDLFTAAMNMILPDFKRPACFGTYV VCYFSEVSCDGDVPDLFGAAPRYPL MDRFEEVYFRIQDLEMFQPGRMHRV GELSGDNYLRSPGGRQLRAALDRFR DWQVRCPDWFECENLYSADDQDAPS LDEEVFEEPLLPPGTGIVKRAPLVR EPGSQACLAIDPLVGEEGGAAVAKL EPHLQPRGQPAPQPLHTLVLAAEEG ALVAAVEPGPLADGAAVRLALAGEG EACPLLGSPGAGRNSVLFLPVDPED SPLGSSTPMASPDLLPEDVREHLEG LMLSLFEQSLSCQAQGGCSRPAMVL TDPHTPYEEEQRQSVQSDQGYISRS SPQPPEGLTEMEEEEEEEQDPGKPA LPLSPEDLESLRSLQRQLLFRQLQK NSGWDTMGSESEGPSA |
| Purity : | > 98% |
| Applications : | WB; ELISA; FACS; FC |
| Stability : | This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : | At -20 centigrade. |
| Concentration : | 1 mg/mL |
| Storage Buffer : | PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : | Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
| Gene Name : | IL17RA interleukin 17 receptor A [ Homo sapiens (human) ] |
| Official Symbol : | IL17RA |
| Synonyms : | IL17RA; interleukin 17 receptor A; IL17R, interleukin 17 receptor; interleukin-17 receptor A; CD217; CDw217; hIL 17R; IL 17RA; IL-17 receptor A; IL17R; CANDF5; IL-17RA; hIL-17R; FLJ32274; FLJ36453; MGC10262; |
| Gene ID : | 23765 |
| mRNA Refseq : | NM_014339 |
| Protein Refseq : | NP_055154 |
| MIM : | 605461 |
| UniProt ID : | Q96F46 |
Products Types
| ◆ Recombinant Protein | ||
| IL17RA-313H | Recombinant Human IL17RA Protein, Fc-tagged | +Inquiry |
| IL17RA-041H | Recombinant Human IL17RA Protein, His-tagged | +Inquiry |
| IL17RA-450H | Recombinant Human IL17RA Protein (Met1-Trp320), His-tagged, Biotinylated | +Inquiry |
| IL17RA-449H | Recombinant Human IL17RA Protein (Met1-Trp320), His-Fc-tagged, Biotinylated | +Inquiry |
| IL17RA-153H | Recombinant Active Human IL17RA Protein (ECD), His-tagged(C-ter) | +Inquiry |
| ◆ Lysates | ||
| IL17RA-2640HCL | Recombinant Human IL17RA cell lysate | +Inquiry |
| IL17RA-1070MCL | Recombinant Mouse IL17RA cell lysate | +Inquiry |
| IL17RA-1441RCL | Recombinant Rat IL17RA cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionSurface plasmon resonance, co-immunoprecipitation, and mutagenesis studies reveal IL17RA's binding partners and affinity.
Cross-pathway signaling assays, gene expression profiling, and functional rescue experiments unveil IL17RA's interaction networks.
Angiogenesis assays, fibroblast activation assays, and tissue remodeling models illuminate IL17RA's role in tissue repair.
Animal models, pharmacological interventions, and toxicity assessments evaluate IL17RA-targeted therapies and translational challenges.
Patient cohorts, clinical data analysis, and immune profiling provide insights into IL17RA's relevance in autoimmune diseases.
Flow cytometry, in vivo imaging, and chemotaxis assays characterize immune cell responses guided by IL17RA activation.
Phosphorylation assays, gene expression analysis, and knockout models dissect IL17RA-mediated signaling cascades.
Disease models, antibody-based treatments, and inflammatory biomarker assessments elucidate IL17RA's therapeutic potential.
ChIP-sequencing, promoter analysis, and epigenetic modification studies uncover IL17RA gene regulation mechanisms.
Epithelial barrier assays, microbiome analysis, and infection models decipher IL17RA's role in mucosal defense.
Customer Reviews (3)
Write a reviewEffective in T-cell activation. -
Suitable for co-immunoprecipitation. -
High solubility. -
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