Recombinant Human Interleukin 28B (interferon, lambda 3)

• Cat.No.: IL28B-600H
• Product Overview: Recombinant human IL28Bis expressed in human 293 cells with an apparent molecular mass of 24 kDa.This cytokine is produced in a serum-free, chemically defined media.Production in human 293 cells offers authentic human post-translationalmodification which contributes to stability in cell growth media and otherapplications. The purity is greater than 95%.

Specification

• Cat. No.: IL28B-600H
• Description: IL28 is a cytokinethat comes in two isoforms, IL28A and IL28B, and plays a role in immunedefense against viruses, including the induction an antiviral state byturning on Mx proteins, 2",5"-oligoadenylate synthetase as well as ISGF3G(Interferon Stimulated Gene Factor 3). IL28A and IL28B belong to the type IIIinterferon family of cytokines and are highly similar (in amino acidsequence) to IL-29.
• Source: HEK 293 cells
• Species: Human
• Purity: >95% The proteinwas resolved by SDS polyacrylamide gel electrophoresis and the gel was stainedwith Coomassie blue.
• Molecular Mass: 24 kDa monomer,non-glycosylated.
• Endotoxin Level: Endotoxin Free <1EU/μg
• Biological Activity: 0.1 to 1 ng/mL ED50
• Specific Activity: The specificactivity was determined by the dose dependent protection of the cytopathiceffect on A549 cells (human lung adenocarcinoma epithelial cell line) thatwere challenged with encephalomyocarditis (EMC) virus.
• OfficialSymbol: IL28B
• Pathways: Cytokine-cytokinereceptor interaction; Jak-STAT signaling pathway
• Tag: Non

Gene Information

• Gene Name: IL28B interleukin 28B(interferon, lambda 3) [ Homo sapiens ]
• Synonyms: IL28B;interleukin 28B (interferon, lambda 3); IFNL3; IL28C; IL-28B; interleukin-28B;IL-28C; IFN-lambda-3; IFN-lambda-4; interleukin 28C; interleukin-28C;cytokine Zcyto22; interferon lambda-3; interferon lambda-4; interferon,lambda 3; interferon, lambda 4; Interleukin-28B; Interferon lambda-4; Cytokine Zcyto22; Interferon lambda-3; Interleukin-28C
• Gene ID: 282617
• mRNA Refseq: NM_172139
• Protein Refseq: NP_742151
• MIM: 607402
• UniProt ID: Q8IZI9
• Chromosome Location: 19q13.13
• Function: cytokine activity

Reviews

07/24/2022

Activity retention time is very long and can be maintained for a long time.

02/04/2022

High cost performance and low preparation cost.

01/24/2022

It has a wide range of applications and can be used in various biological experiments.

Q&As

IL28B has made a breakthrough in treating what diseases?

IL28B has achieved remarkable results in the treatment of hepatitis C. The study found that patients with a specific genotype, which is related to IL28B, were better able to benefit from treatment with the hepatitis drug interferon. Therefore, the combination of IL28B with other drugs can improve the efficacy.

What is the mechanism of action of IL28B?

IL28B can regulate the immune response of cells and promote the occurrence of insulin-dependent cytotoxicity mediated by NK cells, thus playing an antiviral role.

IL28B purification ofs have?

The purification methods of IL28B include ion exchange, gel filtration, affinity chromatography, countercurrent chromatography, etc.

How many therapeutic doses of IL28B are usually used?

The dose of treatment with IL28B varies depending on the patient. When treating hepatitis C, the dose is usually given once a week, 500ug or another dose.

What are the adverse reactions of IL28B?

The adverse reactions of IL28B include fever, headache, fatigue, muscle aches, nausea, diarrhea and other symptoms, and in severe cases, allergic reactions and liver damage.

Does IL28B affect the function of other organs in the body?

IL28B will have a certain impact on the function of other organs of the body, such as the liver, kidneys, etc., but the use of normal doses in clinical practice is generally safe.