Recombinant Human Interleukin 28B (interferon, lambda 3)
|Product Overview :||Recombinant human IL28Bis expressed in human 293 cells with an apparent molecular mass of 24 kDa.This cytokine is produced in a serum-free, chemically defined media.Production in human 293 cells offers authentic human post-translationalmodification which contributes to stability in cell growth media and otherapplications. The purity is greater than 95%.|
- Gene Information
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|Cat. No. :||IL28B-600H|
|Description :||IL28 is a cytokinethat comes in two isoforms, IL28A and IL28B, and plays a role in immunedefense against viruses, including the induction an antiviral state byturning on Mx proteins, 2",5"-oligoadenylate synthetase as well as ISGF3G(Interferon Stimulated Gene Factor 3). IL28A and IL28B belong to the type IIIinterferon family of cytokines and are highly similar (in amino acidsequence) to IL-29.|
|Source :||HEK 293 cells|
|Purity :||>95% The proteinwas resolved by SDS polyacrylamide gel electrophoresis and the gel was stainedwith Coomassie blue.|
|Molecular Mass :||24 kDa monomer,non-glycosylated.|
|Endotoxin Level :||Endotoxin Free <1EU/μg|
|Biological Activity :||0.1 to 1 ng/mL ED50|
|Specific Activity :||The specificactivity was determined by the dose dependent protection of the cytopathiceffect on A549 cells (human lung adenocarcinoma epithelial cell line) thatwere challenged with encephalomyocarditis (EMC) virus.|
|Pathways :||Cytokine-cytokinereceptor interaction; Jak-STAT signaling pathway|
|Gene Name :||IL28B interleukin 28B(interferon, lambda 3) [ Homo sapiens ]|
|Synonyms :||IL28B;interleukin 28B (interferon, lambda 3); IFNL3; IL28C; IL-28B; interleukin-28B;IL-28C; IFN-lambda-3; IFN-lambda-4; interleukin 28C; interleukin-28C;cytokine Zcyto22; interferon lambda-3; interferon lambda-4; interferon,lambda 3; interferon, lambda 4; Interleukin-28B; Interferon lambda-4; Cytokine Zcyto22; Interferon lambda-3; Interleukin-28C|
|Gene ID :||282617|
|mRNA Refseq :||NM_172139|
|Protein Refseq :||NP_742151|
|UniProt ID :||Q8IZI9|
|Chromosome Location :||19q13.13|
|Function :||cytokine activity|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
IL28B has achieved remarkable results in the treatment of hepatitis C. The study found that patients with a specific genotype, which is related to IL28B, were better able to benefit from treatment with the hepatitis drug interferon. Therefore, the combination of IL28B with other drugs can improve the efficacy.
IL28B can regulate the immune response of cells and promote the occurrence of insulin-dependent cytotoxicity mediated by NK cells, thus playing an antiviral role.
The purification methods of IL28B include ion exchange, gel filtration, affinity chromatography, countercurrent chromatography, etc.
The dose of treatment with IL28B varies depending on the patient. When treating hepatitis C, the dose is usually given once a week, 500ug or another dose.
The adverse reactions of IL28B include fever, headache, fatigue, muscle aches, nausea, diarrhea and other symptoms, and in severe cases, allergic reactions and liver damage.
IL28B will have a certain impact on the function of other organs of the body, such as the liver, kidneys, etc., but the use of normal doses in clinical practice is generally safe.
Customer Reviews (3)Write a review
Activity retention time is very long and can be maintained for a long time. -
High cost performance and low preparation cost. -
It has a wide range of applications and can be used in various biological experiments. -
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