Recombinant Human LGALS3 Protein, His-tagged
Cat.No. : | LGALS3-408H |
Product Overview : | Recombinant Human LGALS3(Met1~Ile250) fused with His tag at N-terminal was expressed in E. coli. |
- Specification
- Gene Information
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Description : | This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
Molecular Mass : | 27.4kDa |
Identity : | Reconstitute in PBS or others |
Protein length : | Met1~Ile250 |
Endotoxin : | <1.0EU per 1µg (determined by the LAL method) |
Purity : | > 95% |
Applications : | Positive Control; Immunogen; SDS-PAGE; WB. If bio-activity of the protein is needed, please check active protein |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months. |
Reconstitution : | Reconstitute in PBS or others |
Gene Name : | LGALS3 lectin, galactoside-binding, soluble, 3 [ Homo sapiens ] |
Official Symbol : | LGALS3 |
Synonyms : | LGALS3; lectin, galactoside-binding, soluble, 3; LGALS2; galectin-3; galectin 3; GALIG; MAC 2; lectin L-29; 35 kDa lectin; MAC-2 antigen; IgE-binding protein; laminin-binding protein; galactose-specific lectin 3; carbohydrate-binding protein 35; L31; GAL3; MAC2; CBP35; GALBP; |
Gene ID : | 3958 |
mRNA Refseq : | NM_001177388 |
Protein Refseq : | NP_001170859 |
MIM : | 153619 |
UniProt ID : | P17931 |
Products Types
◆ Recombinant Protein | ||
LGALS3-2322R | Recombinant Rhesus Macaque LGALS3 Protein, His (Fc)-Avi-tagged | +Inquiry |
LGALS3-1290H | Recombinant Human LGALS3 Protein, His (Fc)-Avi-tagged | +Inquiry |
LGALS3-191H | Active Recombinant Human LGALS3 Protein (Ala2-Ile250), N-His tagged, Animal-free, Carrier-free | +Inquiry |
LGALS3-205H | Recombinant Human LGALS3 Protein | +Inquiry |
Lgals3-1311M | Recombinant Mouse Lgals3 Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
LGALS3-4766HCL | Recombinant Human LGALS3 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionLGALS3 has been investigated as a potential diagnostic and prognostic marker in various types of cancer. Its expression levels have been correlated with tumor stage, grade, and patient survival. LGALS3 can be detected in blood, urine, and tissue samples, making it a promising biomarker for non-invasive cancer detection and monitoring. Additionally, LGALS3 expression patterns, subcellular localization, and glycosylation status have been associated with specific cancer subtypes and clinical outcomes, providing insights into disease progression and patient prognosis.
The expression of LGALS3 is regulated at multiple levels, including transcriptional, post-transcriptional, and post-translational regulation. Transcription factors, such as Sp1, AP-1, and NF-κB, bind to the promoter region of the LGALS3 gene and regulate its expression. Epigenetic modifications, including DNA methylation and histone acetylation, can also influence LGALS3 expression. Additionally, microRNAs and RNA-binding proteins can regulate the stability and translation of LGALS3 mRNA. Moreover, various extracellular signals, such as cytokines and growth factors, can modulate LGALS3 expression in a tissue-specific and context-dependent manner.
LGALS3, also known as galectin-3, is a multifunctional protein involved in various cellular processes. It plays a role in cell adhesion, migration, apoptosis, immune response, and inflammation. LGALS3 can interact with glycosylated proteins and lipids, modulating their functions and signaling pathways. It also acts as a receptor for extracellular matrix proteins and plays a role in tissue remodeling. Additionally, LGALS3 has been implicated in cancer progression and metastasis, as well as in the regulation of fibrosis and wound healing.
Targeting LGALS3 has emerged as a potential therapeutic strategy in cancer treatment. Inhibition of LGALS3 expression or activity can impede tumor cell survival, migration, and invasion. Additionally, blocking LGALS3-mediated immune evasion mechanisms could enhance anti-tumor immune responses. Various approaches, such as small molecule inhibitors, antibodies, and gene silencing techniques, have been explored to target LGALS3 in preclinical and clinical studies. However, further research is needed to optimize these strategies and evaluate their efficacy and safety in cancer patients.
LGALS3 plays a critical role in immune response and inflammation. It can modulate the activation and function of immune cells, including macrophages, dendritic cells, and T cells. LGALS3 can promote cell adhesion and migration, facilitating immune cell recruitment to sites of inflammation. It also regulates the production of pro-inflammatory cytokines and chemokines, and can act as a chemoattractant for immune cells. Additionally, LGALS3 can modulate the clearance of apoptotic cells and regulate the resolution of inflammation.
LGALS3 contains a conserved carbohydrate recognition domain (CRD) that allows it to bind to glycosylated proteins and lipids. The CRD is responsible for LGALS3's interaction with specific glycan structures, mediating its diverse functions. LGALS3 also has a N-terminal domain involved in protein-protein interactions and a C-terminal domain that regulates its oligomerization. Moreover, LGALS3 can undergo post-translational modifications, such as phosphorylation and glycosylation, which can affect its localization, stability, and function.
LGALS3 has been implicated in various aspects of cancer progression and metastasis. It can promote tumor cell survival, migration, invasion, and angiogenesis. LGALS3 is involved in the modulation of epithelial-mesenchymal transition (EMT), a process essential for cancer cell metastasis. It also interacts with components of the extracellular matrix, promoting tumor cell adhesion and invasion. Furthermore, LGALS3 can influence immune evasion mechanisms employed by cancer cells, contributing to tumor immune escape and resistance to therapy.
Customer Reviews (3)
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The storage conditions for the reagent are simple and do not require special storage environments.
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