Recombinant Mouse Atp2b4 Protein, Myc/DDK-tagged

• Cat.No.: Atp2b4-1767M
• Product Overview: Purified recombinant protein of mouse full-length ATPase, Ca++ transporting, plasma membrane 4 (Atp2b4), transcript variant b, with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. By regulating sperm cell calcium homeostasis, may play a role in sperm motility.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 133.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Atp2b4 ATPase, Ca++ transporting, plasma membrane 4 [ Mus musculus (house mouse) ]
• Official Symbol: Atp2b4
• Synonyms: ATP2B4; ATPase, Ca++ transporting, plasma membrane 4; plasma membrane calcium ATPase 4; Pmca4; MGC129362; MGC129363
• Gene ID: 381290
• mRNA Refseq: NM_213616
• Protein Refseq: NP_998781
• UniProt ID: Q6Q477

Reviews

06/10/2021

Because it is not easy to be contaminated, it is stored again.

10/13/2020

The protein's activity is truly remarkable, able to catalyze reactions even under extreme conditions.

05/14/2020

ATP2B4's stability is truly remarkable, able to maintain its activity even under extreme conditions.

Q&As

Are mutations in ATP2B4 associated with rare genetic diseases?

ATP2B4 gene mutation may be related to some hereditary diseases such as acoustic neuroma and lung cancer.

What is the biological function of ATP2B4?

This is a calcium transporter, which is mainly responsible for transporting intracellular calcium to the outside of the cell, thereby maintaining the intracellular and extracellular calcium balance.

How does the protein structure and function of ATP2B4 differ from other atpase B family members?

There are several differences in protein structure and function between ATP2B4 and other atpase B family members, mainly depending on how they are expressed and regulated in different tissues and cells.

What are the pathways of ATP2B4 protein production?

The production pathway of ATP2B4 protein mainly includes multiple biological processes such as gene transcription, RNA splicing, protein translation and subsequent modification.

What diseases are associated with ATP2B4 expression?

The expression of ATP2B4 may be related to the occurrence and development of diabetes, obesity, cardiovascular disease, liver disease and other diseases.

Is ATP2B4 associated with cardiovascular disease?

The relationship between ATP2B4 and cardiovascular disease may be achieved through several mechanisms such as regulating cardiomyocyte contraction and vascular smooth muscle cell contraction.