Recombinant Mouse Interleukin 17C Carrier-Free, His-tagged

Cat.No. : Il17c-292M
Product Overview : Recombinant Mouse Carrier-Free protein IL-17C with His-tag was expressed inInsect cell.MW= 22.036 kDa.
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Cat. No. : Il17c-292M
Description : IL-17C is a member of the IL-17 family, which is comprised of six proteins (IL-17A through IL-17F). IL-17 proteins are pro-inflammatory cytokines that induce local cytokine production and are involved in the re-gulation of immune functions. IL-17C has been reported to stimulate the release of TNF-alpha and IL-1β from the monocytic cell line THP-1. IL-17C shares 15% to 30% amino acid sequence identity with the other IL-17 family members. Mouse and human IL-17C share 83% amino acid sequence identity. Mouse IL-17C cDNA encodes a 194 amino acid protein with a putative 14 amino acid signal peptide. The recombinant mouse IL-17C is a disulfide-linked homodimer composed of a 20.2 kDa monomeric subunit.
Source : Insect cell.
Handling Conditions : For best recovery, quick-spin vial prior to opening. Use in a sterile environment.
Purity : Greater than 97% as determined by SDS-PAGE.
Endotoxin Level : Less than 0.01 ng/ug cytokine as determined by the LAL assay.
Bioactivity : Testing in progress.
Formulation : 20 mM Phosphate, 0.2 M NaCl, pH 6.0, with 1.0% BSA.
Temperature Limitation : Store at less than or equal to –70°C.
Gene Name : Il17c interleukin 17C [ Mus musculus ]
Synonyms : interleukin 17C; IL-17C; MGC175740; Il17c
Gene ID : 234836
mRNA Refseq : NM_145834
Protein Refseq : NP_665833
Chromosome Location : 8 E1; 8
Function : cytokine activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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How is the involvement of IL17C in autoimmune diseases elucidated using experimental models and patient samples? 12/05/2022

Animal models, patient biopsies, and genetic association studies reveal IL17C's role in autoimmune diseases.

Can you explain the experimental designs used to study the crosstalk between IL17C and other cytokines in inflammatory responses? 06/30/2022

Combination cytokine stimulation assays and signaling pathway inhibitors elucidate IL17C's crosstalk.

How is the function of IL17C in promoting tumor growth and progression investigated in cancer models? 06/05/2022

Xenograft models and tumor growth measurements uncover IL17C's contribution to cancer progression.

How are the effects of IL17C modulation on specific immune cell populations characterized using flow cytometry and cell sorting? 01/18/2022

Flow cytometry analysis with cell-specific markers characterizes IL17C's impact on immune cell subsets.

What molecular techniques are utilized to validate the therapeutic potential of targeting IL17C in inflammatory disorders? 01/10/2022

Neutralizing antibodies and RNA interference validate IL17C's potential as a therapeutic target.

What approaches are taken to assess the role of IL17C in mucosal immunity and host defense against infections? 11/15/2021

Infection models, bacterial challenges, and mucosal sampling assess IL17C's role in host defense.

Could you elaborate on the methods used to study IL17C's contribution to tissue-specific immune cell recruitment? 04/29/2021

Chemotaxis assays and confocal microscopy study IL17C-mediated immune cell recruitment.

What strategies are used to explore the impact of IL17C on epithelial barrier integrity and inflammation? 10/26/2018

Organoid culture systems and cytokine measurements explore IL17C's impact on epithelial barrier function.

What experimental techniques are employed to investigate the binding partners of IL17C and its downstream signaling pathways? 12/21/2017

Co-immunoprecipitation and mass spectrometry identify IL17C interactors and signaling molecules.

How do researchers differentiate the functional roles of IL17C from other IL17 family members in immune responses? 04/10/2017

Comparative functional assays and gene knockout models distinguish IL17C's unique roles.

Customer Reviews (3)

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Reviews
11/26/2021

    High purity levels. -

    03/26/2021

      Potent in anti-fungal assays. -

      06/07/2020

        Suitable for receptor binding studies. -

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