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Recombinant Human IL17C protein, His-Avi-tagged

Cat.No. : IL17C-094H
Product Overview : Human IL-17C Protein is expressed from mammalian with His and Avi Tag at the C-terminal. It contains His19-Val197.
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Description : Interleukin‑17C (IL‑17C) is a 15‑20 kDa glycosylated cytokine that plays an important role in mucosal immunity and chronic inflammation. The six IL‑17 cytokines (IL‑17A‑F) are encoded by separate genes but adopt a conserved cystine knot fold. IL‑17C is Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G.
Source : HEK293
Species : Human
Tag : His-Avi
Form : Supplied as 0.22um filtered solution in PBS (pH 7.4).
Molecular Mass : The protein has a predicted MW of 22.6 kDa.
Protein length : His19-Val197
Endotoxin : Less than 1 EU per ug by the LAL method.
Storage : The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.
Gene Name : IL17C interleukin 17C [ Homo sapiens (human) ]
Official Symbol : IL17C
Synonyms : CX2; Cytokine CX2; IL17C; IL-17C; IL-17CMGC126884; interleukin 17C; interleukin-17C; MGC138401
Gene ID : 27189
mRNA Refseq : NM_013278.4
Protein Refseq : NP_037410.1
MIM : 604628
UniProt ID : Q9P0M4

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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How is the involvement of IL17C in autoimmune diseases elucidated using experimental models and patient samples? 12/05/2022

Animal models, patient biopsies, and genetic association studies reveal IL17C's role in autoimmune diseases.

Can you explain the experimental designs used to study the crosstalk between IL17C and other cytokines in inflammatory responses? 06/30/2022

Combination cytokine stimulation assays and signaling pathway inhibitors elucidate IL17C's crosstalk.

How is the function of IL17C in promoting tumor growth and progression investigated in cancer models? 06/05/2022

Xenograft models and tumor growth measurements uncover IL17C's contribution to cancer progression.

How are the effects of IL17C modulation on specific immune cell populations characterized using flow cytometry and cell sorting? 01/18/2022

Flow cytometry analysis with cell-specific markers characterizes IL17C's impact on immune cell subsets.

What molecular techniques are utilized to validate the therapeutic potential of targeting IL17C in inflammatory disorders? 01/10/2022

Neutralizing antibodies and RNA interference validate IL17C's potential as a therapeutic target.

What approaches are taken to assess the role of IL17C in mucosal immunity and host defense against infections? 11/15/2021

Infection models, bacterial challenges, and mucosal sampling assess IL17C's role in host defense.

Could you elaborate on the methods used to study IL17C's contribution to tissue-specific immune cell recruitment? 04/29/2021

Chemotaxis assays and confocal microscopy study IL17C-mediated immune cell recruitment.

What strategies are used to explore the impact of IL17C on epithelial barrier integrity and inflammation? 10/26/2018

Organoid culture systems and cytokine measurements explore IL17C's impact on epithelial barrier function.

What experimental techniques are employed to investigate the binding partners of IL17C and its downstream signaling pathways? 12/21/2017

Co-immunoprecipitation and mass spectrometry identify IL17C interactors and signaling molecules.

How do researchers differentiate the functional roles of IL17C from other IL17 family members in immune responses? 04/10/2017

Comparative functional assays and gene knockout models distinguish IL17C's unique roles.

Customer Reviews (3)

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Reviews
11/26/2021

    High purity levels.

    03/26/2021

      Potent in anti-fungal assays.

      06/07/2020

        Suitable for receptor binding studies.

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