Recombinant Mouse p28 Subunit (IL-27) Protein

Cat.No. : IL27-167M
Product Overview : Recombinant Mouse p28 Subunit (IL-27) Protein without tag was expressed in E. coli.
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  • Gene Information
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Description : The p28 subunit of interleukin 27 (IL-27), also known as interleukin 30 (IL-30), is a member of the interleukin 12 (IL-12) family of cytokines. p28 is a secreted polypeptide that associates with the Epstein-Barr virus induced gene 3 (EBI3) to form the IL-27 cytokine heterodimer complex. IL-27 functions as a proinflammatory cytokine that induces immunomodulatory effects in naïve CD4+ T cells, mast cells, and monocytes. p28 can also form a complex with cytokine-like factor 1 (CLF), that is secreted by dendritic cells, to regulate natural killer (NK) and T cell functions.
Source : E. coli
Species : Mouse
Bio-activity : No biological activity data is available at this time.
Molecular Mass : Monomer, 23.7 kDa (207 aa)
AA Sequence : MFPTDPLSLQELRREFTVSLYLARK LLSEVQGYVHSFAESRLPGVNLDLL PLGYHLPNVSLTFQAWHHLSDSERL CFLATTLRPFPAMLGGLGTQGTWTS SEREQLWAMRLDLRDLHRHLRFQVL AAGFKCSKEEEDKEEEEEEEEEEKK LPLGALGGPNQVSSQVSWPQLLYTY QLLHSLELVLSRAVRDLLLLSLPRR PGSAWDS
Endotoxin : ≤1 EUs/μg, Kinetic LAL
Purity : ≥95%, Reducing and Non-Reducing SDS PAGE
Stability : 12 months from date of receipt when stored at -20 to -80 centigrade as supplied.
1 month when stored at 4 centigrade after reconstituting as directed.
3 months when stored at -20 to -80 centigrade after reconstituting as directed.
Storage : Storage Prior to Reconstitution: -20 centigrade
Storage Buffer : Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium bicarbonate, pH 8.5
Reconstitution : Sterile water at 0.1 mg/mL
Shipping : Room temperature
Instructions : Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80 centigrade and avoid repeat freeze thaws.
Gene Name : Il27 interleukin 27 [ Mus musculus (house mouse) ]
Official Symbol : IL27
Synonyms : IL27; interleukin 27; interleukin-27 subunit alpha; IL27-A; IL-27-A; interleukin 30; IL-27 p28 subunit; IL-27 subunit alpha; p28; Il30; IL-27; IL-27p28;
Gene ID : 246779
mRNA Refseq : NM_145636
Protein Refseq : NP_663611
UniProt ID : Q8K3I6

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Are there have current difficulties in the study of Il27? 12/23/2022

The current challenges in the study of Il27 include potential side effects, preparation purity and other challenges.

Which scientific research fields are deeply studying Il27? 02/21/2022

The potential application of Il27 in tumor immunotherapy and autoimmune diseases is being deeply studied in the scientific research field.

Is the production of Il27 related to genetic factors? 09/19/2021

The production of Il27 is related to genetic factors, and the expression level and polymorphism of genes may affect its production and function.

Which role of Il27 in inflammatory diseases? 05/17/2021

Studies have shown that Il27 may have an anti-inflammatory effect in inflammatory diseases, regulating the degree of inflammatory response.

What the potential applications of recombinant Il27 in cancer therapy? 01/30/2021

Current studies have shown that Il27 has potential application value in enhancing anti-tumor immunity and alleviating tumor invasion and metastasis.

What is the effect of Il27 on immune response? 09/27/2020

Il27 can enhance the activation and proliferation of specific immune cells and regulate the intensity and direction of immune response.

Customer Reviews (3)

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Reviews
03/30/2022

    The regulation effect of IL-27 on specific gene expression was detected by Western blot or Real-time PCR. -

    08/05/2020

      IL-27 is a complex cytokine whose function and regulatory mechanisms are still under investigation. -

      05/30/2019

        Immunohistochemistry, immunofluorescence and other techniques can be used to detect the expression and localization of IL-27 in tissues to further understand its function and regulatory mechanism. -

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