Recombinant Mouse p28 Subunit (IL-27) Protein
|Product Overview :||Recombinant Mouse p28 Subunit (IL-27) Protein without tag was expressed in E. coli.|
- Gene Information
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|Description :||The p28 subunit of interleukin 27 (IL-27), also known as interleukin 30 (IL-30), is a member of the interleukin 12 (IL-12) family of cytokines. p28 is a secreted polypeptide that associates with the Epstein-Barr virus induced gene 3 (EBI3) to form the IL-27 cytokine heterodimer complex. IL-27 functions as a proinflammatory cytokine that induces immunomodulatory effects in naïve CD4+ T cells, mast cells, and monocytes. p28 can also form a complex with cytokine-like factor 1 (CLF), that is secreted by dendritic cells, to regulate natural killer (NK) and T cell functions.|
|Source :||E. coli|
|Bio-activity :||No biological activity data is available at this time.|
|Molecular Mass :||Monomer, 23.7 kDa (207 aa)|
|AA Sequence :||MFPTDPLSLQELRREFTVSLYLARK LLSEVQGYVHSFAESRLPGVNLDLL PLGYHLPNVSLTFQAWHHLSDSERL CFLATTLRPFPAMLGGLGTQGTWTS SEREQLWAMRLDLRDLHRHLRFQVL AAGFKCSKEEEDKEEEEEEEEEEKK LPLGALGGPNQVSSQVSWPQLLYTY QLLHSLELVLSRAVRDLLLLSLPRR PGSAWDS|
|Endotoxin :||≤1 EUs/μg, Kinetic LAL|
|Purity :||≥95%, Reducing and Non-Reducing SDS PAGE|
|Stability :||12 months from date of receipt when stored at -20 to -80 centigrade as supplied.
1 month when stored at 4 centigrade after reconstituting as directed.
3 months when stored at -20 to -80 centigrade after reconstituting as directed.
|Storage :||Storage Prior to Reconstitution: -20 centigrade|
|Storage Buffer :||Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium bicarbonate, pH 8.5|
|Reconstitution :||Sterile water at 0.1 mg/mL|
|Shipping :||Room temperature|
|Instructions :||Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80 centigrade and avoid repeat freeze thaws.|
|Gene Name :||Il27 interleukin 27 [ Mus musculus (house mouse) ]|
|Official Symbol :||IL27|
|Synonyms :||IL27; interleukin 27; interleukin-27 subunit alpha; IL27-A; IL-27-A; interleukin 30; IL-27 p28 subunit; IL-27 subunit alpha; p28; Il30; IL-27; IL-27p28;|
|Gene ID :||246779|
|mRNA Refseq :||NM_145636|
|Protein Refseq :||NP_663611|
|UniProt ID :||Q8K3I6|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
The current challenges in the study of Il27 include potential side effects, preparation purity and other challenges.
The potential application of Il27 in tumor immunotherapy and autoimmune diseases is being deeply studied in the scientific research field.
The production of Il27 is related to genetic factors, and the expression level and polymorphism of genes may affect its production and function.
Studies have shown that Il27 may have an anti-inflammatory effect in inflammatory diseases, regulating the degree of inflammatory response.
Current studies have shown that Il27 has potential application value in enhancing anti-tumor immunity and alleviating tumor invasion and metastasis.
Il27 can enhance the activation and proliferation of specific immune cells and regulate the intensity and direction of immune response.
Customer Reviews (3)Write a review
The regulation effect of IL-27 on specific gene expression was detected by Western blot or Real-time PCR. -
IL-27 is a complex cytokine whose function and regulatory mechanisms are still under investigation. -
Immunohistochemistry, immunofluorescence and other techniques can be used to detect the expression and localization of IL-27 in tissues to further understand its function and regulatory mechanism. -
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