Active Recombinant Human IL27, HIgG1 Fc-tagged, mutant
|Product Overview :||The human IL-27 complex composed of the Ebi3 subunit(NP_005746.2) (Arg21-Lys229) and the p28 subunit(NP_663634.2)(Val26-Pro243) is fused through a polypeptide linker to the Fc region of a mutant human IgG1was expressed in CHO cell|
- Gene Information
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|Description :||The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein isrelated to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similarto interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but notmemory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferongamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by theclass I cytokine receptor (WSX1/TCRR).|
|Source :||CHO cells|
|Tag :||HIgG1 Fc-tagged, mutant|
|Form :||Lyophilized from 0.2μm-filtered solution in PBS.|
|Bio-activity :||Bioactivity was measured in a cell proliferation assay using anti-CD3 activated human peripheral mononuclear cells.|
|Molecular Mass :||78 KDa (monomer)|
|AA Sequence :||Arg21-Lys229|
|Endotoxin :||<0.06 eu/μg as determined by lal>0.06>|
|Purity :||>98%, by SDS-PAGE under reducing conditions.|
|Stability :||Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.|
|Reconstitution :||Reconstitute at 100μg/ml in sterile PBS.|
|Warning :||Avoid freeze/thaw cycles.|
|Gene Name :||IL27 interleukin 27 [ Homo sapiens ]|
|Official Symbol :||IL27|
|Synonyms :||IL27; interleukin 27;|
|Gene ID :||144841|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
The current challenges in the study of Il27 include potential side effects, preparation purity and other challenges.
The potential application of Il27 in tumor immunotherapy and autoimmune diseases is being deeply studied in the scientific research field.
The production of Il27 is related to genetic factors, and the expression level and polymorphism of genes may affect its production and function.
Studies have shown that Il27 may have an anti-inflammatory effect in inflammatory diseases, regulating the degree of inflammatory response.
Current studies have shown that Il27 has potential application value in enhancing anti-tumor immunity and alleviating tumor invasion and metastasis.
Il27 can enhance the activation and proliferation of specific immune cells and regulate the intensity and direction of immune response.
Customer Reviews (3)Write a review
The purity is very high, no impurities. -
Biological activity is very strong and can be used in various biological experiments. -
Stability is very good, and it will not denaturate at high temperatures. -
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