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ACVR2A

  • Official Full Name

    activin receptor IIA

  • Overview

    Activin receptor type-2A is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor. This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
  • Synonyms

    ACTRII; ACVR2; activin receptor IIA; ACVR2A;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Xenopus laevis (African clawed frog)
  • CHO
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • C
  • His
  • hFc
  • Fc
  • Fc|His
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • mFc
  • Myc
  • DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ACVR2A-3819H Active Recombinant Human ACVR2A, His tagged HEK293 His Met 1-Pro 134
Human ACVR2A-8314H Active Recombinant Human ACVR2A Sf21 Insect Cell N/A
Human ACVR2A-532H Active Recombinant Human ACVR2A, Fc-tagged, Biotinylated Human Cell Fc
Human ACVR2A-254H Active Recombinant Human ACVR2A Protein, GST-tagged Insect Cell GST
Human ACVR2A-195H Active Recombinant Human ACVR2A protein, hFc-tagged HEK293 hFc Met1-Pro134
Human ACVR2A-P015H Recombinant Human ActRIIA therapeutic protein, Fc-tagged Fc
Human ACVR2A-26487TH Recombinant Human ACVR2A Wheat Germ N/A 513 amino acids
Human ACVR2A-255H Recombinant Human ACVR2A Protein, GST-tagged Wheat Germ GST
Human ACVR2A-1585H Recombinant Human Activin A Receptor, Type IIA Sf21 Insect Cell N/A
Human ACVR2A-883H Recombinant Human ACVR2A Protein, His-tagged HEK293 His
Human ACVR2A-884H Recombinant Human ACVR2A Protein, Fc/His-tagged HEK293 Fc/His
Human ACVR2A-6994H Recombinant Human ACVR2A, His-tagged Sf9 Insect Cell His 161 aa-end
Human ACVR2A-3096HCL Recombinant Human ACVR2A cell lysate Human Cell N/A
Human ACVR2A-07HF Recombinant Full Length Human ACVR2A Protein In Vitro Cell Free System 513 amino acids
Human ACVR2A-083H Recombinant Human ACVR2A Protein, Fc-tagged HEK293 Fc 513
Human ACVR2A-292H Recombinant Human ACVR2A Protein, His/GST-tagged E.coli His/GST Ala20~Pro135
Human ACVR2A-01H Recombinant Active Human ACVR2A Protein, His-tagged Insect Cell His
Human ACVR2A-831HF Recombinant Full Length Human ACVR2A Protein, GST-tagged In Vitro Cell Free System GST 513 amino acids
Human ACVR2A-2889H Active Recombinant Human ACVR2A protein, Fc-tagged HEK293 Fc Ala 20-Pro 135
Human ACVR2A-3097HCL Recombinant Human ACVR2A cell lysate, Myc/DDK tag HEK293T Myc/DDK
Human ACVR2A-0320H Recombinant Human ACVR2A Protein (Ala20-Pro1354), C-His-tagged Mammalian cells C-His Ala20-Pro1354
Human ACVR2A-0322H Recombinant Human ACVR2A Protein (Ala20-Pro135), N-GST-tagged E.coli N-GST Ala20-Pro135
Human ACVR2A-510H Recombinant Human ACVR2A Protein, GST-tag Insect Cell GST
Human ACVR2A-0319H Recombinant Human ACVR2A Protein (Ala20-Pro134 ), C-His-tagged Mammalian cells C-His Ala20-Pro134
Human ACVR2A-0785H Recombinant Human ACVR2A Protein (P191-N487), Tag Free Insect Cell No tag P191-N487
Human ACVR2A-14H Recombinant Human ACVR2A Protein, Fc tagged CHO Fc
Human ACVR2A-0786H Recombinant Human ACVR2A Protein (P191-N487), His tagged Insect Cell His P191-N487
Mouse Acvr2a-493M Active Recombinant Mouse Acvr2a protein(Met1-Pro134), His&hFc-tagged HEK293 C-His&hFc Met1-Pro134
Mouse Acvr2a-492M Recombinant Mouse Acvr2a, His tagged Human Cell His
Mouse ACVR2A-2280MCL Recombinant Mouse ACVR2A cell lysate Human Cell N/A
Mouse Acvr2a-01M Active Recombinant Mouse Acvr2a Protein, mFc tagged HEK293 mFc
Mouse Acvr2a-293M Recombinant Mouse Acvr2a Protein, His-tagged E.coli His Ala20~Lys95
Rat ACVR2A-494R Recombinant Rat ACVR2A Protein Mammalian Cell His
Rat ACVR2A-150R Recombinant Rat ACVR2A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ACVR2A-150R-B Recombinant Rat ACVR2A Protein Pre-coupled Magnetic Beads HEK293
Bovine ACVR2A-290B Recombinant Bovine ACVR2A Protein, His-tagged E.coli His Leu192~Ser325
Homo sapiens (Human) RFL-13669HF Recombinant Full Length Human Activin Receptor Type-2A(Acvr2A) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (20-513)
Mus musculus (Mouse) RFL-4199MF Recombinant Full Length Mouse Activin Receptor Type-2A(Acvr2A) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (20-513)
Rattus norvegicus (Rat) RFL-32518RF Recombinant Full Length Rat Activin Receptor Type-2A(Acvr2A) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (20-513)
Xenopus laevis (African clawed frog) RFL-8325XF Recombinant Full Length Xenopus Laevis Activin Receptor Type-2A(Acvr2A) Protein, His-Tagged E.coli expression system His Full Length (21-514)
Chicken ACVR2A-6919C Recombinant Chicken ACVR2A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ACVR2A Related Research Area

ACVR2A involved in several pathways and played different roles in them. We selected most pathways ACVR2A participated on our site, such as Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACVR2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionFLT4;IFNA4;IL12BA;CCR6;IL28A;TNFSF15;CXCL6;IFNGR2;IL4
TGF-beta signaling pathwayINHBC;BMP2B;TGFB2;EP300;ACVR1C;SPAW;BMPR2;RHOAD;TFDP1
Signaling pathways regulating pluripotency of stem cellsINHBC;PIK3CD;PCGF6;SOX2;WNT2B;ACVR1;NRAS;ACVR2A;PCGF5

ACVR2A has several biochemical functions, for example, ATP binding, PDZ domain binding, contributes_to activin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACVR2A itself. We selected most functions ACVR2A had, and list some proteins which have the same functions with ACVR2A. You can find most of the proteins on our site.

Function Related Protein
ATP bindingDHX32A;CKMB;ADCY6;TBCK;ASS1;MYH13;DNAHC8;P2RX2;SHPK
PDZ domain bindingLPAR2;PDZK1;PTENA;SNTA1;FZD2;CRIPT;PROSAPIP1;PTEN;ATP2B1
contributes_to activin bindingACVR1B;ACVR2A
contributes_to activin-activated receptor activityACVR1B;ACVR2A
coreceptor activityCD80;ZP2;CCR5;PVRL2;CXCR7;LRP5;RAMP1;ACKR3B;CD86
growth factor bindingNKD2;LIFR;ERBB3;ACVR2B;LTBP2;TEK;HTRA1B;RPL37;A2M
inhibin bindingINHBA;ACVR1B;INHA;ACVR2A;IGSF1
metal ion bindingZNF671;ZNHIT2;TRIM7;ZNF750;ZFP93;TGFBR1;PPM1AA;ENTPD7;ATP13A1
protein bindingMYPOP;SCIMP;PITX2;CDC42BPG;RAB27B;ZC3H15;CDKN2D;DYSFIP1;POLR2C
contributes_to protein bindingMLH1;MEF2A;TGFBR3;ACVR2A;MSH2;INHA;MSH6;POLR2A;PAK1
protein self-associationNKX3;RSAD2;CCL5;BCL10;S100A7A;AGTR1B;NKX3-1;TMEM190;RYR2
protein serine/threonine kinase activityIKBKB;MAPK8A;PAK2;PRKCBB;TSSK6;SMOK3B;MAP4K1;PRKAA2;HIPK3
receptor signaling protein serine/threonine kinase activityACVR2B;TGFB2;ACVR1C;BMPR1AB;ACVR1L;TGFBR1A;STK24A;ACVR1;TGFBR2
transmembrane receptor protein serine/threonine kinase activityBMPR2A;BMPR1B;BMPR1BB;BMPR1AB;ACVR2AA;TGFBR1A;BMPR1A;BMPR1AA;BMPR2B

ACVR2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACVR2A here. Most of them are supplied by our site. Hope this information will be useful for your research of ACVR2A.

Magi2; DAXX; linkable pd173955 analogue

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