C5 Protein, complement component 5


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Official Full Name complement component 5
Background The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis. [provided by RefSeq, Jul 2008]
Synonyms C5; complement component 5; C5D; C5a; C5b; ECLZB; CPAMD4; complement C5; prepro-C5; C5a anaphylatoxin; anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4;
    • Species :
    • Cynomolgus
    • Human
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Human Plasma
    • Human Serum
    • Mouse
    • Wheat Germ
    • Tag :
    • Biotin
    • GST
    • His
    • Flag
    • human
    • IgG1
    • Fc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human C5-092H Recombinant Human C5 protein, Fc-tagged HEK293 human/IgG1/Fc
    Cynomolgus C5-452C Recombinant Cynomolgus C5 protein E.coli
    Rat C5-511R Recombinant Rat C5 protein, His-tagged HEK293 His
    Human C5-536H Recombinant Human C5 protein, His-tagged HEK293 His
    Human C5-575H Recombinant Human C5 Protein (Gln19-Cys1676), His-FLAG-tagged HEK293 His/Flag
    Cynomolgus C5-681C Recombinant Cynomolgus C5 protein, His-tagged HEK293 His
    Human C5-851H Recombinant Human C5 protein (W917S), His-tagged HEK293 His
    Human C5-9288H Recombinant Human C5 protein (R885H), His-tagged HEK293 His
    Human C5-0077H Recombinant Human C5 Protein, GST-Tagged Wheat Germ GST
    Human C5-10539H Recombinant Human C5, His-tagged E.coli His
    Human C5-10540H Native Human C5 Human Serum N/A
    Human C5-26131TH Recombinant Human C5, His-tagged E.coli His
    Human C5-4756H Recombinant Human C5 E.coli N/A
    Human C5-53H Native Human Complement C5 Human Plasma N/A
    Human C5-562H Recombinant Human C5 Protein, GST-tagged E.coli GST
    Human C5-8020HCL Recombinant Human C5 293 Cell Lysate HEK293 N/A
    Human CAB11483MH Mouse Anti-Human Complement Component 5 Monoclonal Antibody Mouse N/A
    Human DMABT-H19242 Mouse Anti-C5 Monoclonal Antibody Mouse N/A
    Human DMABT-H19243 Mouse Anti-C5 Monoclonal Antibody Mouse Biotin
    Rat C5-564R Recombinant Rat C5 Protein, His/GST-tagged E.coli His/GST
    Rat C5-565R Recombinant Rat C5 Protein, His/GST-tagged E.coli His/GST

    C5 involved in several pathways and played different roles in them. We selected most pathways C5 participated on our site, such as Complement and coagulation cascades, Prion diseases, Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with C5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Complement and coagulation cascades PLAU; F7; TFPI; C8G; C5; C1QC; CFI; GM5077; PROS1; FGB
    Prion diseases C7; MAPK3; MAP2K2; PRKACA; C5; STIP1; PRKACG; C8G; PRKACB; C1QB
    Pertussis CALM4; CASP7; C1RA; FOS; LY96; ITGA5; NOS2; C5; CXCL6; CALML3
    Staphylococcus aureus infection FPR3; C5; C1QC; FCGR3B; HLA-DRB1; FCAR; C1R; PTAFR; C5AR1; HLA-DRA
    Herpes simplex infection Casp3; TLR9; POLR2A; IFNA2; C3A.1; PPP1CC; TAF6; Hc; SRSF7A; ALYREF
    Systemic lupus erythematosus HIST1H3D; GM14478; ELANE; H2-AA; C8A; HIST2H3C1; C5; HIST1H4L; H2-AB1; HIST1H3G

    C5 has several biochemical functions, for example, chemokine activity, endopeptidase inhibitor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by C5 itself. We selected most functions C5 had, and list some proteins which have the same functions with C5. You can find most of the proteins on our site.

    Function Related Protein
    chemokine activity CCL34A.4; CXCL2; CXCL1; CXCL20; CCL20B; CCL25B; CCL20A.3; Ccl9; PPBP; CCL34A.3
    endopeptidase inhibitor activity CST3; SPINK2; C3; CST14B.1; CAST; STFA1; C3A.2; SERPINA1E; PROS1; TFPI
    protein binding NINJ2; CLNK; RPS11; UGGT1; CT45A3; MAGI1; COMMD8; EDARADD; PLEC; SNAI2
    receptor binding RIPK2; APOF; DIAPH1; LAMA2; NCR3; CD276; PVRL1A; KCNA5; Ifnl2; FGF12B

    C5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C5 here. Most of them are supplied by our site. Hope this information will be useful for your research of C5.

    CREB3L1; vco3_najka; d3jib2_staau

    Hallstensen, RF; Bergseth, G; et al. Eculizumab treatment during pregnancy does not affect the complement system activity of the newborn. IMMUNOBIOLOGY 220:452-459(2015).
    Ohta, T; Urayama, K; et al. Eculizumab in the treatment of atypical hemolytic uremic syndrome in an infant leads to cessation of peritoneal dialysis and improvement of severe hypertension. PEDIATRIC NEPHROLOGY 30:603-608(2015).

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