|Official Full Name||complement component 5|
|Background||The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis. [provided by RefSeq, Jul 2008]|
|Synonyms||C5; complement component 5; C5D; C5a; C5b; ECLZB; CPAMD4; complement C5; prepro-C5; C5a anaphylatoxin; anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
C5 involved in several pathways and played different roles in them. We selected most pathways C5 participated on our site, such as Complement and coagulation cascades, Prion diseases, Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with C5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Complement and coagulation cascades||PLAU; F7; TFPI; C8G; C5; C1QC; CFI; GM5077; PROS1; FGB|
|Prion diseases||C7; MAPK3; MAP2K2; PRKACA; C5; STIP1; PRKACG; C8G; PRKACB; C1QB|
|Pertussis||CALM4; CASP7; C1RA; FOS; LY96; ITGA5; NOS2; C5; CXCL6; CALML3|
|Staphylococcus aureus infection||FPR3; C5; C1QC; FCGR3B; HLA-DRB1; FCAR; C1R; PTAFR; C5AR1; HLA-DRA|
|Herpes simplex infection||Casp3; TLR9; POLR2A; IFNA2; C3A.1; PPP1CC; TAF6; Hc; SRSF7A; ALYREF|
|Systemic lupus erythematosus||HIST1H3D; GM14478; ELANE; H2-AA; C8A; HIST2H3C1; C5; HIST1H4L; H2-AB1; HIST1H3G|
C5 has several biochemical functions, for example, chemokine activity, endopeptidase inhibitor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by C5 itself. We selected most functions C5 had, and list some proteins which have the same functions with C5. You can find most of the proteins on our site.
|chemokine activity||CCL34A.4; CXCL2; CXCL1; CXCL20; CCL20B; CCL25B; CCL20A.3; Ccl9; PPBP; CCL34A.3|
|endopeptidase inhibitor activity||CST3; SPINK2; C3; CST14B.1; CAST; STFA1; C3A.2; SERPINA1E; PROS1; TFPI|
|protein binding||NINJ2; CLNK; RPS11; UGGT1; CT45A3; MAGI1; COMMD8; EDARADD; PLEC; SNAI2|
|receptor binding||RIPK2; APOF; DIAPH1; LAMA2; NCR3; CD276; PVRL1A; KCNA5; Ifnl2; FGF12B|
C5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C5 here. Most of them are supplied by our site. Hope this information will be useful for your research of C5.
CREB3L1; vco3_najka; d3jib2_staau