Recombinant Human C5 Protein, GST-tagged
Cat.No. : | C5-562H |
Product Overview : | Recombinant Human C5(Thr678~Arg751) fused with GST tag at N-terminal was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants. |
Source : | E. coli |
Species : | Human |
Tag : | GST |
Form : | 20mM Tris, 150mM NaCl,pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300. |
Molecular Mass : | 34.4kDa |
Identity : | Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex. |
Protein length : | Thr678~Arg751 |
Endotoxin : | <1.0EU per 1µg (determined by the LAL method) |
Purity : | > 95% |
Applications : | Positive Control; Immunogen; SDS-PAGE; WB. If bio-activity of the protein is needed, please check active protein |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months. |
Reconstitution : | Reconstitute in PBS or others |
Gene Name : | C5 complement component 5 [ Homo sapiens ] |
Official Symbol : | C5 |
Synonyms : | C5; complement component 5; complement C5; CPAMD4; anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4; FLJ17816; FLJ17822; MGC142298; |
Gene ID : | 727 |
mRNA Refseq : | NM_001735 |
Protein Refseq : | NP_001726 |
MIM : | 120900 |
UniProt ID : | P01031 |
Products Types
◆ Recombinant Protein | ||
C5-344H | Recombinant Human C5 Protein, His-tagged | +Inquiry |
C5-0077H | Recombinant Human C5 Protein, GST-Tagged | +Inquiry |
C5-348P | Recombinant Pig C5 Protein, His-tagged | +Inquiry |
C5-0053H | Recombinant Human C5 Protein (G981-Q1306), His tagged | +Inquiry |
C5-575H | Recombinant Human C5 Protein (Gln19-Cys1676), His-FLAG-tagged | +Inquiry |
◆ Native Protein | ||
C5-53H | Native Human Complement C5 | +Inquiry |
C5-10540H | Active Native Human C5 | +Inquiry |
◆ Lysates | ||
C5-8020HCL | Recombinant Human C5 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, C5 inhibition has shown promise in treating multiple sclerosis by modulating the inflammatory response and reducing damage to the central nervous system.
C5 can be targeted using monoclonal antibodies, such as eculizumab, which inhibits its activity. This approach has been successful in managing various complement-related disorders.
In PNH, a mutation leads to uncontrolled complement activation, resulting in the destruction of red blood cells. Inhibiting C5 can prevent this process and improve clinical outcomes.
C5 inhibition can increase susceptibility to certain infections. Close monitoring and appropriate preventive measures are essential to manage the infection risk in patients receiving C5-targeted therapies.
In rheumatoid arthritis, C5 contributes to inflammation and joint damage. Targeting C5 in treatment may help mitigate the inflammatory response.
Customer Reviews (3)
Write a reviewWhether I am studying protein interactions, cellular localization, or signaling pathways, the C5 protein consistently delivers reliable and reproducible data, enabling significant scientific advancements.
Its superior purity and stability ensure reliable and accurate results, instilling confidence in my research.
Their assistance has been invaluable in streamlining my experiments and overcoming obstacles effectively.
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