Active Recombinant Human C5 protein

Cat.No. : C5-4756H
Product Overview : Recombinant Human C5 protein(NP_001726.2)(Leu679-Arg751) was expressed in E. coli.
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Source : E. coli
Species : Human
Tag : N/A
Form : Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Bio-activity : Measured by its ability to induce N-acetyl-β-D-glucosaminidase release from differentiated U937 human histiocytic lymphoma cells. The ED50 for this effect is typically 5-15 ng/mL.
Molecular Mass : The recombinant human C5a consists of 74 amino acids and has a predicted molecular mass of 8.3 kDa which is also estimated by SDS-PAGE.
Proteinlength : Leu679-Arg751
Purity : > 94 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.
Storage : Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : C5 complement component 5 [ Homo sapiens ]
Official Symbol : C5
Synonyms : C5; complement component 5; complement C5; CPAMD4; anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4; FLJ17816; FLJ17822; MGC142298;
Gene ID : 727
mRNA Refseq : NM_001735
Protein Refseq : NP_001726
MIM : 120900
UniProt ID : P01031

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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can C5 inhibition be a potential therapy for neuroinflammatory conditions such as multiple sclerosis? 01/10/2023

Yes, C5 inhibition has shown promise in treating multiple sclerosis by modulating the inflammatory response and reducing damage to the central nervous system.

How is the C5 protein targeted in therapeutic interventions, and what are the available modalities? 08/25/2022

C5 can be targeted using monoclonal antibodies, such as eculizumab, which inhibits its activity. This approach has been successful in managing various complement-related disorders.

How is the C5 protein involved in the pathogenesis of diseases like PNH? 02/21/2019

In PNH, a mutation leads to uncontrolled complement activation, resulting in the destruction of red blood cells. Inhibiting C5 can prevent this process and improve clinical outcomes.

How does C5 inhibition impact the risk of infections in patients undergoing treatment? 11/16/2016

C5 inhibition can increase susceptibility to certain infections. Close monitoring and appropriate preventive measures are essential to manage the infection risk in patients receiving C5-targeted therapies.

What role does C5 play in the progression of inflammatory diseases like rheumatoid arthritis? 09/01/2016

In rheumatoid arthritis, C5 contributes to inflammation and joint damage. Targeting C5 in treatment may help mitigate the inflammatory response.

Customer Reviews (3)

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Reviews
09/29/2019

    Whether I am studying protein interactions, cellular localization, or signaling pathways, the C5 protein consistently delivers reliable and reproducible data, enabling significant scientific advancements.

    10/23/2018

      Its superior purity and stability ensure reliable and accurate results, instilling confidence in my research.

      11/20/2016

        Their assistance has been invaluable in streamlining my experiments and overcoming obstacles effectively.

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